Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs

Detalhes bibliográficos
Autor(a) principal: Diniz, Miriely S. [UNESP]
Data de Publicação: 2018
Outros Autores: Teixeira-Neto, Francisco J. [UNESP], Goncalves, Daniele S. [UNESP], Celeita-Rodriguez, Nathalia [UNESP], Girotto, Carolina H. [UNESP], Fonseca, Mariana W. [UNESP], Takahira, Regina K. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1111/jvim.15327
http://hdl.handle.net/11449/186291
Resumo: Background Objective Tetrastarch solution (TS) can impair coagulation but the clinical relevance of this impairment is unclear in veterinary medicine. Compare the effects of volume replacement (VR) with lactated Ringer's solution (LRS) or 6% TS on coagulation in hemorrhaged dogs. Animals Methods Six healthy English Pointer dogs (19.7-35.3 kg). Prospective crossover study. Dogs were anesthetized without hemorrhage and VR (control). Two weeks later, dogs were hemorrhaged under anesthesia on 2 occasions (8-week washout intervals) and randomly received VR with LRS or TS at 3:1 or 1:1 of shed blood, respectively, aiming to decrease the hematocrit to 33%. Rotational thromboelastometry and other coagulation variables were determined before 0.5, 2, and 4 hours after VR during anesthesia and 24 hours after VR (conscious dogs). Results Conclusions and Clinical Relevance Buccal mucosal bleeding time did not differ between treatments after VR. Activated partial thromboplastin time increased from controls 4 hours after TS (P = 0.045). Clot formation time (CFT) and alfa-angle increased from controls from 0.5 to 4 hours after LRS (CFT, P <= 0.0001-0.02; alpha angle, P = 0.0001-0.02) and from 0.5 to 2 hours after TS (CFT, P = 0.0002-0.01; alpha angle, P = 0.0005-0.02). The maximum clot firmness decreased from controls from 0.5 to 4 hours after LRS (P <= 0.0001-0.01) and TS (P <= 0.0001-0.04). Tetrastarch does not impair primary hemostasis and induces transient dilutional coagulopathy that is similar to LRS because, when compared to a 3 times higher volume of LRS in hemorrhaged dogs, it does not cause greater interference on the viscoelastic properties of the coagulum.
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spelling Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogscoagulationcolloidscrystalloidshydroxyethyl starchthromboelastometryBackground Objective Tetrastarch solution (TS) can impair coagulation but the clinical relevance of this impairment is unclear in veterinary medicine. Compare the effects of volume replacement (VR) with lactated Ringer's solution (LRS) or 6% TS on coagulation in hemorrhaged dogs. Animals Methods Six healthy English Pointer dogs (19.7-35.3 kg). Prospective crossover study. Dogs were anesthetized without hemorrhage and VR (control). Two weeks later, dogs were hemorrhaged under anesthesia on 2 occasions (8-week washout intervals) and randomly received VR with LRS or TS at 3:1 or 1:1 of shed blood, respectively, aiming to decrease the hematocrit to 33%. Rotational thromboelastometry and other coagulation variables were determined before 0.5, 2, and 4 hours after VR during anesthesia and 24 hours after VR (conscious dogs). Results Conclusions and Clinical Relevance Buccal mucosal bleeding time did not differ between treatments after VR. Activated partial thromboplastin time increased from controls 4 hours after TS (P = 0.045). Clot formation time (CFT) and alfa-angle increased from controls from 0.5 to 4 hours after LRS (CFT, P <= 0.0001-0.02; alpha angle, P = 0.0001-0.02) and from 0.5 to 2 hours after TS (CFT, P = 0.0002-0.01; alpha angle, P = 0.0005-0.02). The maximum clot firmness decreased from controls from 0.5 to 4 hours after LRS (P <= 0.0001-0.01) and TS (P <= 0.0001-0.04). Tetrastarch does not impair primary hemostasis and induces transient dilutional coagulopathy that is similar to LRS because, when compared to a 3 times higher volume of LRS in hemorrhaged dogs, it does not cause greater interference on the viscoelastic properties of the coagulum.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual PaulistaUniv Estadual Paulista, Fac Med, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med, Botucatu, SP, BrazilUniv Estadual Paulista, Fac Med Vet & Zootecnia, BR-18618970 Botucatu, SP, BrazilCNPq: 306342/2015-4FAPESP: 2014/25115-8FAPESP: 2015/04810-2Wiley-BlackwellUniversidade Estadual Paulista (Unesp)Diniz, Miriely S. [UNESP]Teixeira-Neto, Francisco J. [UNESP]Goncalves, Daniele S. [UNESP]Celeita-Rodriguez, Nathalia [UNESP]Girotto, Carolina H. [UNESP]Fonseca, Mariana W. [UNESP]Takahira, Regina K. [UNESP]2019-10-04T18:33:47Z2019-10-04T18:33:47Z2018-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1927-1933http://dx.doi.org/10.1111/jvim.15327Journal Of Veterinary Internal Medicine. Hoboken: Wiley, v. 32, n. 6, p. 1927-1933, 2018.1939-1676http://hdl.handle.net/11449/18629110.1111/jvim.15327WOS:000451827600015Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Veterinary Internal Medicineinfo:eu-repo/semantics/openAccess2021-10-23T14:26:50Zoai:repositorio.unesp.br:11449/186291Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:00:47.528959Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs
title Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs
spellingShingle Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs
Diniz, Miriely S. [UNESP]
coagulation
colloids
crystalloids
hydroxyethyl starch
thromboelastometry
title_short Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs
title_full Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs
title_fullStr Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs
title_full_unstemmed Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs
title_sort Effects of 6% tetrastarch or lactated Ringer's solution on blood coagulation in hemorrhaged dogs
author Diniz, Miriely S. [UNESP]
author_facet Diniz, Miriely S. [UNESP]
Teixeira-Neto, Francisco J. [UNESP]
Goncalves, Daniele S. [UNESP]
Celeita-Rodriguez, Nathalia [UNESP]
Girotto, Carolina H. [UNESP]
Fonseca, Mariana W. [UNESP]
Takahira, Regina K. [UNESP]
author_role author
author2 Teixeira-Neto, Francisco J. [UNESP]
Goncalves, Daniele S. [UNESP]
Celeita-Rodriguez, Nathalia [UNESP]
Girotto, Carolina H. [UNESP]
Fonseca, Mariana W. [UNESP]
Takahira, Regina K. [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Diniz, Miriely S. [UNESP]
Teixeira-Neto, Francisco J. [UNESP]
Goncalves, Daniele S. [UNESP]
Celeita-Rodriguez, Nathalia [UNESP]
Girotto, Carolina H. [UNESP]
Fonseca, Mariana W. [UNESP]
Takahira, Regina K. [UNESP]
dc.subject.por.fl_str_mv coagulation
colloids
crystalloids
hydroxyethyl starch
thromboelastometry
topic coagulation
colloids
crystalloids
hydroxyethyl starch
thromboelastometry
description Background Objective Tetrastarch solution (TS) can impair coagulation but the clinical relevance of this impairment is unclear in veterinary medicine. Compare the effects of volume replacement (VR) with lactated Ringer's solution (LRS) or 6% TS on coagulation in hemorrhaged dogs. Animals Methods Six healthy English Pointer dogs (19.7-35.3 kg). Prospective crossover study. Dogs were anesthetized without hemorrhage and VR (control). Two weeks later, dogs were hemorrhaged under anesthesia on 2 occasions (8-week washout intervals) and randomly received VR with LRS or TS at 3:1 or 1:1 of shed blood, respectively, aiming to decrease the hematocrit to 33%. Rotational thromboelastometry and other coagulation variables were determined before 0.5, 2, and 4 hours after VR during anesthesia and 24 hours after VR (conscious dogs). Results Conclusions and Clinical Relevance Buccal mucosal bleeding time did not differ between treatments after VR. Activated partial thromboplastin time increased from controls 4 hours after TS (P = 0.045). Clot formation time (CFT) and alfa-angle increased from controls from 0.5 to 4 hours after LRS (CFT, P <= 0.0001-0.02; alpha angle, P = 0.0001-0.02) and from 0.5 to 2 hours after TS (CFT, P = 0.0002-0.01; alpha angle, P = 0.0005-0.02). The maximum clot firmness decreased from controls from 0.5 to 4 hours after LRS (P <= 0.0001-0.01) and TS (P <= 0.0001-0.04). Tetrastarch does not impair primary hemostasis and induces transient dilutional coagulopathy that is similar to LRS because, when compared to a 3 times higher volume of LRS in hemorrhaged dogs, it does not cause greater interference on the viscoelastic properties of the coagulum.
publishDate 2018
dc.date.none.fl_str_mv 2018-11-01
2019-10-04T18:33:47Z
2019-10-04T18:33:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/jvim.15327
Journal Of Veterinary Internal Medicine. Hoboken: Wiley, v. 32, n. 6, p. 1927-1933, 2018.
1939-1676
http://hdl.handle.net/11449/186291
10.1111/jvim.15327
WOS:000451827600015
url http://dx.doi.org/10.1111/jvim.15327
http://hdl.handle.net/11449/186291
identifier_str_mv Journal Of Veterinary Internal Medicine. Hoboken: Wiley, v. 32, n. 6, p. 1927-1933, 2018.
1939-1676
10.1111/jvim.15327
WOS:000451827600015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal Of Veterinary Internal Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1927-1933
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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