Pathophysiology of mesenteric ischemia/reperfusion: a review.

Detalhes bibliográficos
Autor(a) principal: Cerqueira, Nereide Freire
Data de Publicação: 2005
Outros Autores: Hussni, Carlos Alberto [UNESP], Yoshida, Winston Bonetti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502005000400013
http://hdl.handle.net/11449/68306
Resumo: During ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R) have not been completely defined and many studies have been realized in an attempt to find an ideal therapy for mesenteric I/R. The occlusion and reperfusion of the splanchnic arteries provokes local and systemic alterations principally derived from the release of cytotoxic substances and the interaction between neutrophils and endothelial cells. Substances involved in the process are discussed in the present review, like oxygen-derived free radicals, nitric oxide, transcription factors, complement system, serotonin and pancreatic proteases. The mechanisms of apoptosis, alterations in other organs, therapeutic and evaluation methods are also discussed.
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spelling Pathophysiology of mesenteric ischemia/reperfusion: a review.reactive oxygen metabolitehumanintestineischemiamesenterypathologypathophysiologyperitoneal diseasereperfusion injuryreviewvascularizationHumansIntestinesIschemiaMesenteryPeritoneal DiseasesReactive Oxygen SpeciesReperfusion InjuryDuring ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R) have not been completely defined and many studies have been realized in an attempt to find an ideal therapy for mesenteric I/R. The occlusion and reperfusion of the splanchnic arteries provokes local and systemic alterations principally derived from the release of cytotoxic substances and the interaction between neutrophils and endothelial cells. Substances involved in the process are discussed in the present review, like oxygen-derived free radicals, nitric oxide, transcription factors, complement system, serotonin and pancreatic proteases. The mechanisms of apoptosis, alterations in other organs, therapeutic and evaluation methods are also discussed.Universidade Estadual Paulista (Unesp)Cerqueira, Nereide FreireHussni, Carlos Alberto [UNESP]Yoshida, Winston Bonetti2014-05-27T11:21:22Z2014-05-27T11:21:22Z2005-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article336-343application/pdfhttp://dx.doi.org/10.1590/S0102-86502005000400013Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia., v. 20, n. 4, p. 336-343, 2005.0102-8650http://hdl.handle.net/11449/6830610.1590/S0102-86502005000400013S0102-865020050004000132-s2.0-336458953092-s2.0-33645895309.pdf6020984937849801Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirúrgica Brasileira0.9330,395info:eu-repo/semantics/openAccess2023-10-03T06:07:12Zoai:repositorio.unesp.br:11449/68306Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:55:57.544307Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pathophysiology of mesenteric ischemia/reperfusion: a review.
title Pathophysiology of mesenteric ischemia/reperfusion: a review.
spellingShingle Pathophysiology of mesenteric ischemia/reperfusion: a review.
Cerqueira, Nereide Freire
reactive oxygen metabolite
human
intestine
ischemia
mesentery
pathology
pathophysiology
peritoneal disease
reperfusion injury
review
vascularization
Humans
Intestines
Ischemia
Mesentery
Peritoneal Diseases
Reactive Oxygen Species
Reperfusion Injury
title_short Pathophysiology of mesenteric ischemia/reperfusion: a review.
title_full Pathophysiology of mesenteric ischemia/reperfusion: a review.
title_fullStr Pathophysiology of mesenteric ischemia/reperfusion: a review.
title_full_unstemmed Pathophysiology of mesenteric ischemia/reperfusion: a review.
title_sort Pathophysiology of mesenteric ischemia/reperfusion: a review.
author Cerqueira, Nereide Freire
author_facet Cerqueira, Nereide Freire
Hussni, Carlos Alberto [UNESP]
Yoshida, Winston Bonetti
author_role author
author2 Hussni, Carlos Alberto [UNESP]
Yoshida, Winston Bonetti
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Cerqueira, Nereide Freire
Hussni, Carlos Alberto [UNESP]
Yoshida, Winston Bonetti
dc.subject.por.fl_str_mv reactive oxygen metabolite
human
intestine
ischemia
mesentery
pathology
pathophysiology
peritoneal disease
reperfusion injury
review
vascularization
Humans
Intestines
Ischemia
Mesentery
Peritoneal Diseases
Reactive Oxygen Species
Reperfusion Injury
topic reactive oxygen metabolite
human
intestine
ischemia
mesentery
pathology
pathophysiology
peritoneal disease
reperfusion injury
review
vascularization
Humans
Intestines
Ischemia
Mesentery
Peritoneal Diseases
Reactive Oxygen Species
Reperfusion Injury
description During ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R) have not been completely defined and many studies have been realized in an attempt to find an ideal therapy for mesenteric I/R. The occlusion and reperfusion of the splanchnic arteries provokes local and systemic alterations principally derived from the release of cytotoxic substances and the interaction between neutrophils and endothelial cells. Substances involved in the process are discussed in the present review, like oxygen-derived free radicals, nitric oxide, transcription factors, complement system, serotonin and pancreatic proteases. The mechanisms of apoptosis, alterations in other organs, therapeutic and evaluation methods are also discussed.
publishDate 2005
dc.date.none.fl_str_mv 2005-07-01
2014-05-27T11:21:22Z
2014-05-27T11:21:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502005000400013
Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia., v. 20, n. 4, p. 336-343, 2005.
0102-8650
http://hdl.handle.net/11449/68306
10.1590/S0102-86502005000400013
S0102-86502005000400013
2-s2.0-33645895309
2-s2.0-33645895309.pdf
6020984937849801
url http://dx.doi.org/10.1590/S0102-86502005000400013
http://hdl.handle.net/11449/68306
identifier_str_mv Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia., v. 20, n. 4, p. 336-343, 2005.
0102-8650
10.1590/S0102-86502005000400013
S0102-86502005000400013
2-s2.0-33645895309
2-s2.0-33645895309.pdf
6020984937849801
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirúrgica Brasileira
0.933
0,395
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 336-343
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128291474767872

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