Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage

Detalhes bibliográficos
Autor(a) principal: Medina, Rebeca P.
Data de Publicação: 2018
Outros Autores: Araujo, Angela R., Andersen, Raymond J., Soares, Marcos A., Silva, Fabio de A., Silva, Dulce H. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1080/14786419.2018.1455037
http://hdl.handle.net/11449/177113
Resumo: Endophytic fungi were isolated from red alga Asparagopsis taxiformis - Falkenbergia stage, collected from the Brazilian coast, and were identified as Annulohypoxylon stygium (AT-03) and A. yungensis (AT-06) based on their macro/micromorphological and molecular features. Bioassay-guided fractionation of the EtOAc extract from laboratory cultures of both strains yielded known compounds pyrogallol from A. stygium, (3R)-scytalone and (3R,4R)-4-hydroxy-scytalone from A. yungensis. Pyrogallol was active against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli strains. An inactive fraction from A. stygium afforded two additional compounds, (3R,4R)-3,4,5-trihydroxy-1-tetralone and tyrosol. Optically active compounds had their stereochemistry determined by circular dichroism (CD) spectroscopy.
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spelling Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stageAnnulohypoxylonantimicrobial activityaromatic compoundsAsparagopsis taxiformisendophytic fungusMarine red algaEndophytic fungi were isolated from red alga Asparagopsis taxiformis - Falkenbergia stage, collected from the Brazilian coast, and were identified as Annulohypoxylon stygium (AT-03) and A. yungensis (AT-06) based on their macro/micromorphological and molecular features. Bioassay-guided fractionation of the EtOAc extract from laboratory cultures of both strains yielded known compounds pyrogallol from A. stygium, (3R)-scytalone and (3R,4R)-4-hydroxy-scytalone from A. yungensis. Pyrogallol was active against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli strains. An inactive fraction from A. stygium afforded two additional compounds, (3R,4R)-3,4,5-trihydroxy-1-tetralone and tyrosol. Optically active compounds had their stereochemistry determined by circular dichroism (CD) spectroscopy.Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE), Departamento de Química Orgânica, Instituto de Química, UNESP - Univ. Estadual Paulista, Araraquara, BrazilDepartment of Chemistry and Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, CanadaInstituto de Biociências, Universidade Federal de Mato Grosso, Cuiabá, BrazilUniversidade Estadual Paulista (Unesp)Medina, Rebeca P.Araujo, Angela R.Andersen, Raymond J.Soares, Marcos A.Silva, Fabio de A.Silva, Dulce H. S.2018-12-11T17:24:03Z2018-12-11T17:24:03Z2018-03-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-4application/pdfhttp://dx.doi.org/10.1080/14786419.2018.1455037Natural Product Research, p. 1-4.1478-64271478-6419http://hdl.handle.net/11449/17711310.1080/14786419.2018.14550372-s2.0-850444479692-s2.0-85044447969.pdf47020049042312480000-0002-1516-7765Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNatural Product Research0,671info:eu-repo/semantics/openAccess2023-11-19T06:09:55Zoai:repositorio.unesp.br:11449/177113Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:07:06.118796Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage
title Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage
spellingShingle Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage
Medina, Rebeca P.
Annulohypoxylon
antimicrobial activity
aromatic compounds
Asparagopsis taxiformis
endophytic fungus
Marine red alga
title_short Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage
title_full Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage
title_fullStr Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage
title_full_unstemmed Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage
title_sort Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage
author Medina, Rebeca P.
author_facet Medina, Rebeca P.
Araujo, Angela R.
Andersen, Raymond J.
Soares, Marcos A.
Silva, Fabio de A.
Silva, Dulce H. S.
author_role author
author2 Araujo, Angela R.
Andersen, Raymond J.
Soares, Marcos A.
Silva, Fabio de A.
Silva, Dulce H. S.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Medina, Rebeca P.
Araujo, Angela R.
Andersen, Raymond J.
Soares, Marcos A.
Silva, Fabio de A.
Silva, Dulce H. S.
dc.subject.por.fl_str_mv Annulohypoxylon
antimicrobial activity
aromatic compounds
Asparagopsis taxiformis
endophytic fungus
Marine red alga
topic Annulohypoxylon
antimicrobial activity
aromatic compounds
Asparagopsis taxiformis
endophytic fungus
Marine red alga
description Endophytic fungi were isolated from red alga Asparagopsis taxiformis - Falkenbergia stage, collected from the Brazilian coast, and were identified as Annulohypoxylon stygium (AT-03) and A. yungensis (AT-06) based on their macro/micromorphological and molecular features. Bioassay-guided fractionation of the EtOAc extract from laboratory cultures of both strains yielded known compounds pyrogallol from A. stygium, (3R)-scytalone and (3R,4R)-4-hydroxy-scytalone from A. yungensis. Pyrogallol was active against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli strains. An inactive fraction from A. stygium afforded two additional compounds, (3R,4R)-3,4,5-trihydroxy-1-tetralone and tyrosol. Optically active compounds had their stereochemistry determined by circular dichroism (CD) spectroscopy.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:24:03Z
2018-12-11T17:24:03Z
2018-03-25
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1080/14786419.2018.1455037
Natural Product Research, p. 1-4.
1478-6427
1478-6419
http://hdl.handle.net/11449/177113
10.1080/14786419.2018.1455037
2-s2.0-85044447969
2-s2.0-85044447969.pdf
4702004904231248
0000-0002-1516-7765
url http://dx.doi.org/10.1080/14786419.2018.1455037
http://hdl.handle.net/11449/177113
identifier_str_mv Natural Product Research, p. 1-4.
1478-6427
1478-6419
10.1080/14786419.2018.1455037
2-s2.0-85044447969
2-s2.0-85044447969.pdf
4702004904231248
0000-0002-1516-7765
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Natural Product Research
0,671
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-4
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128897440546816

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