The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.1016/j.lfs.2022.120959 http://hdl.handle.net/11449/249155 |
Resumo: | Aim: To evaluate the influence of high-intensity interval training (HIIT) on cardiac structural and functional characteristics and myocardial mitogen-activated protein kinase (MAPK) signaling in hypertensive rats. Methods: Male rats (12 months old) were divided into three groups: Wistar Kyoto rats (WKY, n = 8); sedentary spontaneously hypertensive rats (SED-SHR, n = 10), and trained spontaneously hypertensive rats (HIIT-SHR, n = 10). Systolic blood pressure (SBP), functional capacity, echocardiography, isolated papillary muscle, and gene expression of MAPK gene-encoding proteins associated with Elk1, cJun, ATF2, MEF2 were analyzed. Key findings: HIIT decreased SBP and increased functional capacity, left ventricular diastolic diameter, posterior wall thickness-left ventricle, relative wall thickness-left ventricle, and resting tension of the papillary muscle. In hypertensive rats, we observed a decrease in the gene-encoding ATF2 protein; this decrease was reversed by HIIT. Significance: The influence of HIIT in the SHR model in the compensated hypertension phase generated an increase in cardiac hypertrophy, attenuated myocardial diastolic dysfunction, lowered blood pressure, improved functional capacity, and reversed the alteration in gene-encoding ATF2 protein. |
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The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive ratsHypertensionMAP kinase signaling systemPapillary musclesPhysical exerciseAim: To evaluate the influence of high-intensity interval training (HIIT) on cardiac structural and functional characteristics and myocardial mitogen-activated protein kinase (MAPK) signaling in hypertensive rats. Methods: Male rats (12 months old) were divided into three groups: Wistar Kyoto rats (WKY, n = 8); sedentary spontaneously hypertensive rats (SED-SHR, n = 10), and trained spontaneously hypertensive rats (HIIT-SHR, n = 10). Systolic blood pressure (SBP), functional capacity, echocardiography, isolated papillary muscle, and gene expression of MAPK gene-encoding proteins associated with Elk1, cJun, ATF2, MEF2 were analyzed. Key findings: HIIT decreased SBP and increased functional capacity, left ventricular diastolic diameter, posterior wall thickness-left ventricle, relative wall thickness-left ventricle, and resting tension of the papillary muscle. In hypertensive rats, we observed a decrease in the gene-encoding ATF2 protein; this decrease was reversed by HIIT. Significance: The influence of HIIT in the SHR model in the compensated hypertension phase generated an increase in cardiac hypertrophy, attenuated myocardial diastolic dysfunction, lowered blood pressure, improved functional capacity, and reversed the alteration in gene-encoding ATF2 protein.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)University of Western São Paulo (UNOESTE), SPSão Paulo State University (UNESP), SPUniversity of Northern Paraná (UNOPAR), PRUniversity of Nebraska-Lincoln Department of Nutrition and Health SciencesSão Paulo State University (UNESP), SPCAPES: 001CNPq: 139942/2017-3University of Western São Paulo (UNOESTE)Universidade Estadual Paulista (UNESP)University of Northern Paraná (UNOPAR)University of Nebraska-LincolnEngel, Letícia Estevamde Souza, Francilene Lima AgostinhoGiometti, Ines CristinaOkoshi, Katashi [UNESP]Mariano, Thaoan BrunoFerreira, Natalia ZamberlanPinheiro, Dyovana GomesFloriano, Rafael StuaniAguiar, Andreo FernandoCicogna, Antônio Carlos [UNESP]Vechetti, Ivan JoséPacagnelli, Francis Lopes2023-07-29T14:03:57Z2023-07-29T14:03:57Z2022-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.lfs.2022.120959Life Sciences, v. 308.1879-06310024-3205http://hdl.handle.net/11449/24915510.1016/j.lfs.2022.1209592-s2.0-85138105542Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLife Sciencesinfo:eu-repo/semantics/openAccess2023-07-29T14:03:57Zoai:repositorio.unesp.br:11449/249155Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T14:03:57Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats |
| title |
The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats |
| spellingShingle |
The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats Engel, Letícia Estevam Hypertension MAP kinase signaling system Papillary muscles Physical exercise |
| title_short |
The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats |
| title_full |
The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats |
| title_fullStr |
The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats |
| title_full_unstemmed |
The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats |
| title_sort |
The high-intensity interval training mitigates the cardiac remodeling in spontaneously hypertensive rats |
| author |
Engel, Letícia Estevam |
| author_facet |
Engel, Letícia Estevam de Souza, Francilene Lima Agostinho Giometti, Ines Cristina Okoshi, Katashi [UNESP] Mariano, Thaoan Bruno Ferreira, Natalia Zamberlan Pinheiro, Dyovana Gomes Floriano, Rafael Stuani Aguiar, Andreo Fernando Cicogna, Antônio Carlos [UNESP] Vechetti, Ivan José Pacagnelli, Francis Lopes |
| author_role |
author |
| author2 |
de Souza, Francilene Lima Agostinho Giometti, Ines Cristina Okoshi, Katashi [UNESP] Mariano, Thaoan Bruno Ferreira, Natalia Zamberlan Pinheiro, Dyovana Gomes Floriano, Rafael Stuani Aguiar, Andreo Fernando Cicogna, Antônio Carlos [UNESP] Vechetti, Ivan José Pacagnelli, Francis Lopes |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
University of Western São Paulo (UNOESTE) Universidade Estadual Paulista (UNESP) University of Northern Paraná (UNOPAR) University of Nebraska-Lincoln |
| dc.contributor.author.fl_str_mv |
Engel, Letícia Estevam de Souza, Francilene Lima Agostinho Giometti, Ines Cristina Okoshi, Katashi [UNESP] Mariano, Thaoan Bruno Ferreira, Natalia Zamberlan Pinheiro, Dyovana Gomes Floriano, Rafael Stuani Aguiar, Andreo Fernando Cicogna, Antônio Carlos [UNESP] Vechetti, Ivan José Pacagnelli, Francis Lopes |
| dc.subject.por.fl_str_mv |
Hypertension MAP kinase signaling system Papillary muscles Physical exercise |
| topic |
Hypertension MAP kinase signaling system Papillary muscles Physical exercise |
| description |
Aim: To evaluate the influence of high-intensity interval training (HIIT) on cardiac structural and functional characteristics and myocardial mitogen-activated protein kinase (MAPK) signaling in hypertensive rats. Methods: Male rats (12 months old) were divided into three groups: Wistar Kyoto rats (WKY, n = 8); sedentary spontaneously hypertensive rats (SED-SHR, n = 10), and trained spontaneously hypertensive rats (HIIT-SHR, n = 10). Systolic blood pressure (SBP), functional capacity, echocardiography, isolated papillary muscle, and gene expression of MAPK gene-encoding proteins associated with Elk1, cJun, ATF2, MEF2 were analyzed. Key findings: HIIT decreased SBP and increased functional capacity, left ventricular diastolic diameter, posterior wall thickness-left ventricle, relative wall thickness-left ventricle, and resting tension of the papillary muscle. In hypertensive rats, we observed a decrease in the gene-encoding ATF2 protein; this decrease was reversed by HIIT. Significance: The influence of HIIT in the SHR model in the compensated hypertension phase generated an increase in cardiac hypertrophy, attenuated myocardial diastolic dysfunction, lowered blood pressure, improved functional capacity, and reversed the alteration in gene-encoding ATF2 protein. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-01 2023-07-29T14:03:57Z 2023-07-29T14:03:57Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.lfs.2022.120959 Life Sciences, v. 308. 1879-0631 0024-3205 http://hdl.handle.net/11449/249155 10.1016/j.lfs.2022.120959 2-s2.0-85138105542 |
| url |
http://dx.doi.org/10.1016/j.lfs.2022.120959 http://hdl.handle.net/11449/249155 |
| identifier_str_mv |
Life Sciences, v. 308. 1879-0631 0024-3205 10.1016/j.lfs.2022.120959 2-s2.0-85138105542 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Life Sciences |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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1803046361011060736 |