Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-736X2016000100001 http://hdl.handle.net/11449/172829 |
Resumo: | The urinary acidification with ammonium chloride (AC) is an efficient preventive method for urolithiasis in sheep. The objectives of this study with feedlot sheep receiving concentrated diet with high protein content were (1) to verify the effect of diet on urolith formation and development of the disease, (2) to analyze the macroscopic and histopathological characteristics of the urinary system, and (3) to relate the clinical, laboratory and necropsy findings with the presence of uroliths. Sixty male sheep were used: AC group (n=40), 400mg/kg AC/day, orally treated for 42 consecutive days, and control group (n=20), untreated. Seven times were determined for sampling with a seven-day interval, totaling 56 days of feedlot. Small uroliths were found in the renal pelvis of five sheep in both groups. The most relevant microscopic renal lesions were vascular congestion and tubular necrosis. It was concluded that the highly concentrated diet caused renal injury in both groups, without changing the renal function, what was proven by laboratory tests of urea and creatinine. Ammonium chloride provided to the CA group did not prevent urolith formation, but reduced its prevalence in comparison with the control group. Sheep of the control group had increased kidney damage, which resulted in higher incidence of crystalluria and tubular necrosis induced by the consumption of a diet rich in grains. |
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Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônioClinical, laboratory and anatomopathological evaluation of the urinary system of feedlot sheep with or without ammonium chloride supplementationHistopatholgyKidneysSmall ruminantsUrinary acidifiersUrolithiasisThe urinary acidification with ammonium chloride (AC) is an efficient preventive method for urolithiasis in sheep. The objectives of this study with feedlot sheep receiving concentrated diet with high protein content were (1) to verify the effect of diet on urolith formation and development of the disease, (2) to analyze the macroscopic and histopathological characteristics of the urinary system, and (3) to relate the clinical, laboratory and necropsy findings with the presence of uroliths. Sixty male sheep were used: AC group (n=40), 400mg/kg AC/day, orally treated for 42 consecutive days, and control group (n=20), untreated. Seven times were determined for sampling with a seven-day interval, totaling 56 days of feedlot. Small uroliths were found in the renal pelvis of five sheep in both groups. The most relevant microscopic renal lesions were vascular congestion and tubular necrosis. It was concluded that the highly concentrated diet caused renal injury in both groups, without changing the renal function, what was proven by laboratory tests of urea and creatinine. Ammonium chloride provided to the CA group did not prevent urolith formation, but reduced its prevalence in comparison with the control group. Sheep of the control group had increased kidney damage, which resulted in higher incidence of crystalluria and tubular necrosis induced by the consumption of a diet rich in grains.Departamento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista (Unesp), Campus de Botucatu, Distrito de Rubiao Junior s/nSecretaria da Agricultura e Abastecimento do estado de São Paulo Coordenadoria de Assistência Técnica Integral Casa da Agricultura de Agudos, Rua Odom Pessoa de Albuquerque 788Departamento de Saúde Pública Faculdade de Medicina de Botucatu (FMB) Universidade Estadual Paulista (Unesp), Campus de Botucatu, Distrito de Rubiao Junior s/nDepartamento de Clínica Veterinária Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista (Unesp), Campus de Botucatu, Distrito de Rubiao Junior s/nDepartamento de Saúde Pública Faculdade de Medicina de Botucatu (FMB) Universidade Estadual Paulista (Unesp), Campus de Botucatu, Distrito de Rubiao Junior s/nUniversidade Estadual Paulista (Unesp)Casa da Agricultura de AgudosSantarosa, Bianca P. [UNESP]Ferreira, Danilo O.L.Rodrigues, Marcela M.P. [UNESP]Dantas, Gabriela N. [UNESP]Sacco, Soraya R. [UNESP]Lopes, Raimundo Souza [UNESP]Dias, Adriano [UNESP]Gonçalves, Roberto C. [UNESP]2018-12-11T17:02:20Z2018-12-11T17:02:20Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-12application/pdfhttp://dx.doi.org/10.1590/S0100-736X2016000100001Pesquisa Veterinaria Brasileira, v. 36, n. 1, p. 1-12, 2016.1678-51500100-736Xhttp://hdl.handle.net/11449/17282910.1590/S0100-736X2016000100001S0100-736X20160001000012-s2.0-84963728973S0100-736X2016000100001.pdf29668464060628360000-0001-6895-372XScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporPesquisa Veterinaria Brasileirainfo:eu-repo/semantics/openAccess2024-01-11T06:27:29Zoai:repositorio.unesp.br:11449/172829Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-11T06:27:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio Clinical, laboratory and anatomopathological evaluation of the urinary system of feedlot sheep with or without ammonium chloride supplementation |
title |
Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio |
spellingShingle |
Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio Santarosa, Bianca P. [UNESP] Histopatholgy Kidneys Small ruminants Urinary acidifiers Urolithiasis |
title_short |
Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio |
title_full |
Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio |
title_fullStr |
Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio |
title_full_unstemmed |
Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio |
title_sort |
Avaliação clínica, laboratorial e anatomopatológica do sistema urinário de ovinos confinados com ou sem suplementação de cloreto de amônio |
author |
Santarosa, Bianca P. [UNESP] |
author_facet |
Santarosa, Bianca P. [UNESP] Ferreira, Danilo O.L. Rodrigues, Marcela M.P. [UNESP] Dantas, Gabriela N. [UNESP] Sacco, Soraya R. [UNESP] Lopes, Raimundo Souza [UNESP] Dias, Adriano [UNESP] Gonçalves, Roberto C. [UNESP] |
author_role |
author |
author2 |
Ferreira, Danilo O.L. Rodrigues, Marcela M.P. [UNESP] Dantas, Gabriela N. [UNESP] Sacco, Soraya R. [UNESP] Lopes, Raimundo Souza [UNESP] Dias, Adriano [UNESP] Gonçalves, Roberto C. [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Casa da Agricultura de Agudos |
dc.contributor.author.fl_str_mv |
Santarosa, Bianca P. [UNESP] Ferreira, Danilo O.L. Rodrigues, Marcela M.P. [UNESP] Dantas, Gabriela N. [UNESP] Sacco, Soraya R. [UNESP] Lopes, Raimundo Souza [UNESP] Dias, Adriano [UNESP] Gonçalves, Roberto C. [UNESP] |
dc.subject.por.fl_str_mv |
Histopatholgy Kidneys Small ruminants Urinary acidifiers Urolithiasis |
topic |
Histopatholgy Kidneys Small ruminants Urinary acidifiers Urolithiasis |
description |
The urinary acidification with ammonium chloride (AC) is an efficient preventive method for urolithiasis in sheep. The objectives of this study with feedlot sheep receiving concentrated diet with high protein content were (1) to verify the effect of diet on urolith formation and development of the disease, (2) to analyze the macroscopic and histopathological characteristics of the urinary system, and (3) to relate the clinical, laboratory and necropsy findings with the presence of uroliths. Sixty male sheep were used: AC group (n=40), 400mg/kg AC/day, orally treated for 42 consecutive days, and control group (n=20), untreated. Seven times were determined for sampling with a seven-day interval, totaling 56 days of feedlot. Small uroliths were found in the renal pelvis of five sheep in both groups. The most relevant microscopic renal lesions were vascular congestion and tubular necrosis. It was concluded that the highly concentrated diet caused renal injury in both groups, without changing the renal function, what was proven by laboratory tests of urea and creatinine. Ammonium chloride provided to the CA group did not prevent urolith formation, but reduced its prevalence in comparison with the control group. Sheep of the control group had increased kidney damage, which resulted in higher incidence of crystalluria and tubular necrosis induced by the consumption of a diet rich in grains. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2018-12-11T17:02:20Z 2018-12-11T17:02:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-736X2016000100001 Pesquisa Veterinaria Brasileira, v. 36, n. 1, p. 1-12, 2016. 1678-5150 0100-736X http://hdl.handle.net/11449/172829 10.1590/S0100-736X2016000100001 S0100-736X2016000100001 2-s2.0-84963728973 S0100-736X2016000100001.pdf 2966846406062836 0000-0001-6895-372X |
url |
http://dx.doi.org/10.1590/S0100-736X2016000100001 http://hdl.handle.net/11449/172829 |
identifier_str_mv |
Pesquisa Veterinaria Brasileira, v. 36, n. 1, p. 1-12, 2016. 1678-5150 0100-736X 10.1590/S0100-736X2016000100001 S0100-736X2016000100001 2-s2.0-84963728973 S0100-736X2016000100001.pdf 2966846406062836 0000-0001-6895-372X |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Pesquisa Veterinaria Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-12 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1799965584990928896 |