Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3?
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bbr.2021.113566 http://hdl.handle.net/11449/233545 |
Resumo: | The present study evaluated the function of the right and left CA3 of the dorsal hippocampus (dHPC) in the processing of (i) recognition memory, (ii) recent and remote spatial memory, (iii) working memory and (iv) navigation strategy. Wistar rats were divided into four experimental groups: vehicle group (VG), animals received a bilateral injection of phosphate-saline buffer (PBS) in both right and left dorsal CA3; dHPC-R group, animals received an injection of ibotenic acid (IBO) in the right dorsal CA3; dHPC-L group, animals received an IBO injection in left dorsal CA3; and dHPC-Bi group, animals received bilateral injections of IBO in both dorsal CA3. Rats were submitted to a sequence of behavioral tests: Morris water maze (MWM), object recognition test (ORT), forced T-maze and MWM 30 days after the first exposure. The results showed no evidence of functional lateralization and the dorsal CA3 does not seem to be essential for learning and memory (recent and remote) processing and allocentric navigation analyzed in the MWM and T-maze, respectively. However, rats with right or bilateral lesions in the dorsal CA3 failed to recognize the familiar object in the ORT, suggesting a lateralized processing of recognition memory. That result is unprecedented and contributes to the knowledge about the compartmentalization of HPC functions. |
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Repositório Institucional da UNESP |
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Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3?Dorsal CA3Dorsal hippocampusEpisodic memoryFunctional lateralizationRecognitionThe present study evaluated the function of the right and left CA3 of the dorsal hippocampus (dHPC) in the processing of (i) recognition memory, (ii) recent and remote spatial memory, (iii) working memory and (iv) navigation strategy. Wistar rats were divided into four experimental groups: vehicle group (VG), animals received a bilateral injection of phosphate-saline buffer (PBS) in both right and left dorsal CA3; dHPC-R group, animals received an injection of ibotenic acid (IBO) in the right dorsal CA3; dHPC-L group, animals received an IBO injection in left dorsal CA3; and dHPC-Bi group, animals received bilateral injections of IBO in both dorsal CA3. Rats were submitted to a sequence of behavioral tests: Morris water maze (MWM), object recognition test (ORT), forced T-maze and MWM 30 days after the first exposure. The results showed no evidence of functional lateralization and the dorsal CA3 does not seem to be essential for learning and memory (recent and remote) processing and allocentric navigation analyzed in the MWM and T-maze, respectively. However, rats with right or bilateral lesions in the dorsal CA3 failed to recognize the familiar object in the ORT, suggesting a lateralized processing of recognition memory. That result is unprecedented and contributes to the knowledge about the compartmentalization of HPC functions.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Zoology and Botany Universidade Estadual Paulista (UNESP), Rua Cristóvão Colombo, 2265Graduate Program in Animal Biology Universidade Estadual Paulista (UNESP), Rua Cristóvão Colombo, 2265̥Join Graduate Program in Physiological Sciences Universidade Federal de São Carlos/Universidade Estadual Paulista (UFSCar/UNESP), Rodovia Washington Luiz, km 235̥Department of Zoology and Botany Universidade Estadual Paulista (UNESP), Rua Cristóvão Colombo, 2265Graduate Program in Animal Biology Universidade Estadual Paulista (UNESP), Rua Cristóvão Colombo, 2265̥Join Graduate Program in Physiological Sciences Universidade Federal de São Carlos/Universidade Estadual Paulista (UFSCar/UNESP), Rodovia Washington Luiz, km 235̥FAPESP: 089/2019CNPq: 131146/2018-1CNPq: 153162/2016-2FAPESP: 2016/07464-0Universidade Estadual Paulista (UNESP)Pimentel, Gabrielle Araujo [UNESP]Crestani, Ariela Maltarolo [UNESP]Florindo, Luiz Henrique [UNESP]2022-05-01T09:30:31Z2022-05-01T09:30:31Z2022-01-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bbr.2021.113566Behavioural Brain Research, v. 416.1872-75490166-4328http://hdl.handle.net/11449/23354510.1016/j.bbr.2021.1135662-s2.0-85115023017Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBehavioural Brain Researchinfo:eu-repo/semantics/openAccess2022-05-01T09:30:31Zoai:repositorio.unesp.br:11449/233545Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-05-01T09:30:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3? |
title |
Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3? |
spellingShingle |
Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3? Pimentel, Gabrielle Araujo [UNESP] Dorsal CA3 Dorsal hippocampus Episodic memory Functional lateralization Recognition |
title_short |
Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3? |
title_full |
Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3? |
title_fullStr |
Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3? |
title_full_unstemmed |
Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3? |
title_sort |
Do spatial and recognition memories have a lateralized processing by the dorsal hippocampus CA3? |
author |
Pimentel, Gabrielle Araujo [UNESP] |
author_facet |
Pimentel, Gabrielle Araujo [UNESP] Crestani, Ariela Maltarolo [UNESP] Florindo, Luiz Henrique [UNESP] |
author_role |
author |
author2 |
Crestani, Ariela Maltarolo [UNESP] Florindo, Luiz Henrique [UNESP] |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Pimentel, Gabrielle Araujo [UNESP] Crestani, Ariela Maltarolo [UNESP] Florindo, Luiz Henrique [UNESP] |
dc.subject.por.fl_str_mv |
Dorsal CA3 Dorsal hippocampus Episodic memory Functional lateralization Recognition |
topic |
Dorsal CA3 Dorsal hippocampus Episodic memory Functional lateralization Recognition |
description |
The present study evaluated the function of the right and left CA3 of the dorsal hippocampus (dHPC) in the processing of (i) recognition memory, (ii) recent and remote spatial memory, (iii) working memory and (iv) navigation strategy. Wistar rats were divided into four experimental groups: vehicle group (VG), animals received a bilateral injection of phosphate-saline buffer (PBS) in both right and left dorsal CA3; dHPC-R group, animals received an injection of ibotenic acid (IBO) in the right dorsal CA3; dHPC-L group, animals received an IBO injection in left dorsal CA3; and dHPC-Bi group, animals received bilateral injections of IBO in both dorsal CA3. Rats were submitted to a sequence of behavioral tests: Morris water maze (MWM), object recognition test (ORT), forced T-maze and MWM 30 days after the first exposure. The results showed no evidence of functional lateralization and the dorsal CA3 does not seem to be essential for learning and memory (recent and remote) processing and allocentric navigation analyzed in the MWM and T-maze, respectively. However, rats with right or bilateral lesions in the dorsal CA3 failed to recognize the familiar object in the ORT, suggesting a lateralized processing of recognition memory. That result is unprecedented and contributes to the knowledge about the compartmentalization of HPC functions. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-01T09:30:31Z 2022-05-01T09:30:31Z 2022-01-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bbr.2021.113566 Behavioural Brain Research, v. 416. 1872-7549 0166-4328 http://hdl.handle.net/11449/233545 10.1016/j.bbr.2021.113566 2-s2.0-85115023017 |
url |
http://dx.doi.org/10.1016/j.bbr.2021.113566 http://hdl.handle.net/11449/233545 |
identifier_str_mv |
Behavioural Brain Research, v. 416. 1872-7549 0166-4328 10.1016/j.bbr.2021.113566 2-s2.0-85115023017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Behavioural Brain Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803650372915429376 |