Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity

Detalhes bibliográficos
Autor(a) principal: Novak, Sara
Data de Publicação: 2022
Outros Autores: Orives, Juliane Resges [UNESP], Nalin, Marcelo [UNESP], Unalan, Irem, Boccaccini, Aldo R., Camargo, Emerson R. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.ceramint.2022.06.266
http://hdl.handle.net/11449/240424
Resumo: The biomedical engineering advances in the last years have been rising demand for multifunctional biomaterials. Bioactive glass (BG) submicron particles are potential candidates for the formulation of composites with improved dispersion and homogeneity between the constituents. This work presents the preparation of SiO2–Na2O–CaO–P2O5 glass-derived powders composed of particles with homogenous shapes and sizes between 300 and 500 nm. Two types of synthesis were employed for the preparation of the BG powders, the melt-quenching method, and a citric acid-assisted sol-gel route at a low citric acid concentration (0.005 mol L−1). The morphology of the particles was achieved by a low-energy process using a ball mill. These powders were characterized for their structure and surface area and evaluated for in vitro mineralization and antibacterial behavior. X-ray diffraction (XRD) analysis revealed different crystalline silicate phases in the sol-gel-derived powder and confirmed the amorphous structure of the melt-quenching-derived one. The surface of the particles was covered by hydroxycarbonate-apatite (HCA) after five days in simulated body fluid (SBF). The antibacterial activity against Staphylococcus aureus was higher for the sol-gel-derived powder, showing inhibition >99% of the bacteria growth in 24 h for all concentrations studied. These BG-based powders present a set of characteristics useful for the formulation of multifunctional composites for orthopedic applications.
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spelling Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activityAntimicrobial glassBioactive glass-ceramic particlesIon releaseMineralizationThe biomedical engineering advances in the last years have been rising demand for multifunctional biomaterials. Bioactive glass (BG) submicron particles are potential candidates for the formulation of composites with improved dispersion and homogeneity between the constituents. This work presents the preparation of SiO2–Na2O–CaO–P2O5 glass-derived powders composed of particles with homogenous shapes and sizes between 300 and 500 nm. Two types of synthesis were employed for the preparation of the BG powders, the melt-quenching method, and a citric acid-assisted sol-gel route at a low citric acid concentration (0.005 mol L−1). The morphology of the particles was achieved by a low-energy process using a ball mill. These powders were characterized for their structure and surface area and evaluated for in vitro mineralization and antibacterial behavior. X-ray diffraction (XRD) analysis revealed different crystalline silicate phases in the sol-gel-derived powder and confirmed the amorphous structure of the melt-quenching-derived one. The surface of the particles was covered by hydroxycarbonate-apatite (HCA) after five days in simulated body fluid (SBF). The antibacterial activity against Staphylococcus aureus was higher for the sol-gel-derived powder, showing inhibition >99% of the bacteria growth in 24 h for all concentrations studied. These BG-based powders present a set of characteristics useful for the formulation of multifunctional composites for orthopedic applications.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Deutscher Akademischer AustauschdienstDepartment of Chemistry Federal University of São Carlos (UFSCar) Rod. Washington Luis km 235 CP 676, São CarlosSão Paulo State University (UNESP) Institute of Chemistry, Rua Prof. Francisco Degni 55Institute of Biomaterials Department of Materials Science and Engineering Friedrich-Alexander-Universität Erlangen-Nürnberg, Cauerstrasse 6São Paulo State University (UNESP) Institute of Chemistry, Rua Prof. Francisco Degni 55CAPES: 001FAPESP: 2013/07296-2FAPESP: 2013/07793-6FAPESP: 2019/19609-1CNPq: 309711/2019-3Deutscher Akademischer Austauschdienst: 57552395Universidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (UNESP)Friedrich-Alexander-Universität Erlangen-NürnbergNovak, SaraOrives, Juliane Resges [UNESP]Nalin, Marcelo [UNESP]Unalan, IremBoccaccini, Aldo R.Camargo, Emerson R. de2023-03-01T20:16:39Z2023-03-01T20:16:39Z2022-10-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article29982-29990http://dx.doi.org/10.1016/j.ceramint.2022.06.266Ceramics International, v. 48, n. 20, p. 29982-29990, 2022.0272-8842http://hdl.handle.net/11449/24042410.1016/j.ceramint.2022.06.2662-s2.0-85133714946Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengCeramics Internationalinfo:eu-repo/semantics/openAccess2023-03-01T20:16:39Zoai:repositorio.unesp.br:11449/240424Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-06T00:02:56.408762Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity
title Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity
spellingShingle Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity
Novak, Sara
Antimicrobial glass
Bioactive glass-ceramic particles
Ion release
Mineralization
title_short Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity
title_full Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity
title_fullStr Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity
title_full_unstemmed Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity
title_sort Quaternary bioactive glass-derived powders presenting submicrometric particles and antimicrobial activity
author Novak, Sara
author_facet Novak, Sara
Orives, Juliane Resges [UNESP]
Nalin, Marcelo [UNESP]
Unalan, Irem
Boccaccini, Aldo R.
Camargo, Emerson R. de
author_role author
author2 Orives, Juliane Resges [UNESP]
Nalin, Marcelo [UNESP]
Unalan, Irem
Boccaccini, Aldo R.
Camargo, Emerson R. de
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Carlos (UFSCar)
Universidade Estadual Paulista (UNESP)
Friedrich-Alexander-Universität Erlangen-Nürnberg
dc.contributor.author.fl_str_mv Novak, Sara
Orives, Juliane Resges [UNESP]
Nalin, Marcelo [UNESP]
Unalan, Irem
Boccaccini, Aldo R.
Camargo, Emerson R. de
dc.subject.por.fl_str_mv Antimicrobial glass
Bioactive glass-ceramic particles
Ion release
Mineralization
topic Antimicrobial glass
Bioactive glass-ceramic particles
Ion release
Mineralization
description The biomedical engineering advances in the last years have been rising demand for multifunctional biomaterials. Bioactive glass (BG) submicron particles are potential candidates for the formulation of composites with improved dispersion and homogeneity between the constituents. This work presents the preparation of SiO2–Na2O–CaO–P2O5 glass-derived powders composed of particles with homogenous shapes and sizes between 300 and 500 nm. Two types of synthesis were employed for the preparation of the BG powders, the melt-quenching method, and a citric acid-assisted sol-gel route at a low citric acid concentration (0.005 mol L−1). The morphology of the particles was achieved by a low-energy process using a ball mill. These powders were characterized for their structure and surface area and evaluated for in vitro mineralization and antibacterial behavior. X-ray diffraction (XRD) analysis revealed different crystalline silicate phases in the sol-gel-derived powder and confirmed the amorphous structure of the melt-quenching-derived one. The surface of the particles was covered by hydroxycarbonate-apatite (HCA) after five days in simulated body fluid (SBF). The antibacterial activity against Staphylococcus aureus was higher for the sol-gel-derived powder, showing inhibition >99% of the bacteria growth in 24 h for all concentrations studied. These BG-based powders present a set of characteristics useful for the formulation of multifunctional composites for orthopedic applications.
publishDate 2022
dc.date.none.fl_str_mv 2022-10-15
2023-03-01T20:16:39Z
2023-03-01T20:16:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.ceramint.2022.06.266
Ceramics International, v. 48, n. 20, p. 29982-29990, 2022.
0272-8842
http://hdl.handle.net/11449/240424
10.1016/j.ceramint.2022.06.266
2-s2.0-85133714946
url http://dx.doi.org/10.1016/j.ceramint.2022.06.266
http://hdl.handle.net/11449/240424
identifier_str_mv Ceramics International, v. 48, n. 20, p. 29982-29990, 2022.
0272-8842
10.1016/j.ceramint.2022.06.266
2-s2.0-85133714946
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ceramics International
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 29982-29990
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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