Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ntt.2014.10.001 http://hdl.handle.net/11449/183922 |
Resumo: | Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forced swim test (FST) in behavioral tasks related to anxiety, serum corticosterone levels, and striatal neurotransmitter levels. Open field behavior and social interaction were evaluated after DTM administration (10 mg kg(-1), p.o). DTM per se reduced rearing frequency in the open field, but no alterations in locomotion frequency or immobility duration were detected. Stress increased immobility duration compared with non-stressed animals. DTM reduced social interaction and increased corticosterone levels, and these effects were enhanced in stressed animals. Mainly stress affected dopaminergic and serotoninergic activity. In anxiety behavior and in both neurotransmitters and metabolites levels it was observed an additive effect of stress in DTM treated rat data. These results indicate that DTM enhanced the anxiogenic responses and stress had an additive effect over the DTM stress. The neurochemical data did not indicate an interaction between stress and DTM exposure. The present results may be important for implementing pyrethroid insecticide safety standards. (C) 2014 Elsevier Inc. All rights reserved. |
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spelling |
Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrinDeltamethrinPyrethroidPesticideForced swimmingAnxietyStressDeltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forced swim test (FST) in behavioral tasks related to anxiety, serum corticosterone levels, and striatal neurotransmitter levels. Open field behavior and social interaction were evaluated after DTM administration (10 mg kg(-1), p.o). DTM per se reduced rearing frequency in the open field, but no alterations in locomotion frequency or immobility duration were detected. Stress increased immobility duration compared with non-stressed animals. DTM reduced social interaction and increased corticosterone levels, and these effects were enhanced in stressed animals. Mainly stress affected dopaminergic and serotoninergic activity. In anxiety behavior and in both neurotransmitters and metabolites levels it was observed an additive effect of stress in DTM treated rat data. These results indicate that DTM enhanced the anxiogenic responses and stress had an additive effect over the DTM stress. The neurochemical data did not indicate an interaction between stress and DTM exposure. The present results may be important for implementing pyrethroid insecticide safety standards. (C) 2014 Elsevier Inc. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, UNIP, Grad Program Environm & Expt Pathol, BR-04026002 Sao Paulo, BrazilUniv Estadual Paulista, UNIP, Grad Program Dent, BR-04026002 Sao Paulo, BrazilUniv Sao Paulo, Dept Pathol, Sch Vet Med & Anim Sci, Sao Paulo, BrazilUniv Estadual Paulista, UNIP, Grad Program Environm & Expt Pathol, BR-04026002 Sao Paulo, BrazilUniv Estadual Paulista, UNIP, Grad Program Dent, BR-04026002 Sao Paulo, BrazilFAPESP: 9912319-2Elsevier B.V.Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Habr, Soraya F. [UNESP]Macrini, Dacle J. [UNESP]Spinosa, Helenice de S.Florio, Jorge C.Bernardi, Maria M. [UNESP]2019-10-03T18:18:22Z2019-10-03T18:18:22Z2014-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article57-61http://dx.doi.org/10.1016/j.ntt.2014.10.001Neurotoxicology And Teratology. Oxford: Pergamon-elsevier Science Ltd, v. 46, p. 57-61, 2014.0892-0362http://hdl.handle.net/11449/18392210.1016/j.ntt.2014.10.001WOS:000348006100008Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNeurotoxicology And Teratologyinfo:eu-repo/semantics/openAccess2021-10-23T19:28:25Zoai:repositorio.unesp.br:11449/183922Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:28:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin |
title |
Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin |
spellingShingle |
Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin Habr, Soraya F. [UNESP] Deltamethrin Pyrethroid Pesticide Forced swimming Anxiety Stress |
title_short |
Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin |
title_full |
Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin |
title_fullStr |
Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin |
title_full_unstemmed |
Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin |
title_sort |
Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin |
author |
Habr, Soraya F. [UNESP] |
author_facet |
Habr, Soraya F. [UNESP] Macrini, Dacle J. [UNESP] Spinosa, Helenice de S. Florio, Jorge C. Bernardi, Maria M. [UNESP] |
author_role |
author |
author2 |
Macrini, Dacle J. [UNESP] Spinosa, Helenice de S. Florio, Jorge C. Bernardi, Maria M. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Habr, Soraya F. [UNESP] Macrini, Dacle J. [UNESP] Spinosa, Helenice de S. Florio, Jorge C. Bernardi, Maria M. [UNESP] |
dc.subject.por.fl_str_mv |
Deltamethrin Pyrethroid Pesticide Forced swimming Anxiety Stress |
topic |
Deltamethrin Pyrethroid Pesticide Forced swimming Anxiety Stress |
description |
Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forced swim test (FST) in behavioral tasks related to anxiety, serum corticosterone levels, and striatal neurotransmitter levels. Open field behavior and social interaction were evaluated after DTM administration (10 mg kg(-1), p.o). DTM per se reduced rearing frequency in the open field, but no alterations in locomotion frequency or immobility duration were detected. Stress increased immobility duration compared with non-stressed animals. DTM reduced social interaction and increased corticosterone levels, and these effects were enhanced in stressed animals. Mainly stress affected dopaminergic and serotoninergic activity. In anxiety behavior and in both neurotransmitters and metabolites levels it was observed an additive effect of stress in DTM treated rat data. These results indicate that DTM enhanced the anxiogenic responses and stress had an additive effect over the DTM stress. The neurochemical data did not indicate an interaction between stress and DTM exposure. The present results may be important for implementing pyrethroid insecticide safety standards. (C) 2014 Elsevier Inc. All rights reserved. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-11-01 2019-10-03T18:18:22Z 2019-10-03T18:18:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ntt.2014.10.001 Neurotoxicology And Teratology. Oxford: Pergamon-elsevier Science Ltd, v. 46, p. 57-61, 2014. 0892-0362 http://hdl.handle.net/11449/183922 10.1016/j.ntt.2014.10.001 WOS:000348006100008 |
url |
http://dx.doi.org/10.1016/j.ntt.2014.10.001 http://hdl.handle.net/11449/183922 |
identifier_str_mv |
Neurotoxicology And Teratology. Oxford: Pergamon-elsevier Science Ltd, v. 46, p. 57-61, 2014. 0892-0362 10.1016/j.ntt.2014.10.001 WOS:000348006100008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neurotoxicology And Teratology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
57-61 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803045980596076544 |