Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans

Detalhes bibliográficos
Autor(a) principal: Biagioni, Maria Fernanda G [UNESP]
Data de Publicação: 2017
Outros Autores: Mendes, Adriana L [UNESP], Nogueira, Célia Regina [UNESP], Leite, Celso V [UNESP], Gollino, Loraine [UNESP], Mazeto, Gláucia Mfs [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s11695-017-2546-4
http://hdl.handle.net/11449/174133
Resumo: Purpose: Bariatric surgery has been associated with bone remodeling changes. The action of adipokines on the expression of receptor activator of nuclear factor kappa β ligand (RANKL) and osteoprotegerin (OPG) and on an increase in sclerostin could be related to these changes. Materials and Methods: This study aimed to assess the repercussions of weight loss, fat mass (FM), and fat-free mass (FFM) loss and biochemical and hormonal changes on bone remodeling markers after Roux-en-Y gastric bypass (RYGB). Anthropometric data, parathyroid hormone (PTH), bone-specific alkaline phosphatase (BSAP), collagen type 1 C-telopeptide (CTX), 25-hydroxy vitamin D (25-OH-VitD), leptin, adiponectin, RANKL, OPG, and sclerostin of 30 menstruating women were measured preoperatively (Pre), and 3, 12, and 24 months (m) after RYGB. Results: Leptin (34.4 (14.7; 51.9) vs. 22.5 (1.9; 52.7) ng/mL) and OPG (3.6 (1.1; 11.5) vs. 3.4 (1.5; 6) pmol/L) decreased, and adiponectin (7.4 (1.7; 18.4) vs. 13.8 (3.0; 34.6) μg/mL), CTX (0.2 (0.1; 2.2) vs. 0.6 (0.4; 6.0) ng/mL), RANKL (0.1 (0.0; 0.5) vs. 0.3 (0.0; 2.0) pmol/L), and sclerostin (21.7 (3.2; 75.1) vs. 34.8 (6.4; 80.5) pmol/L) increased after 3 m. BSAP increased after 12 m (10.1 (5.4; 18.9) vs. 13.9 (6.9; 30.2) μg/mL) (p < 0.005). CTX correlated positively with adiponectin at 24 m and inversely with leptin Pre; OPG at 3 m; weight, FM, FFM, and leptin at 24 m. RANKL correlated directly with weight at 3 m. Sclerostin correlated inversely with weight Pre and FM at 3 m. BSAP correlated negatively with 25-OH-VitD at 12 m, and positively with PTH at 24 m. Conclusions: RYGB induced weight loss, and biochemical, hormonal, and body composition changes are associated with higher bone remodeling.
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spelling Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in HumansBariatric surgeryBiomarkersBone remodelingCytokinesWnt/β-catenin/LRPsPurpose: Bariatric surgery has been associated with bone remodeling changes. The action of adipokines on the expression of receptor activator of nuclear factor kappa β ligand (RANKL) and osteoprotegerin (OPG) and on an increase in sclerostin could be related to these changes. Materials and Methods: This study aimed to assess the repercussions of weight loss, fat mass (FM), and fat-free mass (FFM) loss and biochemical and hormonal changes on bone remodeling markers after Roux-en-Y gastric bypass (RYGB). Anthropometric data, parathyroid hormone (PTH), bone-specific alkaline phosphatase (BSAP), collagen type 1 C-telopeptide (CTX), 25-hydroxy vitamin D (25-OH-VitD), leptin, adiponectin, RANKL, OPG, and sclerostin of 30 menstruating women were measured preoperatively (Pre), and 3, 12, and 24 months (m) after RYGB. Results: Leptin (34.4 (14.7; 51.9) vs. 22.5 (1.9; 52.7) ng/mL) and OPG (3.6 (1.1; 11.5) vs. 3.4 (1.5; 6) pmol/L) decreased, and adiponectin (7.4 (1.7; 18.4) vs. 13.8 (3.0; 34.6) μg/mL), CTX (0.2 (0.1; 2.2) vs. 0.6 (0.4; 6.0) ng/mL), RANKL (0.1 (0.0; 0.5) vs. 0.3 (0.0; 2.0) pmol/L), and sclerostin (21.7 (3.2; 75.1) vs. 34.8 (6.4; 80.5) pmol/L) increased after 3 m. BSAP increased after 12 m (10.1 (5.4; 18.9) vs. 13.9 (6.9; 30.2) μg/mL) (p < 0.005). CTX correlated positively with adiponectin at 24 m and inversely with leptin Pre; OPG at 3 m; weight, FM, FFM, and leptin at 24 m. RANKL correlated directly with weight at 3 m. Sclerostin correlated inversely with weight Pre and FM at 3 m. BSAP correlated negatively with 25-OH-VitD at 12 m, and positively with PTH at 24 m. Conclusions: RYGB induced weight loss, and biochemical, hormonal, and body composition changes are associated with higher bone remodeling.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Internal Medicine Department (MFGB ALM CRN LG GMFSM) Botucatu Medical School São Paulo State University FMB-UnespInternal Medicine Department Botucatu Medical School São Paulo State University FMB-Unesp, Rubião Júnior District, no numberSurgery Department (CVL) Botucatu Medical School São Paulo State University FMB-UnespInternal Medicine Department (MFGB ALM CRN LG GMFSM) Botucatu Medical School São Paulo State University FMB-UnespInternal Medicine Department Botucatu Medical School São Paulo State University FMB-Unesp, Rubião Júnior District, no numberSurgery Department (CVL) Botucatu Medical School São Paulo State University FMB-UnespFAPESP: 2009/50169-6Universidade Estadual Paulista (Unesp)Biagioni, Maria Fernanda G [UNESP]Mendes, Adriana L [UNESP]Nogueira, Célia Regina [UNESP]Leite, Celso V [UNESP]Gollino, Loraine [UNESP]Mazeto, Gláucia Mfs [UNESP]2018-12-11T17:09:29Z2018-12-11T17:09:29Z2017-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1789-1796application/pdfhttp://dx.doi.org/10.1007/s11695-017-2546-4Obesity Surgery, v. 27, n. 7, p. 1789-1796, 2017.1708-04280960-8923http://hdl.handle.net/11449/17413310.1007/s11695-017-2546-42-s2.0-850107643792-s2.0-85010764379.pdf436999601719076731918944521357770000-0002-6716-1170Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengObesity Surgery1,396info:eu-repo/semantics/openAccess2024-08-14T17:36:30Zoai:repositorio.unesp.br:11449/174133Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:36:30Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans
title Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans
spellingShingle Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans
Biagioni, Maria Fernanda G [UNESP]
Bariatric surgery
Biomarkers
Bone remodeling
Cytokines
Wnt/β-catenin/LRPs
title_short Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans
title_full Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans
title_fullStr Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans
title_full_unstemmed Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans
title_sort Bariatric Roux-En-Y Gastric Bypass Surgery: Adipocyte Proteins Involved in Increased Bone Remodeling in Humans
author Biagioni, Maria Fernanda G [UNESP]
author_facet Biagioni, Maria Fernanda G [UNESP]
Mendes, Adriana L [UNESP]
Nogueira, Célia Regina [UNESP]
Leite, Celso V [UNESP]
Gollino, Loraine [UNESP]
Mazeto, Gláucia Mfs [UNESP]
author_role author
author2 Mendes, Adriana L [UNESP]
Nogueira, Célia Regina [UNESP]
Leite, Celso V [UNESP]
Gollino, Loraine [UNESP]
Mazeto, Gláucia Mfs [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Biagioni, Maria Fernanda G [UNESP]
Mendes, Adriana L [UNESP]
Nogueira, Célia Regina [UNESP]
Leite, Celso V [UNESP]
Gollino, Loraine [UNESP]
Mazeto, Gláucia Mfs [UNESP]
dc.subject.por.fl_str_mv Bariatric surgery
Biomarkers
Bone remodeling
Cytokines
Wnt/β-catenin/LRPs
topic Bariatric surgery
Biomarkers
Bone remodeling
Cytokines
Wnt/β-catenin/LRPs
description Purpose: Bariatric surgery has been associated with bone remodeling changes. The action of adipokines on the expression of receptor activator of nuclear factor kappa β ligand (RANKL) and osteoprotegerin (OPG) and on an increase in sclerostin could be related to these changes. Materials and Methods: This study aimed to assess the repercussions of weight loss, fat mass (FM), and fat-free mass (FFM) loss and biochemical and hormonal changes on bone remodeling markers after Roux-en-Y gastric bypass (RYGB). Anthropometric data, parathyroid hormone (PTH), bone-specific alkaline phosphatase (BSAP), collagen type 1 C-telopeptide (CTX), 25-hydroxy vitamin D (25-OH-VitD), leptin, adiponectin, RANKL, OPG, and sclerostin of 30 menstruating women were measured preoperatively (Pre), and 3, 12, and 24 months (m) after RYGB. Results: Leptin (34.4 (14.7; 51.9) vs. 22.5 (1.9; 52.7) ng/mL) and OPG (3.6 (1.1; 11.5) vs. 3.4 (1.5; 6) pmol/L) decreased, and adiponectin (7.4 (1.7; 18.4) vs. 13.8 (3.0; 34.6) μg/mL), CTX (0.2 (0.1; 2.2) vs. 0.6 (0.4; 6.0) ng/mL), RANKL (0.1 (0.0; 0.5) vs. 0.3 (0.0; 2.0) pmol/L), and sclerostin (21.7 (3.2; 75.1) vs. 34.8 (6.4; 80.5) pmol/L) increased after 3 m. BSAP increased after 12 m (10.1 (5.4; 18.9) vs. 13.9 (6.9; 30.2) μg/mL) (p < 0.005). CTX correlated positively with adiponectin at 24 m and inversely with leptin Pre; OPG at 3 m; weight, FM, FFM, and leptin at 24 m. RANKL correlated directly with weight at 3 m. Sclerostin correlated inversely with weight Pre and FM at 3 m. BSAP correlated negatively with 25-OH-VitD at 12 m, and positively with PTH at 24 m. Conclusions: RYGB induced weight loss, and biochemical, hormonal, and body composition changes are associated with higher bone remodeling.
publishDate 2017
dc.date.none.fl_str_mv 2017-07-01
2018-12-11T17:09:29Z
2018-12-11T17:09:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s11695-017-2546-4
Obesity Surgery, v. 27, n. 7, p. 1789-1796, 2017.
1708-0428
0960-8923
http://hdl.handle.net/11449/174133
10.1007/s11695-017-2546-4
2-s2.0-85010764379
2-s2.0-85010764379.pdf
4369996017190767
3191894452135777
0000-0002-6716-1170
url http://dx.doi.org/10.1007/s11695-017-2546-4
http://hdl.handle.net/11449/174133
identifier_str_mv Obesity Surgery, v. 27, n. 7, p. 1789-1796, 2017.
1708-0428
0960-8923
10.1007/s11695-017-2546-4
2-s2.0-85010764379
2-s2.0-85010764379.pdf
4369996017190767
3191894452135777
0000-0002-6716-1170
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Obesity Surgery
1,396
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1789-1796
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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