Morfina nasal: Avaliacao da analgesia e dos efeitos colaterais no tratamento da dor pos-operatoria em criancas
Autor(a) principal: | |
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Data de Publicação: | 2000 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.sba.com.br/arquivos/revista/rba/mar00112.pdf http://hdl.handle.net/11449/66074 |
Resumo: | Background and Objectives - Postoperative pain is one of the major discomforts but often under treated, especially in the pediatric patient. The aim of this study was to evaluate nasal morphine postoperative analgesia as an alternative drug administration route and show its applicability, effectiveness, tolerability and side effects. Methods - Participated in this study 20 patients aged 3 to 13 years, physical status ASA I and II sequentially submitted the different small and medium-size surgeries. Analgesia was obtained with nasal morphine hydrochloride in aqueous solution in variable concentrations of 2%, 1%, 0.5%, 0.25% and 0.125%. The dose for each instillation has been 0.1 mg.kg -1 at three-hour intervals for 36 postoperative hours. Quality of analgesia in pre-verbal age patients was evaluated by a pain intensity scale based on facial expression and crying, sleep, motor activity, sociability and food ingestion was used. Standardized evaluations were performed at 3-hour intervals. A four-grade scale was used to evaluate tolerability, where: 1) Good; 2) Regular; 3) Bad; 4) Very bad. Result - Postoperative analgesia results have proven to be good and safe, especially from the third evaluation on (6 hours). Drug tolerability has been good, although side effects were observed, especially nausea and vomiting. Conclusions - Patients and relatives accepted the method very well. The nasal route was considered an adequate way for opioid administration although more studies are needed to accept it as a routine for postoperative morphine analgesia. |
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Morfina nasal: Avaliacao da analgesia e dos efeitos colaterais no tratamento da dor pos-operatoria em criancasNasal morphine: Evaluation of analgesia and side-effects in the treatment of pediatric postoperative painAnalgesia: PostoperativeAnalgesics, opioids: Morphinemorphineadolescentchildclinical articledrug efficacydrug safetydrug tolerabilityfemalehumanmalepain assessmentpediatric anesthesiapostoperative analgesiapostoperative nauseapostoperative painvomitingBackground and Objectives - Postoperative pain is one of the major discomforts but often under treated, especially in the pediatric patient. The aim of this study was to evaluate nasal morphine postoperative analgesia as an alternative drug administration route and show its applicability, effectiveness, tolerability and side effects. Methods - Participated in this study 20 patients aged 3 to 13 years, physical status ASA I and II sequentially submitted the different small and medium-size surgeries. Analgesia was obtained with nasal morphine hydrochloride in aqueous solution in variable concentrations of 2%, 1%, 0.5%, 0.25% and 0.125%. The dose for each instillation has been 0.1 mg.kg -1 at three-hour intervals for 36 postoperative hours. Quality of analgesia in pre-verbal age patients was evaluated by a pain intensity scale based on facial expression and crying, sleep, motor activity, sociability and food ingestion was used. Standardized evaluations were performed at 3-hour intervals. A four-grade scale was used to evaluate tolerability, where: 1) Good; 2) Regular; 3) Bad; 4) Very bad. Result - Postoperative analgesia results have proven to be good and safe, especially from the third evaluation on (6 hours). Drug tolerability has been good, although side effects were observed, especially nausea and vomiting. Conclusions - Patients and relatives accepted the method very well. The nasal route was considered an adequate way for opioid administration although more studies are needed to accept it as a routine for postoperative morphine analgesia.Depto. Anestesiologia FMB - UNESP, Distrito de Rublao Junior, 18618-970 Botucatu, SPDepto. Anestesiologia FMB - UNESP, Distrito de Rublao Junior, 18618-970 Botucatu, SPUniversidade Estadual Paulista (Unesp)Lemonica, L. [UNESP]Pereira, S. M. [UNESP]D'Antonio, M. C. [UNESP]Richetti, S. M R [UNESP]Morato, A. L A [UNESP]2014-05-27T11:19:52Z2014-05-27T11:19:52Z2000-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article112-117application/pdfhttp://www.sba.com.br/arquivos/revista/rba/mar00112.pdfRevista Brasileira de Anestesiologia, v. 50, n. 2, p. 112-117, 2000.0034-7094http://hdl.handle.net/11449/660742-s2.0-00340669942-s2.0-0034066994.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista Brasileira de Anestesiologia0.8500,320info:eu-repo/semantics/openAccess2023-10-15T06:05:46Zoai:repositorio.unesp.br:11449/66074Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-15T06:05:46Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Morfina nasal: Avaliacao da analgesia e dos efeitos colaterais no tratamento da dor pos-operatoria em criancas Nasal morphine: Evaluation of analgesia and side-effects in the treatment of pediatric postoperative pain |
title |
Morfina nasal: Avaliacao da analgesia e dos efeitos colaterais no tratamento da dor pos-operatoria em criancas |
spellingShingle |
Morfina nasal: Avaliacao da analgesia e dos efeitos colaterais no tratamento da dor pos-operatoria em criancas Lemonica, L. [UNESP] Analgesia: Postoperative Analgesics, opioids: Morphine morphine adolescent child clinical article drug efficacy drug safety drug tolerability female human male pain assessment pediatric anesthesia postoperative analgesia postoperative nausea postoperative pain vomiting |
title_short |
Morfina nasal: Avaliacao da analgesia e dos efeitos colaterais no tratamento da dor pos-operatoria em criancas |
title_full |
Morfina nasal: Avaliacao da analgesia e dos efeitos colaterais no tratamento da dor pos-operatoria em criancas |
title_fullStr |
Morfina nasal: Avaliacao da analgesia e dos efeitos colaterais no tratamento da dor pos-operatoria em criancas |
title_full_unstemmed |
Morfina nasal: Avaliacao da analgesia e dos efeitos colaterais no tratamento da dor pos-operatoria em criancas |
title_sort |
Morfina nasal: Avaliacao da analgesia e dos efeitos colaterais no tratamento da dor pos-operatoria em criancas |
author |
Lemonica, L. [UNESP] |
author_facet |
Lemonica, L. [UNESP] Pereira, S. M. [UNESP] D'Antonio, M. C. [UNESP] Richetti, S. M R [UNESP] Morato, A. L A [UNESP] |
author_role |
author |
author2 |
Pereira, S. M. [UNESP] D'Antonio, M. C. [UNESP] Richetti, S. M R [UNESP] Morato, A. L A [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Lemonica, L. [UNESP] Pereira, S. M. [UNESP] D'Antonio, M. C. [UNESP] Richetti, S. M R [UNESP] Morato, A. L A [UNESP] |
dc.subject.por.fl_str_mv |
Analgesia: Postoperative Analgesics, opioids: Morphine morphine adolescent child clinical article drug efficacy drug safety drug tolerability female human male pain assessment pediatric anesthesia postoperative analgesia postoperative nausea postoperative pain vomiting |
topic |
Analgesia: Postoperative Analgesics, opioids: Morphine morphine adolescent child clinical article drug efficacy drug safety drug tolerability female human male pain assessment pediatric anesthesia postoperative analgesia postoperative nausea postoperative pain vomiting |
description |
Background and Objectives - Postoperative pain is one of the major discomforts but often under treated, especially in the pediatric patient. The aim of this study was to evaluate nasal morphine postoperative analgesia as an alternative drug administration route and show its applicability, effectiveness, tolerability and side effects. Methods - Participated in this study 20 patients aged 3 to 13 years, physical status ASA I and II sequentially submitted the different small and medium-size surgeries. Analgesia was obtained with nasal morphine hydrochloride in aqueous solution in variable concentrations of 2%, 1%, 0.5%, 0.25% and 0.125%. The dose for each instillation has been 0.1 mg.kg -1 at three-hour intervals for 36 postoperative hours. Quality of analgesia in pre-verbal age patients was evaluated by a pain intensity scale based on facial expression and crying, sleep, motor activity, sociability and food ingestion was used. Standardized evaluations were performed at 3-hour intervals. A four-grade scale was used to evaluate tolerability, where: 1) Good; 2) Regular; 3) Bad; 4) Very bad. Result - Postoperative analgesia results have proven to be good and safe, especially from the third evaluation on (6 hours). Drug tolerability has been good, although side effects were observed, especially nausea and vomiting. Conclusions - Patients and relatives accepted the method very well. The nasal route was considered an adequate way for opioid administration although more studies are needed to accept it as a routine for postoperative morphine analgesia. |
publishDate |
2000 |
dc.date.none.fl_str_mv |
2000-01-01 2014-05-27T11:19:52Z 2014-05-27T11:19:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.sba.com.br/arquivos/revista/rba/mar00112.pdf Revista Brasileira de Anestesiologia, v. 50, n. 2, p. 112-117, 2000. 0034-7094 http://hdl.handle.net/11449/66074 2-s2.0-0034066994 2-s2.0-0034066994.pdf |
url |
http://www.sba.com.br/arquivos/revista/rba/mar00112.pdf http://hdl.handle.net/11449/66074 |
identifier_str_mv |
Revista Brasileira de Anestesiologia, v. 50, n. 2, p. 112-117, 2000. 0034-7094 2-s2.0-0034066994 2-s2.0-0034066994.pdf |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista Brasileira de Anestesiologia 0.850 0,320 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
112-117 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1803649420616531968 |