Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10973-015-4826-3 http://hdl.handle.net/11449/172591 |
Resumo: | Praziquantel is an anthelmintic widely used in the treatment of schistosomiasis. Although a highly permeable drug, praziquantel is poorly soluble in water, limiting its bioavailability. Improving the solubility of poorly water-soluble drugs has become an important issue for analysis in pharmaceutical research. The use of dextran hydrogels is an advantageous strategy and the focus of extensive research. In this study, several hydrogels were developed from homologous polymer blends using 70 and 148 kDa dextrans in different proportions containing praziquantel, with the aim of evaluating the effects of polymeric release systems on the solubility of poorly water-soluble drugs such as praziquantel. Nine formulations were prepared, and the solubility of the drug incorporated was assessed. Three of the formations were selected to be characterized by DSC for the study in order to gain a better understanding of the thermal behavior of praziquantel incorporated into dextran hydrogels and the influence of polymers on the solubility of the drug, complemented by XRD and SEM techniques. According to the results, formation of crystallites of praziquantel occurred, probably due to the preparation procedures of the formulations, covering the surface of the polymer matrix and promoting a slight improvement in solubility. These data show that the use of hydrogels for the purposes of improving the solubility of poorly water-soluble drugs represents an effective strategy. |
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Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubilityDextranHomologous polymer blendHydrogelsPraziquantelSolubilityThermal analysisPraziquantel is an anthelmintic widely used in the treatment of schistosomiasis. Although a highly permeable drug, praziquantel is poorly soluble in water, limiting its bioavailability. Improving the solubility of poorly water-soluble drugs has become an important issue for analysis in pharmaceutical research. The use of dextran hydrogels is an advantageous strategy and the focus of extensive research. In this study, several hydrogels were developed from homologous polymer blends using 70 and 148 kDa dextrans in different proportions containing praziquantel, with the aim of evaluating the effects of polymeric release systems on the solubility of poorly water-soluble drugs such as praziquantel. Nine formulations were prepared, and the solubility of the drug incorporated was assessed. Three of the formations were selected to be characterized by DSC for the study in order to gain a better understanding of the thermal behavior of praziquantel incorporated into dextran hydrogels and the influence of polymers on the solubility of the drug, complemented by XRD and SEM techniques. According to the results, formation of crystallites of praziquantel occurred, probably due to the preparation procedures of the formulations, covering the surface of the polymer matrix and promoting a slight improvement in solubility. These data show that the use of hydrogels for the purposes of improving the solubility of poorly water-soluble drugs represents an effective strategy.School of Pharmaceutical Sciences UNESP Univ Estadual PaulistaInstitute of Chemistry UNESP Univ Estadual PaulistaDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University UNESP, Rodovia Araraquara-Jaú, km 1School of Pharmaceutical Sciences UNESP Univ Estadual PaulistaInstitute of Chemistry UNESP Univ Estadual PaulistaDepartment of Drugs and Pharmaceuticals School of Pharmaceutical Sciences São Paulo State University UNESP, Rodovia Araraquara-Jaú, km 1Universidade Estadual Paulista (Unesp)Campos, Flávio Dos Santos [UNESP]Ferrari, Laís Zuzzi [UNESP]Cassimiro, Douglas Lopes [UNESP]Ribeiro, Clóvis Augusto [UNESP]De Almeida, Adélia Emilia [UNESP]Gremião, Maria Palmira Daflon [UNESP]2018-12-11T17:01:15Z2018-12-11T17:01:15Z2016-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2157-2164application/pdfhttp://dx.doi.org/10.1007/s10973-015-4826-3Journal of Thermal Analysis and Calorimetry, v. 123, n. 3, p. 2157-2164, 2016.1588-29261388-6150http://hdl.handle.net/11449/17259110.1007/s10973-015-4826-32-s2.0-849591989782-s2.0-84959198978.pdf912978053672425684983108918100820000-0002-7984-5908Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Thermal Analysis and Calorimetry0,5870,587info:eu-repo/semantics/openAccess2024-06-24T13:45:50Zoai:repositorio.unesp.br:11449/172591Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:34:41.450780Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility |
title |
Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility |
spellingShingle |
Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility Campos, Flávio Dos Santos [UNESP] Dextran Homologous polymer blend Hydrogels Praziquantel Solubility Thermal analysis |
title_short |
Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility |
title_full |
Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility |
title_fullStr |
Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility |
title_full_unstemmed |
Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility |
title_sort |
Effect of 70-kDa and 148-kDa dextran hydrogels on praziquantel solubility |
author |
Campos, Flávio Dos Santos [UNESP] |
author_facet |
Campos, Flávio Dos Santos [UNESP] Ferrari, Laís Zuzzi [UNESP] Cassimiro, Douglas Lopes [UNESP] Ribeiro, Clóvis Augusto [UNESP] De Almeida, Adélia Emilia [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
author_role |
author |
author2 |
Ferrari, Laís Zuzzi [UNESP] Cassimiro, Douglas Lopes [UNESP] Ribeiro, Clóvis Augusto [UNESP] De Almeida, Adélia Emilia [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Campos, Flávio Dos Santos [UNESP] Ferrari, Laís Zuzzi [UNESP] Cassimiro, Douglas Lopes [UNESP] Ribeiro, Clóvis Augusto [UNESP] De Almeida, Adélia Emilia [UNESP] Gremião, Maria Palmira Daflon [UNESP] |
dc.subject.por.fl_str_mv |
Dextran Homologous polymer blend Hydrogels Praziquantel Solubility Thermal analysis |
topic |
Dextran Homologous polymer blend Hydrogels Praziquantel Solubility Thermal analysis |
description |
Praziquantel is an anthelmintic widely used in the treatment of schistosomiasis. Although a highly permeable drug, praziquantel is poorly soluble in water, limiting its bioavailability. Improving the solubility of poorly water-soluble drugs has become an important issue for analysis in pharmaceutical research. The use of dextran hydrogels is an advantageous strategy and the focus of extensive research. In this study, several hydrogels were developed from homologous polymer blends using 70 and 148 kDa dextrans in different proportions containing praziquantel, with the aim of evaluating the effects of polymeric release systems on the solubility of poorly water-soluble drugs such as praziquantel. Nine formulations were prepared, and the solubility of the drug incorporated was assessed. Three of the formations were selected to be characterized by DSC for the study in order to gain a better understanding of the thermal behavior of praziquantel incorporated into dextran hydrogels and the influence of polymers on the solubility of the drug, complemented by XRD and SEM techniques. According to the results, formation of crystallites of praziquantel occurred, probably due to the preparation procedures of the formulations, covering the surface of the polymer matrix and promoting a slight improvement in solubility. These data show that the use of hydrogels for the purposes of improving the solubility of poorly water-soluble drugs represents an effective strategy. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03-01 2018-12-11T17:01:15Z 2018-12-11T17:01:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10973-015-4826-3 Journal of Thermal Analysis and Calorimetry, v. 123, n. 3, p. 2157-2164, 2016. 1588-2926 1388-6150 http://hdl.handle.net/11449/172591 10.1007/s10973-015-4826-3 2-s2.0-84959198978 2-s2.0-84959198978.pdf 9129780536724256 8498310891810082 0000-0002-7984-5908 |
url |
http://dx.doi.org/10.1007/s10973-015-4826-3 http://hdl.handle.net/11449/172591 |
identifier_str_mv |
Journal of Thermal Analysis and Calorimetry, v. 123, n. 3, p. 2157-2164, 2016. 1588-2926 1388-6150 10.1007/s10973-015-4826-3 2-s2.0-84959198978 2-s2.0-84959198978.pdf 9129780536724256 8498310891810082 0000-0002-7984-5908 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Thermal Analysis and Calorimetry 0,587 0,587 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2157-2164 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128951307993088 |