Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation
Autor(a) principal: | |
---|---|
Data de Publicação: | 2004 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1806-83242004000200006 http://hdl.handle.net/11449/67697 |
Resumo: | The aim of the present parallel, double-blind investigation was to evaluate the effect of using systemic metronidazole alone or associated to scaling and root planing on adult chronic periodontal disease, monitored at baseline, 30, 60 and 90 days. Twelve subjects were divided into three groups: the first group (Group I - 22 sites) was submitted to scaling and root planing (SRP) alone; the second group (Group II - 30 sites) received SRP and 250 mg of metronidazole (3 times a day for 10 days), and the third group (Group III - 31 sites) was treated with metronidazole alone. The clinical parameters evaluated were probing depth (PD), clinical attachment level (CAL), plaque index (PlI), gingival index (GI) and bleeding upon probing (BP). Microbiological (BANA test) and enzymatic (Pocket Watch) tests were also performed. All three proposed treatments produced significant improvements in clinical conditions of subjects, from baseline, 30, 60 and 90-day period, except for clinical attachment level. The results obtained by microbiological and enzymatic tests did not show statistical differences among the groups for the 90-day period (r = 0.7924 and r = 0.7757, respectively). In relation to clinical parameters, statistical differences among groups were observed only for the gingival index (p = 0.0261) between Groups I and II, and probing depth (p = 0.0124) between Group I and the others. We conclude that the use of systemic metronidazole did not produce additional effects on the microbiological conditions of these patients with chronic periodontal disease. |
id |
UNSP_48021301a61dfc995154e2de256ce0e5 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/67697 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluationantiinfective agentmetronidazoleadultanalysis of variancechronic diseaseclinical trialcontrolled clinical trialcontrolled studydouble blind procedureenzyme assayfemalehumanmalemicrobiologymultimodality cancer therapyperiodonticsperiodontitispilot studypreventive dentistrytooth plaqueAdultAnalysis of VarianceAnti-Infective AgentsChronic DiseaseCombined Modality TherapyDental Plaque IndexDouble-Blind MethodEnzyme TestsFemaleHumansMaleMetronidazolePeriodontal IndexPeriodontitisPilot ProjectsRoot PlaningThe aim of the present parallel, double-blind investigation was to evaluate the effect of using systemic metronidazole alone or associated to scaling and root planing on adult chronic periodontal disease, monitored at baseline, 30, 60 and 90 days. Twelve subjects were divided into three groups: the first group (Group I - 22 sites) was submitted to scaling and root planing (SRP) alone; the second group (Group II - 30 sites) received SRP and 250 mg of metronidazole (3 times a day for 10 days), and the third group (Group III - 31 sites) was treated with metronidazole alone. The clinical parameters evaluated were probing depth (PD), clinical attachment level (CAL), plaque index (PlI), gingival index (GI) and bleeding upon probing (BP). Microbiological (BANA test) and enzymatic (Pocket Watch) tests were also performed. All three proposed treatments produced significant improvements in clinical conditions of subjects, from baseline, 30, 60 and 90-day period, except for clinical attachment level. The results obtained by microbiological and enzymatic tests did not show statistical differences among the groups for the 90-day period (r = 0.7924 and r = 0.7757, respectively). In relation to clinical parameters, statistical differences among groups were observed only for the gingival index (p = 0.0261) between Groups I and II, and probing depth (p = 0.0124) between Group I and the others. We conclude that the use of systemic metronidazole did not produce additional effects on the microbiological conditions of these patients with chronic periodontal disease.Universidade Estadual Paulista (Unesp)Vergani, Solange Alonso [UNESP]Silva, Emílio Barbosa eVinholis, Adriana HelenaMarcantonio, Rosemary Adriana Chierici [UNESP]2014-05-27T11:21:03Z2014-05-27T11:21:03Z2004-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article121-127application/pdfhttp://dx.doi.org/10.1590/S1806-83242004000200006Pesquisa odontológica brasileira = Brazilian oral research, v. 18, n. 2, p. 121-127, 2004.1806-8324http://hdl.handle.net/11449/6769710.1590/S1806-83242004000200006S1806-832420040002000062-s2.0-166443676302-s2.0-16644367630.pdf3534044399884035Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPesquisa Odontológica Brasileira = Brazilian Oral Researchinfo:eu-repo/semantics/openAccess2023-11-30T06:17:52Zoai:repositorio.unesp.br:11449/67697Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:09:39.119173Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation |
title |
Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation |
spellingShingle |
Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation Vergani, Solange Alonso [UNESP] antiinfective agent metronidazole adult analysis of variance chronic disease clinical trial controlled clinical trial controlled study double blind procedure enzyme assay female human male microbiology multimodality cancer therapy periodontics periodontitis pilot study preventive dentistry tooth plaque Adult Analysis of Variance Anti-Infective Agents Chronic Disease Combined Modality Therapy Dental Plaque Index Double-Blind Method Enzyme Tests Female Humans Male Metronidazole Periodontal Index Periodontitis Pilot Projects Root Planing |
title_short |
Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation |
title_full |
Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation |
title_fullStr |
Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation |
title_full_unstemmed |
Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation |
title_sort |
Systemic use of metronidazole in the treatment of chronic periodontitis: a pilot study using clinical, microbiological, and enzymatic evaluation |
author |
Vergani, Solange Alonso [UNESP] |
author_facet |
Vergani, Solange Alonso [UNESP] Silva, Emílio Barbosa e Vinholis, Adriana Helena Marcantonio, Rosemary Adriana Chierici [UNESP] |
author_role |
author |
author2 |
Silva, Emílio Barbosa e Vinholis, Adriana Helena Marcantonio, Rosemary Adriana Chierici [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Vergani, Solange Alonso [UNESP] Silva, Emílio Barbosa e Vinholis, Adriana Helena Marcantonio, Rosemary Adriana Chierici [UNESP] |
dc.subject.por.fl_str_mv |
antiinfective agent metronidazole adult analysis of variance chronic disease clinical trial controlled clinical trial controlled study double blind procedure enzyme assay female human male microbiology multimodality cancer therapy periodontics periodontitis pilot study preventive dentistry tooth plaque Adult Analysis of Variance Anti-Infective Agents Chronic Disease Combined Modality Therapy Dental Plaque Index Double-Blind Method Enzyme Tests Female Humans Male Metronidazole Periodontal Index Periodontitis Pilot Projects Root Planing |
topic |
antiinfective agent metronidazole adult analysis of variance chronic disease clinical trial controlled clinical trial controlled study double blind procedure enzyme assay female human male microbiology multimodality cancer therapy periodontics periodontitis pilot study preventive dentistry tooth plaque Adult Analysis of Variance Anti-Infective Agents Chronic Disease Combined Modality Therapy Dental Plaque Index Double-Blind Method Enzyme Tests Female Humans Male Metronidazole Periodontal Index Periodontitis Pilot Projects Root Planing |
description |
The aim of the present parallel, double-blind investigation was to evaluate the effect of using systemic metronidazole alone or associated to scaling and root planing on adult chronic periodontal disease, monitored at baseline, 30, 60 and 90 days. Twelve subjects were divided into three groups: the first group (Group I - 22 sites) was submitted to scaling and root planing (SRP) alone; the second group (Group II - 30 sites) received SRP and 250 mg of metronidazole (3 times a day for 10 days), and the third group (Group III - 31 sites) was treated with metronidazole alone. The clinical parameters evaluated were probing depth (PD), clinical attachment level (CAL), plaque index (PlI), gingival index (GI) and bleeding upon probing (BP). Microbiological (BANA test) and enzymatic (Pocket Watch) tests were also performed. All three proposed treatments produced significant improvements in clinical conditions of subjects, from baseline, 30, 60 and 90-day period, except for clinical attachment level. The results obtained by microbiological and enzymatic tests did not show statistical differences among the groups for the 90-day period (r = 0.7924 and r = 0.7757, respectively). In relation to clinical parameters, statistical differences among groups were observed only for the gingival index (p = 0.0261) between Groups I and II, and probing depth (p = 0.0124) between Group I and the others. We conclude that the use of systemic metronidazole did not produce additional effects on the microbiological conditions of these patients with chronic periodontal disease. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-04-01 2014-05-27T11:21:03Z 2014-05-27T11:21:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1806-83242004000200006 Pesquisa odontológica brasileira = Brazilian oral research, v. 18, n. 2, p. 121-127, 2004. 1806-8324 http://hdl.handle.net/11449/67697 10.1590/S1806-83242004000200006 S1806-83242004000200006 2-s2.0-16644367630 2-s2.0-16644367630.pdf 3534044399884035 |
url |
http://dx.doi.org/10.1590/S1806-83242004000200006 http://hdl.handle.net/11449/67697 |
identifier_str_mv |
Pesquisa odontológica brasileira = Brazilian oral research, v. 18, n. 2, p. 121-127, 2004. 1806-8324 10.1590/S1806-83242004000200006 S1806-83242004000200006 2-s2.0-16644367630 2-s2.0-16644367630.pdf 3534044399884035 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pesquisa Odontológica Brasileira = Brazilian Oral Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
121-127 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129027998744576 |