Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ceramint.2022.06.266 http://hdl.handle.net/11449/240424 |
Resumo: | The biomedical engineering advances in the last years have been rising demand for multifunctional biomaterials. Bioactive glass (BG) submicron particles are potential candidates for the formulation of composites with improved dispersion and homogeneity between the constituents. This work presents the preparation of SiO2–Na2O–CaO–P2O5 glass-derived powders composed of particles with homogenous shapes and sizes between 300 and 500 nm. Two types of synthesis were employed for the preparation of the BG powders, the melt-quenching method, and a citric acid-assisted sol-gel route at a low citric acid concentration (0.005 mol L−1). The morphology of the particles was achieved by a low-energy process using a ball mill. These powders were characterized for their structure and surface area and evaluated for in vitro mineralization and antibacterial behavior. X-ray diffraction (XRD) analysis revealed different crystalline silicate phases in the sol-gel-derived powder and confirmed the amorphous structure of the melt-quenching-derived one. The surface of the particles was covered by hydroxycarbonate-apatite (HCA) after five days in simulated body fluid (SBF). The antibacterial activity against Staphylococcus aureus was higher for the sol-gel-derived powder, showing inhibition >99% of the bacteria growth in 24 h for all concentrations studied. These BG-based powders present a set of characteristics useful for the formulation of multifunctional composites for orthopedic applications. |
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Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activityAntimicrobial glassBioactive glass-ceramic particlesIon releaseMineralizationThe biomedical engineering advances in the last years have been rising demand for multifunctional biomaterials. Bioactive glass (BG) submicron particles are potential candidates for the formulation of composites with improved dispersion and homogeneity between the constituents. This work presents the preparation of SiO2–Na2O–CaO–P2O5 glass-derived powders composed of particles with homogenous shapes and sizes between 300 and 500 nm. Two types of synthesis were employed for the preparation of the BG powders, the melt-quenching method, and a citric acid-assisted sol-gel route at a low citric acid concentration (0.005 mol L−1). The morphology of the particles was achieved by a low-energy process using a ball mill. These powders were characterized for their structure and surface area and evaluated for in vitro mineralization and antibacterial behavior. X-ray diffraction (XRD) analysis revealed different crystalline silicate phases in the sol-gel-derived powder and confirmed the amorphous structure of the melt-quenching-derived one. The surface of the particles was covered by hydroxycarbonate-apatite (HCA) after five days in simulated body fluid (SBF). The antibacterial activity against Staphylococcus aureus was higher for the sol-gel-derived powder, showing inhibition >99% of the bacteria growth in 24 h for all concentrations studied. These BG-based powders present a set of characteristics useful for the formulation of multifunctional composites for orthopedic applications.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Deutscher Akademischer AustauschdienstDepartment of Chemistry Federal University of São Carlos (UFSCar) Rod. Washington Luis km 235 CP 676, São CarlosSão Paulo State University (UNESP) Institute of Chemistry, Rua Prof. Francisco Degni 55Institute of Biomaterials Department of Materials Science and Engineering Friedrich-Alexander-Universität Erlangen-Nürnberg, Cauerstrasse 6São Paulo State University (UNESP) Institute of Chemistry, Rua Prof. Francisco Degni 55CAPES: 001FAPESP: 2013/07296-2FAPESP: 2013/07793-6FAPESP: 2019/19609-1CNPq: 309711/2019-3Deutscher Akademischer Austauschdienst: 57552395Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (UNESP)Friedrich-Alexander-Universität Erlangen-NürnbergNovak, SaraOrives, Juliane Resges [UNESP]Nalin, Marcelo [UNESP]Unalan, IremBoccaccini, Aldo R.Camargo, Emerson R. de2023-03-01T20:16:39Z2023-03-01T20:16:39Z2022-10-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article29982-29990http://dx.doi.org/10.1016/j.ceramint.2022.06.266Ceramics International, v. 48, n. 20, p. 29982-29990, 2022.0272-8842http://hdl.handle.net/11449/24042410.1016/j.ceramint.2022.06.2662-s2.0-85133714946Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCeramics Internationalinfo:eu-repo/semantics/openAccess2023-03-01T20:16:39Zoai:repositorio.unesp.br:11449/240424Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:02:56.408762Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity |
title |
Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity |
spellingShingle |
Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity Novak, Sara Antimicrobial glass Bioactive glass-ceramic particles Ion release Mineralization |
title_short |
Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity |
title_full |
Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity |
title_fullStr |
Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity |
title_full_unstemmed |
Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity |
title_sort |
Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity |
author |
Novak, Sara |
author_facet |
Novak, Sara Orives, Juliane Resges [UNESP] Nalin, Marcelo [UNESP] Unalan, Irem Boccaccini, Aldo R. Camargo, Emerson R. de |
author_role |
author |
author2 |
Orives, Juliane Resges [UNESP] Nalin, Marcelo [UNESP] Unalan, Irem Boccaccini, Aldo R. Camargo, Emerson R. de |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (UNESP) Friedrich-Alexander-Universität Erlangen-Nürnberg |
dc.contributor.author.fl_str_mv |
Novak, Sara Orives, Juliane Resges [UNESP] Nalin, Marcelo [UNESP] Unalan, Irem Boccaccini, Aldo R. Camargo, Emerson R. de |
dc.subject.por.fl_str_mv |
Antimicrobial glass Bioactive glass-ceramic particles Ion release Mineralization |
topic |
Antimicrobial glass Bioactive glass-ceramic particles Ion release Mineralization |
description |
The biomedical engineering advances in the last years have been rising demand for multifunctional biomaterials. Bioactive glass (BG) submicron particles are potential candidates for the formulation of composites with improved dispersion and homogeneity between the constituents. This work presents the preparation of SiO2–Na2O–CaO–P2O5 glass-derived powders composed of particles with homogenous shapes and sizes between 300 and 500 nm. Two types of synthesis were employed for the preparation of the BG powders, the melt-quenching method, and a citric acid-assisted sol-gel route at a low citric acid concentration (0.005 mol L−1). The morphology of the particles was achieved by a low-energy process using a ball mill. These powders were characterized for their structure and surface area and evaluated for in vitro mineralization and antibacterial behavior. X-ray diffraction (XRD) analysis revealed different crystalline silicate phases in the sol-gel-derived powder and confirmed the amorphous structure of the melt-quenching-derived one. The surface of the particles was covered by hydroxycarbonate-apatite (HCA) after five days in simulated body fluid (SBF). The antibacterial activity against Staphylococcus aureus was higher for the sol-gel-derived powder, showing inhibition >99% of the bacteria growth in 24 h for all concentrations studied. These BG-based powders present a set of characteristics useful for the formulation of multifunctional composites for orthopedic applications. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-10-15 2023-03-01T20:16:39Z 2023-03-01T20:16:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ceramint.2022.06.266 Ceramics International, v. 48, n. 20, p. 29982-29990, 2022. 0272-8842 http://hdl.handle.net/11449/240424 10.1016/j.ceramint.2022.06.266 2-s2.0-85133714946 |
url |
http://dx.doi.org/10.1016/j.ceramint.2022.06.266 http://hdl.handle.net/11449/240424 |
identifier_str_mv |
Ceramics International, v. 48, n. 20, p. 29982-29990, 2022. 0272-8842 10.1016/j.ceramint.2022.06.266 2-s2.0-85133714946 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ceramics International |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
29982-29990 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129576666136576 |