Effects of ZnO/TiO2 nanoparticle and TiO2 nanotube additions to dense polycrystalline hydroxyapatite bioceramic from bovine bones

• Autor(a) principal: Pires, Luara Aline
• Data de Publicação: 2020
• Outros Autores: Azevedo Silva, Lucas Jose de, Ferrairo, Brunna Mota, Erbereli, Rogerio, Parreira Lovo, Joao Fiore, Gomes, Orisson Ponce [UNESP], Rubo, Jose Henrique, Lisboa-Filho, Paulo Noronha [UNESP], Griggs, Jason Alan, Fortulan, Carlos Alberto, Sanches Borges, Ana Flavia
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1016/j.dental.2019.11.006; http://hdl.handle.net/11449/196513
• topic: Ceramics; Durapatite; Nanop articles; Nanotubes

Objectives. A bovine dense hydroxyapatite ceramic (HA) was produced as new biomaterial, however, the production of a material with consistently high flexural strength remains challenging. The objective of this study was to evaluate the effects of ZnO nanoparticles, TiO2 nanoparticles, and TiO2 nanotubes (1%, 2%, and 5% by weight) on the microstructure and flexural strength of a bovine dense hydroxyapatite ceramic (HA). Methods. Discs ((sic) =12.5 mm; thickness =1.3 mm) were prepared and subjected to X-ray diffraction (XRD), and observation with a field emission scanning electron microscope (FE-SEM), biaxial flexural strength (BFS) testing, and Vickers hardness (VH) testing. The BFS and VH data were subjected to ANOVA and Tukey post-hoc tests (alpha = 0.05) and Weibull analysis. Results. The XRD showed that the addition of nanomaterials caused the formation of a secondary phase when 5% of the ZnO nanoparticles was used, or when all percentages of the TiO2 nanoparticles/nanotubes were used, and the HA crystallographic planes were maintained. Differences were not observed between the higher BFS values obtained with pure HA and those obtained with the 5% addition of TiO2 nanoparticles. However, the results were different compared with the other groups (alpha = 0.05). The results obtained by Weibull analysis revealed that the 1%, 2%, and 5% addition of TiO2 nanotubes, and the 1% and 2% addition of TiO2 nanoparticles decreased the HA characteristic strength (sigma(0)), while the Weibull modulus (m) increased when 5% of TiO2 nanoparticles, 1% and 2% of ZnO nanoparticles, and 2% of TiO2 nanoparticles were added, but with no statistical difference from the pure HA. The 5% addition of ZnO2 nanoparticles decreased the sigma(0) without changing m. Moreover, the 5% addition of TiO2 nanoparticles resulted in an m closest to that of pure HA. Regarding the VH results, the blend of HA with 1% and 2% addition of TiO2 nanoparticles exhibited the higher values, which were similar between the different addition ratios (p = 0.102). Moreover, the addition of 5% TiO2 nanoparticles resulted in higher value compared with pure HA. Significance. This study demonstrated that the HA blend with 5% of TiO2 nanoparticles has the greatest potential as a bovine HA dense bioceramic reinforcement. (C) 2019 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved.