Effects of physical training on the immune system in diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4103/0973-3930.60010 http://hdl.handle.net/11449/20759 |
Resumo: | Aims: This study aims to investigate the influence of physical training on the immune system of diabetic rats. Materials and Methods: Adult male Wistar rats were distributed into Sedentary Control (SC), Trained Control (TC), Sedentary Diabetic (SD) and Trained Diabetic (TD) groups were used. Diabetes was induced by alloxan (32 mg/bw-i.v.). Training protocol consisted of swimming, at 32 18C, one hour/day, five days/week, supporting an overload equivalent to 5 of the body weight, during four weeks. At the end of the experiment the rats were sacrificed by decapitation and blood samples were collected for glucose, insulin, albumin, hematocrit determinations, total and differential leukocyte counting. Additionally, liver samples for glycogen analyses were obtained. Results: The results were analyzed by one way at a significance level of 5. Diabetes reduced blood insulin, liver glycogen stores and increased blood glucose and neutrophil count. Physical training restored glycemia, liver glycogen levels, neutrophils and lymphocytes count in diabetic rats. Conclusions: In summary, physical training was able to improve metabolic and immunological aspects in the experimental diabetic rats. |
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Repositório Institucional da UNESP |
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Effects of physical training on the immune system in diabetic ratsPhysical trainingimmune systemmetabolism and diabetes mellitusAims: This study aims to investigate the influence of physical training on the immune system of diabetic rats. Materials and Methods: Adult male Wistar rats were distributed into Sedentary Control (SC), Trained Control (TC), Sedentary Diabetic (SD) and Trained Diabetic (TD) groups were used. Diabetes was induced by alloxan (32 mg/bw-i.v.). Training protocol consisted of swimming, at 32 18C, one hour/day, five days/week, supporting an overload equivalent to 5 of the body weight, during four weeks. At the end of the experiment the rats were sacrificed by decapitation and blood samples were collected for glucose, insulin, albumin, hematocrit determinations, total and differential leukocyte counting. Additionally, liver samples for glycogen analyses were obtained. Results: The results were analyzed by one way at a significance level of 5. Diabetes reduced blood insulin, liver glycogen stores and increased blood glucose and neutrophil count. Physical training restored glycemia, liver glycogen levels, neutrophils and lymphocytes count in diabetic rats. Conclusions: In summary, physical training was able to improve metabolic and immunological aspects in the experimental diabetic rats.UNESP, São Paulo State Univ, Dept Phys Educ, Rio Claro, SP, BrazilUNESP, São Paulo State Univ, Dept Phys Educ, Rio Claro, SP, BrazilMedknow PublicationsUniversidade Estadual Paulista (Unesp)Crespilho, Daniel Maciel [UNESP]Curiacos de Almeida Leme, Jose Alexandre [UNESP]Rostom de Mello, Maria Alice [UNESP]Luciano, Eliete [UNESP]2013-09-30T18:48:42Z2014-05-20T13:58:26Z2013-09-30T18:48:42Z2014-05-20T13:58:26Z2010-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article33-37http://dx.doi.org/10.4103/0973-3930.60010International Journal of Diabetes In Developing Countries. Mumbai: Medknow Publications, v. 30, n. 1, p. 33-37, 2010.0973-3930http://hdl.handle.net/11449/2075910.4103/0973-3930.60010WOS:0002756538000072933779830637191Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Diabetes In Developing Countries0.3610,173info:eu-repo/semantics/openAccess2021-10-23T11:21:31Zoai:repositorio.unesp.br:11449/20759Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:49:09.190397Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of physical training on the immune system in diabetic rats |
title |
Effects of physical training on the immune system in diabetic rats |
spellingShingle |
Effects of physical training on the immune system in diabetic rats Crespilho, Daniel Maciel [UNESP] Physical training immune system metabolism and diabetes mellitus |
title_short |
Effects of physical training on the immune system in diabetic rats |
title_full |
Effects of physical training on the immune system in diabetic rats |
title_fullStr |
Effects of physical training on the immune system in diabetic rats |
title_full_unstemmed |
Effects of physical training on the immune system in diabetic rats |
title_sort |
Effects of physical training on the immune system in diabetic rats |
author |
Crespilho, Daniel Maciel [UNESP] |
author_facet |
Crespilho, Daniel Maciel [UNESP] Curiacos de Almeida Leme, Jose Alexandre [UNESP] Rostom de Mello, Maria Alice [UNESP] Luciano, Eliete [UNESP] |
author_role |
author |
author2 |
Curiacos de Almeida Leme, Jose Alexandre [UNESP] Rostom de Mello, Maria Alice [UNESP] Luciano, Eliete [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Crespilho, Daniel Maciel [UNESP] Curiacos de Almeida Leme, Jose Alexandre [UNESP] Rostom de Mello, Maria Alice [UNESP] Luciano, Eliete [UNESP] |
dc.subject.por.fl_str_mv |
Physical training immune system metabolism and diabetes mellitus |
topic |
Physical training immune system metabolism and diabetes mellitus |
description |
Aims: This study aims to investigate the influence of physical training on the immune system of diabetic rats. Materials and Methods: Adult male Wistar rats were distributed into Sedentary Control (SC), Trained Control (TC), Sedentary Diabetic (SD) and Trained Diabetic (TD) groups were used. Diabetes was induced by alloxan (32 mg/bw-i.v.). Training protocol consisted of swimming, at 32 18C, one hour/day, five days/week, supporting an overload equivalent to 5 of the body weight, during four weeks. At the end of the experiment the rats were sacrificed by decapitation and blood samples were collected for glucose, insulin, albumin, hematocrit determinations, total and differential leukocyte counting. Additionally, liver samples for glycogen analyses were obtained. Results: The results were analyzed by one way at a significance level of 5. Diabetes reduced blood insulin, liver glycogen stores and increased blood glucose and neutrophil count. Physical training restored glycemia, liver glycogen levels, neutrophils and lymphocytes count in diabetic rats. Conclusions: In summary, physical training was able to improve metabolic and immunological aspects in the experimental diabetic rats. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 2013-09-30T18:48:42Z 2013-09-30T18:48:42Z 2014-05-20T13:58:26Z 2014-05-20T13:58:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4103/0973-3930.60010 International Journal of Diabetes In Developing Countries. Mumbai: Medknow Publications, v. 30, n. 1, p. 33-37, 2010. 0973-3930 http://hdl.handle.net/11449/20759 10.4103/0973-3930.60010 WOS:000275653800007 2933779830637191 |
url |
http://dx.doi.org/10.4103/0973-3930.60010 http://hdl.handle.net/11449/20759 |
identifier_str_mv |
International Journal of Diabetes In Developing Countries. Mumbai: Medknow Publications, v. 30, n. 1, p. 33-37, 2010. 0973-3930 10.4103/0973-3930.60010 WOS:000275653800007 2933779830637191 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Diabetes In Developing Countries 0.361 0,173 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
33-37 |
dc.publisher.none.fl_str_mv |
Medknow Publications |
publisher.none.fl_str_mv |
Medknow Publications |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129252766253056 |