Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/228606 |
Resumo: | Topical antimicrobials are the ideal mode of onychomycosis treatment for efficient drug delivery and avoidance of sytemic effects associated with oral medications. However, high treatment costs, tissue penetration limitations, and low cure rates have continued to pose major challenges. To capitalize on the progress made by topical efinaconazole solution, efinaconazole was combined with inexpensive, previously-characterized nitric oxide releasing nanoparticles (NO-np), which have been shown to offer sustained nitric oxide release over time and enhanced barrier penetration, while exerting broad spectrum antimicrobial and immunomodulating properties. NO-np were combined with efinaconazole in varying concentrations and applied against reference strains of Trichophyton rubrum using a checkerboard method. Results demonstrated synergism of NO-np+efinaconazole against T. rubrum, which is noteworthy given the barriers present in the topical treatment of onychomycosis, and the multiple potential benefits offered by NO-np. Overall, this study illustrates the untapped potential of nanotechnology in the treatment of disorders of the skin, hair, and nails where drug delivery remains a challenge. |
id |
UNSP_45f1b1880ad5e6413f171154517d58fa |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/228606 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatmentsTopical antimicrobials are the ideal mode of onychomycosis treatment for efficient drug delivery and avoidance of sytemic effects associated with oral medications. However, high treatment costs, tissue penetration limitations, and low cure rates have continued to pose major challenges. To capitalize on the progress made by topical efinaconazole solution, efinaconazole was combined with inexpensive, previously-characterized nitric oxide releasing nanoparticles (NO-np), which have been shown to offer sustained nitric oxide release over time and enhanced barrier penetration, while exerting broad spectrum antimicrobial and immunomodulating properties. NO-np were combined with efinaconazole in varying concentrations and applied against reference strains of Trichophyton rubrum using a checkerboard method. Results demonstrated synergism of NO-np+efinaconazole against T. rubrum, which is noteworthy given the barriers present in the topical treatment of onychomycosis, and the multiple potential benefits offered by NO-np. Overall, this study illustrates the untapped potential of nanotechnology in the treatment of disorders of the skin, hair, and nails where drug delivery remains a challenge.Department of Clinical Analysis Universidade Estadual Paulista Faculdade de Ciências FarmacêuticasDepartment of Medicine Division of Infectious Diseases Albert Einstein College of MedicineDepartment of Medicine Division of Dermatology Albert Einstein College of MedicineDepartment of Physiology and Biophysics Albert Einstein College of MedicineDepartment of Dermatology George Washington School of Medicine and Health SciencesDepartment of Clinical Analysis Universidade Estadual Paulista Faculdade de Ciências FarmacêuticasUniversidade Estadual Paulista (UNESP)Albert Einstein College of MedicineGeorge Washington School of Medicine and Health SciencesCosta-Orlandi, Caroline B. [UNESP]Mordorski, BreanneBaltazar, Ludmila M.Mendes-Giannini, Maria José S. [UNESP]Friedman, Joel M.Nosanchuk, Joshua D.Friedman, Adam J.2022-04-29T08:27:45Z2022-04-29T08:27:45Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article717-720Journal of Drugs in Dermatology, v. 17, n. 7, p. 717-720, 2018.1545-9616http://hdl.handle.net/11449/2286062-s2.0-85055616350Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Drugs in Dermatologyinfo:eu-repo/semantics/openAccess2024-06-21T15:18:56Zoai:repositorio.unesp.br:11449/228606Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-06-21T15:18:56Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments |
title |
Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments |
spellingShingle |
Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments Costa-Orlandi, Caroline B. [UNESP] |
title_short |
Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments |
title_full |
Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments |
title_fullStr |
Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments |
title_full_unstemmed |
Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments |
title_sort |
Nitric oxide releasing nanoparticles as a strategy to improve current onychomycosis treatments |
author |
Costa-Orlandi, Caroline B. [UNESP] |
author_facet |
Costa-Orlandi, Caroline B. [UNESP] Mordorski, Breanne Baltazar, Ludmila M. Mendes-Giannini, Maria José S. [UNESP] Friedman, Joel M. Nosanchuk, Joshua D. Friedman, Adam J. |
author_role |
author |
author2 |
Mordorski, Breanne Baltazar, Ludmila M. Mendes-Giannini, Maria José S. [UNESP] Friedman, Joel M. Nosanchuk, Joshua D. Friedman, Adam J. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Albert Einstein College of Medicine George Washington School of Medicine and Health Sciences |
dc.contributor.author.fl_str_mv |
Costa-Orlandi, Caroline B. [UNESP] Mordorski, Breanne Baltazar, Ludmila M. Mendes-Giannini, Maria José S. [UNESP] Friedman, Joel M. Nosanchuk, Joshua D. Friedman, Adam J. |
description |
Topical antimicrobials are the ideal mode of onychomycosis treatment for efficient drug delivery and avoidance of sytemic effects associated with oral medications. However, high treatment costs, tissue penetration limitations, and low cure rates have continued to pose major challenges. To capitalize on the progress made by topical efinaconazole solution, efinaconazole was combined with inexpensive, previously-characterized nitric oxide releasing nanoparticles (NO-np), which have been shown to offer sustained nitric oxide release over time and enhanced barrier penetration, while exerting broad spectrum antimicrobial and immunomodulating properties. NO-np were combined with efinaconazole in varying concentrations and applied against reference strains of Trichophyton rubrum using a checkerboard method. Results demonstrated synergism of NO-np+efinaconazole against T. rubrum, which is noteworthy given the barriers present in the topical treatment of onychomycosis, and the multiple potential benefits offered by NO-np. Overall, this study illustrates the untapped potential of nanotechnology in the treatment of disorders of the skin, hair, and nails where drug delivery remains a challenge. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 2022-04-29T08:27:45Z 2022-04-29T08:27:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Journal of Drugs in Dermatology, v. 17, n. 7, p. 717-720, 2018. 1545-9616 http://hdl.handle.net/11449/228606 2-s2.0-85055616350 |
identifier_str_mv |
Journal of Drugs in Dermatology, v. 17, n. 7, p. 717-720, 2018. 1545-9616 2-s2.0-85055616350 |
url |
http://hdl.handle.net/11449/228606 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Drugs in Dermatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
717-720 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803649771010785280 |