Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
DOI: | 10.1111/1346-8138.16101 |
Texto Completo: | http://dx.doi.org/10.1111/1346-8138.16101 http://hdl.handle.net/11449/231496 |
Resumo: | Chromoblastomycosis (CBM) is an infectious disease caused by fungi that is prevalent in tropical and subtropical countries. Besides few therapeutic options, the classical treatment of CBM needs to be administrated for a long period of time, and unfortunately some patients do not show improvement of the lesions. Thus, it becomes urgent to develop new strategies for the treatment of CBM. This work reports a successful treatment, performed with the combination of oral acitretin (50 mg/kg, once a day) plus topical imiquimod (50 mg/g, five times per week) for 5 months in a patient with CBM. A significant improvement of the lesions was observed in the 1st month, and in the 5th a complete regression of lesions was recorded. Changes in the biochemical parameters were not observed. These data suggest that the combination of acitretin and imiquimod may be effective at treating CBM. |
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Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment timeacitretinchromoblastomycosisimiquimodlesion evolutiontreatmentChromoblastomycosis (CBM) is an infectious disease caused by fungi that is prevalent in tropical and subtropical countries. Besides few therapeutic options, the classical treatment of CBM needs to be administrated for a long period of time, and unfortunately some patients do not show improvement of the lesions. Thus, it becomes urgent to develop new strategies for the treatment of CBM. This work reports a successful treatment, performed with the combination of oral acitretin (50 mg/kg, once a day) plus topical imiquimod (50 mg/g, five times per week) for 5 months in a patient with CBM. A significant improvement of the lesions was observed in the 1st month, and in the 5th a complete regression of lesions was recorded. Changes in the biochemical parameters were not observed. These data suggest that the combination of acitretin and imiquimod may be effective at treating CBM.Dermatology Department Medical School Clinics Hospital University of São PauloLaboratory of Pathology of Infectious Diseases Medical School University of São PauloDermatology Division Medical School Clinics Hospital University of São PauloSão Paulo State University (UNESP) Institute of BiosciencesSão Paulo State University (UNESP) Institute for Advanced Studies of OceanSão Paulo State University (UNESP) Institute of BiosciencesSão Paulo State University (UNESP) Institute for Advanced Studies of OceanUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Belda, WalterCasolato, Ana Thereza StradiotoLuppi, Juliana BronzatoPassero, Luiz Felipe Domingues [UNESP]2022-04-29T08:45:40Z2022-04-29T08:45:40Z2021-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1612-1615http://dx.doi.org/10.1111/1346-8138.16101Journal of Dermatology, v. 48, n. 10, p. 1612-1615, 2021.1346-81380385-2407http://hdl.handle.net/11449/23149610.1111/1346-8138.161012-s2.0-85112861437Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Dermatologyinfo:eu-repo/semantics/openAccess2024-09-03T13:15:05Zoai:repositorio.unesp.br:11449/231496Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time |
title |
Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time |
spellingShingle |
Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time Belda, Walter acitretin chromoblastomycosis imiquimod lesion evolution treatment Belda, Walter acitretin chromoblastomycosis imiquimod lesion evolution treatment |
title_short |
Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time |
title_full |
Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time |
title_fullStr |
Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time |
title_full_unstemmed |
Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time |
title_sort |
Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time |
author |
Belda, Walter |
author_facet |
Belda, Walter Belda, Walter Casolato, Ana Thereza Stradioto Luppi, Juliana Bronzato Passero, Luiz Felipe Domingues [UNESP] Casolato, Ana Thereza Stradioto Luppi, Juliana Bronzato Passero, Luiz Felipe Domingues [UNESP] |
author_role |
author |
author2 |
Casolato, Ana Thereza Stradioto Luppi, Juliana Bronzato Passero, Luiz Felipe Domingues [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Belda, Walter Casolato, Ana Thereza Stradioto Luppi, Juliana Bronzato Passero, Luiz Felipe Domingues [UNESP] |
dc.subject.por.fl_str_mv |
acitretin chromoblastomycosis imiquimod lesion evolution treatment |
topic |
acitretin chromoblastomycosis imiquimod lesion evolution treatment |
description |
Chromoblastomycosis (CBM) is an infectious disease caused by fungi that is prevalent in tropical and subtropical countries. Besides few therapeutic options, the classical treatment of CBM needs to be administrated for a long period of time, and unfortunately some patients do not show improvement of the lesions. Thus, it becomes urgent to develop new strategies for the treatment of CBM. This work reports a successful treatment, performed with the combination of oral acitretin (50 mg/kg, once a day) plus topical imiquimod (50 mg/g, five times per week) for 5 months in a patient with CBM. A significant improvement of the lesions was observed in the 1st month, and in the 5th a complete regression of lesions was recorded. Changes in the biochemical parameters were not observed. These data suggest that the combination of acitretin and imiquimod may be effective at treating CBM. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-01 2022-04-29T08:45:40Z 2022-04-29T08:45:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/1346-8138.16101 Journal of Dermatology, v. 48, n. 10, p. 1612-1615, 2021. 1346-8138 0385-2407 http://hdl.handle.net/11449/231496 10.1111/1346-8138.16101 2-s2.0-85112861437 |
url |
http://dx.doi.org/10.1111/1346-8138.16101 http://hdl.handle.net/11449/231496 |
identifier_str_mv |
Journal of Dermatology, v. 48, n. 10, p. 1612-1615, 2021. 1346-8138 0385-2407 10.1111/1346-8138.16101 2-s2.0-85112861437 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Dermatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1612-1615 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1822183589774622720 |
dc.identifier.doi.none.fl_str_mv |
10.1111/1346-8138.16101 |