Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S1415-47572008000500012 http://hdl.handle.net/11449/225438 |
Resumo: | The growth hormone 1 gene (GH1) is a candidate gene for body weight and weight gain in cattle since it plays a fundamental role in growth regulation. We investigated the GH1gene AluI and DdeI restriction enzyme polymorphisms, located 149 bp apart in the cattle genome, as possible markers of the production potential of Canchim crossbreed cattle, a 5/8 Charolais (Bos taurus) and 3/8 Nelore (Bos indicus) breed developed in Brazil, by evaluating the birth weight, weaning weight, yearling weight and plasma insulin-like growth factor-1 (IGF-1) concentration of 7 month to 10 months old Canchim calves (n = 204) of known genealogy and which had been genotyped for the AluI and DdeI markers. Our results showed significant effect (p < 0.05) between the homozygous DdeI+/DdeI+ polymorphism and the estimated breeding value for weaning weight (ESB-WW), while the AluI leucine homozygous (L/L) and leucine/valine (L/ V) heterozygous polymorphisms showed no significant effect on the traits studied. The restriction sites of the two enzymes led to the formation of haplotypes which also exerted a significant effect (p < 0.05) on the ESB-WW, with the largest difference being 8.5 kg in favor of the homozygous L plus DdeI+/L plus DdeI+ genotype over the heterozygous L plus DdeI-/V plus DdeI+ genotype. Copyright © 2008, Sociedade Brasileira de Genética. |
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Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a modelBeef cattleCandidate geneGrowth hormonePolymorphismThe growth hormone 1 gene (GH1) is a candidate gene for body weight and weight gain in cattle since it plays a fundamental role in growth regulation. We investigated the GH1gene AluI and DdeI restriction enzyme polymorphisms, located 149 bp apart in the cattle genome, as possible markers of the production potential of Canchim crossbreed cattle, a 5/8 Charolais (Bos taurus) and 3/8 Nelore (Bos indicus) breed developed in Brazil, by evaluating the birth weight, weaning weight, yearling weight and plasma insulin-like growth factor-1 (IGF-1) concentration of 7 month to 10 months old Canchim calves (n = 204) of known genealogy and which had been genotyped for the AluI and DdeI markers. Our results showed significant effect (p < 0.05) between the homozygous DdeI+/DdeI+ polymorphism and the estimated breeding value for weaning weight (ESB-WW), while the AluI leucine homozygous (L/L) and leucine/valine (L/ V) heterozygous polymorphisms showed no significant effect on the traits studied. The restriction sites of the two enzymes led to the formation of haplotypes which also exerted a significant effect (p < 0.05) on the ESB-WW, with the largest difference being 8.5 kg in favor of the homozygous L plus DdeI+/L plus DdeI+ genotype over the heterozygous L plus DdeI-/V plus DdeI+ genotype. Copyright © 2008, Sociedade Brasileira de Genética.Departamento de Melhoramento e Nutrição Animal Faculdade de Medicina Veterinária e Zootecnia Universidade Estudual Paulista Júlio de Mesquita Filho, 18618-000 Botucatu, SPEmpresa Brasileira de Pesquisa Agropecuária Centro de Pesquisa de Pecuária do Sudeste, Fazenda Canchim São Carlos, SPDepartamento de Melhoramento e Nutrição Animal Faculdade de Medicina Veterinária e Zootecnia Universidade Estudual Paulista Júlio de Mesquita Filho, 18618-000 Botucatu, SPUniversidade Estadual Paulista (UNESP)Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA)Silveira, Luiz Guilherme G. [UNESP]Furlan, Luiz R. [UNESP]Curi, Rogério A. [UNESP]Ferraz, André Luiz J. [UNESP]de Alencar, Maurício M.Regitano, Luciana C.A.Martins, Cyntia L. [UNESP]de Beni Arrigoni, Mário [UNESP]Suguisawa, Liliane [UNESP]Silveira, Antônio C. [UNESP]de Oliveira, Henrique N. [UNESP]2022-04-28T20:50:24Z2022-04-28T20:50:24Z2008-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article874-879http://dx.doi.org/10.1590/S1415-47572008000500012Genetics and Molecular Biology, v. 31, n. 4, p. 874-879, 2008.1678-46851415-4757http://hdl.handle.net/11449/22543810.1590/S1415-475720080005000122-s2.0-62549119059Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengGenetics and Molecular Biologyinfo:eu-repo/semantics/openAccess2022-04-28T20:50:24Zoai:repositorio.unesp.br:11449/225438Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T20:50:24Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model |
title |
Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model |
spellingShingle |
Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model Silveira, Luiz Guilherme G. [UNESP] Beef cattle Candidate gene Growth hormone Polymorphism |
title_short |
Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model |
title_full |
Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model |
title_fullStr |
Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model |
title_full_unstemmed |
Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model |
title_sort |
Growth hormone 1 gene (GH1) polymorphisms as possible markers of the production potential of beef cattle using the Brazilian Canchim breed as a model |
author |
Silveira, Luiz Guilherme G. [UNESP] |
author_facet |
Silveira, Luiz Guilherme G. [UNESP] Furlan, Luiz R. [UNESP] Curi, Rogério A. [UNESP] Ferraz, André Luiz J. [UNESP] de Alencar, Maurício M. Regitano, Luciana C.A. Martins, Cyntia L. [UNESP] de Beni Arrigoni, Mário [UNESP] Suguisawa, Liliane [UNESP] Silveira, Antônio C. [UNESP] de Oliveira, Henrique N. [UNESP] |
author_role |
author |
author2 |
Furlan, Luiz R. [UNESP] Curi, Rogério A. [UNESP] Ferraz, André Luiz J. [UNESP] de Alencar, Maurício M. Regitano, Luciana C.A. Martins, Cyntia L. [UNESP] de Beni Arrigoni, Mário [UNESP] Suguisawa, Liliane [UNESP] Silveira, Antônio C. [UNESP] de Oliveira, Henrique N. [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA) |
dc.contributor.author.fl_str_mv |
Silveira, Luiz Guilherme G. [UNESP] Furlan, Luiz R. [UNESP] Curi, Rogério A. [UNESP] Ferraz, André Luiz J. [UNESP] de Alencar, Maurício M. Regitano, Luciana C.A. Martins, Cyntia L. [UNESP] de Beni Arrigoni, Mário [UNESP] Suguisawa, Liliane [UNESP] Silveira, Antônio C. [UNESP] de Oliveira, Henrique N. [UNESP] |
dc.subject.por.fl_str_mv |
Beef cattle Candidate gene Growth hormone Polymorphism |
topic |
Beef cattle Candidate gene Growth hormone Polymorphism |
description |
The growth hormone 1 gene (GH1) is a candidate gene for body weight and weight gain in cattle since it plays a fundamental role in growth regulation. We investigated the GH1gene AluI and DdeI restriction enzyme polymorphisms, located 149 bp apart in the cattle genome, as possible markers of the production potential of Canchim crossbreed cattle, a 5/8 Charolais (Bos taurus) and 3/8 Nelore (Bos indicus) breed developed in Brazil, by evaluating the birth weight, weaning weight, yearling weight and plasma insulin-like growth factor-1 (IGF-1) concentration of 7 month to 10 months old Canchim calves (n = 204) of known genealogy and which had been genotyped for the AluI and DdeI markers. Our results showed significant effect (p < 0.05) between the homozygous DdeI+/DdeI+ polymorphism and the estimated breeding value for weaning weight (ESB-WW), while the AluI leucine homozygous (L/L) and leucine/valine (L/ V) heterozygous polymorphisms showed no significant effect on the traits studied. The restriction sites of the two enzymes led to the formation of haplotypes which also exerted a significant effect (p < 0.05) on the ESB-WW, with the largest difference being 8.5 kg in favor of the homozygous L plus DdeI+/L plus DdeI+ genotype over the heterozygous L plus DdeI-/V plus DdeI+ genotype. Copyright © 2008, Sociedade Brasileira de Genética. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 2022-04-28T20:50:24Z 2022-04-28T20:50:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1415-47572008000500012 Genetics and Molecular Biology, v. 31, n. 4, p. 874-879, 2008. 1678-4685 1415-4757 http://hdl.handle.net/11449/225438 10.1590/S1415-47572008000500012 2-s2.0-62549119059 |
url |
http://dx.doi.org/10.1590/S1415-47572008000500012 http://hdl.handle.net/11449/225438 |
identifier_str_mv |
Genetics and Molecular Biology, v. 31, n. 4, p. 874-879, 2008. 1678-4685 1415-4757 10.1590/S1415-47572008000500012 2-s2.0-62549119059 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Genetics and Molecular Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
874-879 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965490677809152 |