Treatment of Laryngeal Granulomas
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1055/s-0039-1688456 http://hdl.handle.net/11449/186134 |
Resumo: | Introduction Laryngeal granulomas are benign, recurrent lesions of many causes (reflux, voice abuse, intubation, and idiopathic), which renders its treatment difficult. Objective To describe our experience in the treatment of laryngeal granulomas. Methods From 16 medical records of the patients with laryngeal granulomas seen between 2010 and 2017 in a university hospital, the following data were analyzed: age, gender, vocal and gastroesophageal symptoms, vocal overuse, intubation, treatments, videolaryngoscopy before and after the treatment. Results Gender: female, 10; male, 6. Age: between 20 and 60 years old (11). Etiology of the granulomas: intubation (9), reflux (4), idiopathic (3). The initial treatments adopted in all cases were: inhaled beclomethasone dipropionate 100 mu g 12/12 hours (1 month), proton pump inhibitor, omeprazole 40 mg/day (2 months), and dietary and voice education. After this period, 10 patients (7 postintubation, 3 idiopathic) were submitted to surgery, since no improvements in the symptoms or in the lesions were seen. Of these, two recurred, requiring a second surgery, one of which recurred six times and received botulinum toxin A. Only one patient with granulomas due to laryngopharyngeal reflux presented no improvement in the symptoms nor in the lesion after the pharmacological treatment and had been submitted to microsurgery. All of the other patients with reflux granulomas were successfully treated with the drug treatment, and the longest treatment time for complete remission of the symptoms and of the lesions was 9 months. Conclusions In laryngeal granulomas caused by reflux, treatment with inhaled steroids and proton pump inhibitors proved to be effective, although prolonged. In postintubation and idiopathic granulomas, surgery was the best treatment. |
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Treatment of Laryngeal GranulomasgranulomalarynxintubationtreatmentIntroduction Laryngeal granulomas are benign, recurrent lesions of many causes (reflux, voice abuse, intubation, and idiopathic), which renders its treatment difficult. Objective To describe our experience in the treatment of laryngeal granulomas. Methods From 16 medical records of the patients with laryngeal granulomas seen between 2010 and 2017 in a university hospital, the following data were analyzed: age, gender, vocal and gastroesophageal symptoms, vocal overuse, intubation, treatments, videolaryngoscopy before and after the treatment. Results Gender: female, 10; male, 6. Age: between 20 and 60 years old (11). Etiology of the granulomas: intubation (9), reflux (4), idiopathic (3). The initial treatments adopted in all cases were: inhaled beclomethasone dipropionate 100 mu g 12/12 hours (1 month), proton pump inhibitor, omeprazole 40 mg/day (2 months), and dietary and voice education. After this period, 10 patients (7 postintubation, 3 idiopathic) were submitted to surgery, since no improvements in the symptoms or in the lesions were seen. Of these, two recurred, requiring a second surgery, one of which recurred six times and received botulinum toxin A. Only one patient with granulomas due to laryngopharyngeal reflux presented no improvement in the symptoms nor in the lesion after the pharmacological treatment and had been submitted to microsurgery. All of the other patients with reflux granulomas were successfully treated with the drug treatment, and the longest treatment time for complete remission of the symptoms and of the lesions was 9 months. Conclusions In laryngeal granulomas caused by reflux, treatment with inhaled steroids and proton pump inhibitors proved to be effective, although prolonged. In postintubation and idiopathic granulomas, surgery was the best treatment.Univ Estadual Paulista, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Botucatu Med Sch, Sao Paulo, SP, BrazilUniv Estadual Paulista, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, Botucatu Med Sch, Sao Paulo, SP, BrazilGeorg Thieme Verlag KgUniversidade Estadual Paulista (Unesp)Garcia Martins, Regina Helena [UNESP]Dias, Norimar Hernandes [UNESP]Paiva Soares, Carlos Segundo [UNESP]Joia Gramuglia, Andrea Cristina [UNESP]2019-10-04T12:41:35Z2019-10-04T12:41:35Z2019-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleE322-E324application/pdfhttp://dx.doi.org/10.1055/s-0039-1688456International Archives Of Otorhinolaryngology. Stuttgart: Georg Thieme Verlag Kg, v. 23, n. 3, p. E322-E324, 2019.1809-9777http://hdl.handle.net/11449/18613410.1055/s-0039-1688456S1809-48642019000300322WOS:000484129200013S1809-48642019000300322.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Archives Of Otorhinolaryngologyinfo:eu-repo/semantics/openAccess2023-11-05T06:05:55Zoai:repositorio.unesp.br:11449/186134Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-11-05T06:05:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Treatment of Laryngeal Granulomas |
title |
Treatment of Laryngeal Granulomas |
spellingShingle |
Treatment of Laryngeal Granulomas Garcia Martins, Regina Helena [UNESP] granuloma larynx intubation treatment |
title_short |
Treatment of Laryngeal Granulomas |
title_full |
Treatment of Laryngeal Granulomas |
title_fullStr |
Treatment of Laryngeal Granulomas |
title_full_unstemmed |
Treatment of Laryngeal Granulomas |
title_sort |
Treatment of Laryngeal Granulomas |
author |
Garcia Martins, Regina Helena [UNESP] |
author_facet |
Garcia Martins, Regina Helena [UNESP] Dias, Norimar Hernandes [UNESP] Paiva Soares, Carlos Segundo [UNESP] Joia Gramuglia, Andrea Cristina [UNESP] |
author_role |
author |
author2 |
Dias, Norimar Hernandes [UNESP] Paiva Soares, Carlos Segundo [UNESP] Joia Gramuglia, Andrea Cristina [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Garcia Martins, Regina Helena [UNESP] Dias, Norimar Hernandes [UNESP] Paiva Soares, Carlos Segundo [UNESP] Joia Gramuglia, Andrea Cristina [UNESP] |
dc.subject.por.fl_str_mv |
granuloma larynx intubation treatment |
topic |
granuloma larynx intubation treatment |
description |
Introduction Laryngeal granulomas are benign, recurrent lesions of many causes (reflux, voice abuse, intubation, and idiopathic), which renders its treatment difficult. Objective To describe our experience in the treatment of laryngeal granulomas. Methods From 16 medical records of the patients with laryngeal granulomas seen between 2010 and 2017 in a university hospital, the following data were analyzed: age, gender, vocal and gastroesophageal symptoms, vocal overuse, intubation, treatments, videolaryngoscopy before and after the treatment. Results Gender: female, 10; male, 6. Age: between 20 and 60 years old (11). Etiology of the granulomas: intubation (9), reflux (4), idiopathic (3). The initial treatments adopted in all cases were: inhaled beclomethasone dipropionate 100 mu g 12/12 hours (1 month), proton pump inhibitor, omeprazole 40 mg/day (2 months), and dietary and voice education. After this period, 10 patients (7 postintubation, 3 idiopathic) were submitted to surgery, since no improvements in the symptoms or in the lesions were seen. Of these, two recurred, requiring a second surgery, one of which recurred six times and received botulinum toxin A. Only one patient with granulomas due to laryngopharyngeal reflux presented no improvement in the symptoms nor in the lesion after the pharmacological treatment and had been submitted to microsurgery. All of the other patients with reflux granulomas were successfully treated with the drug treatment, and the longest treatment time for complete remission of the symptoms and of the lesions was 9 months. Conclusions In laryngeal granulomas caused by reflux, treatment with inhaled steroids and proton pump inhibitors proved to be effective, although prolonged. In postintubation and idiopathic granulomas, surgery was the best treatment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-04T12:41:35Z 2019-10-04T12:41:35Z 2019-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1055/s-0039-1688456 International Archives Of Otorhinolaryngology. Stuttgart: Georg Thieme Verlag Kg, v. 23, n. 3, p. E322-E324, 2019. 1809-9777 http://hdl.handle.net/11449/186134 10.1055/s-0039-1688456 S1809-48642019000300322 WOS:000484129200013 S1809-48642019000300322.pdf |
url |
http://dx.doi.org/10.1055/s-0039-1688456 http://hdl.handle.net/11449/186134 |
identifier_str_mv |
International Archives Of Otorhinolaryngology. Stuttgart: Georg Thieme Verlag Kg, v. 23, n. 3, p. E322-E324, 2019. 1809-9777 10.1055/s-0039-1688456 S1809-48642019000300322 WOS:000484129200013 S1809-48642019000300322.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Archives Of Otorhinolaryngology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
E322-E324 application/pdf |
dc.publisher.none.fl_str_mv |
Georg Thieme Verlag Kg |
publisher.none.fl_str_mv |
Georg Thieme Verlag Kg |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964822103654400 |