Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats

Detalhes bibliográficos
Autor(a) principal: Vieira, Jonas O. [UNESP]
Data de Publicação: 2018
Outros Autores: Duarte, Josiane O. [UNESP], Costa-Ferreira, Willian [UNESP], Morais-Silva, Gessynger [UNESP], Marin, Marcelo T. [UNESP], Crestani, Carlos C. [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.pnpbp.2017.08.014
http://hdl.handle.net/11449/170064
Resumo: This study investigated the physiological, somatic and behavioral changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in male and female rats. For this, adult Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor). Effects evoked by CVS included: (i) adrenal hypertrophy and decreased body weight gain in male animals, (ii) a sympathetically-mediated increase in basal heart rate in males, and (iii) a rise in plasma corticosterone concentration and anxiogenic effects in female animals. The homotypic stressor RRS also induced an increase in plasma corticosterone and anxiogenic effects in females, decreased body weight gain in males and evoked a sympathetically-mediated increase in heart rate in both sexes. Changes in cardiovascular function and autonomic activity evoked by both stressors were followed by impairment of baroreflex activity in males, but not female animals. Both chronic stressors evoked changes in blood pressure responsiveness to vasoconstrictor and vasodilator agents in both sexes. Taken together, these results indicate that regardless of chronic stress regimen males are more vulnerable to somatic effects of chronic stressors, while females appear to be more susceptible to neuroendocrine and behavioral changes. Present findings also indicate that females are selectively vulnerable to cardiovascular and autonomic changes evoked by homotypic stressors. Nevertheless, homotypic and heterotypic stressors similarly affect cardiovascular function and autonomic activity in males.
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spelling Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in ratsAutonomic activityBaroreflexHPA axisRestraint stressUnpredictable stressVascularThis study investigated the physiological, somatic and behavioral changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in male and female rats. For this, adult Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor). Effects evoked by CVS included: (i) adrenal hypertrophy and decreased body weight gain in male animals, (ii) a sympathetically-mediated increase in basal heart rate in males, and (iii) a rise in plasma corticosterone concentration and anxiogenic effects in female animals. The homotypic stressor RRS also induced an increase in plasma corticosterone and anxiogenic effects in females, decreased body weight gain in males and evoked a sympathetically-mediated increase in heart rate in both sexes. Changes in cardiovascular function and autonomic activity evoked by both stressors were followed by impairment of baroreflex activity in males, but not female animals. Both chronic stressors evoked changes in blood pressure responsiveness to vasoconstrictor and vasodilator agents in both sexes. Taken together, these results indicate that regardless of chronic stress regimen males are more vulnerable to somatic effects of chronic stressors, while females appear to be more susceptible to neuroendocrine and behavioral changes. Present findings also indicate that females are selectively vulnerable to cardiovascular and autonomic changes evoked by homotypic stressors. Nevertheless, homotypic and heterotypic stressors similarly affect cardiovascular function and autonomic activity in males.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Laboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical SciencesJoint UFSCar-UNESP Graduate Program in Physiological SciencesLaboratory of Pharmacology São Paulo State University (UNESP) School of Pharmaceutical SciencesJoint UFSCar-UNESP Graduate Program in Physiological SciencesFAPESP: 2012/14376-0FAPESP: 2015/05922-9CNPq: 305583/2015-8CNPq: 456405/2014-3Universidade Estadual Paulista (Unesp)Vieira, Jonas O. [UNESP]Duarte, Josiane O. [UNESP]Costa-Ferreira, Willian [UNESP]Morais-Silva, Gessynger [UNESP]Marin, Marcelo T. [UNESP]Crestani, Carlos C. [UNESP]2018-12-11T16:48:58Z2018-12-11T16:48:58Z2018-02-02info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article426-437application/pdfhttp://dx.doi.org/10.1016/j.pnpbp.2017.08.014Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 81, p. 426-437.1878-42160278-5846http://hdl.handle.net/11449/17006410.1016/j.pnpbp.2017.08.0142-s2.0-850283372952-s2.0-85028337295.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProgress in Neuro-Psychopharmacology and Biological Psychiatry1,714info:eu-repo/semantics/openAccess2023-12-04T06:18:32Zoai:repositorio.unesp.br:11449/170064Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:30:39.725182Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats
title Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats
spellingShingle Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats
Vieira, Jonas O. [UNESP]
Autonomic activity
Baroreflex
HPA axis
Restraint stress
Unpredictable stress
Vascular
title_short Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats
title_full Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats
title_fullStr Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats
title_full_unstemmed Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats
title_sort Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats
author Vieira, Jonas O. [UNESP]
author_facet Vieira, Jonas O. [UNESP]
Duarte, Josiane O. [UNESP]
Costa-Ferreira, Willian [UNESP]
Morais-Silva, Gessynger [UNESP]
Marin, Marcelo T. [UNESP]
Crestani, Carlos C. [UNESP]
author_role author
author2 Duarte, Josiane O. [UNESP]
Costa-Ferreira, Willian [UNESP]
Morais-Silva, Gessynger [UNESP]
Marin, Marcelo T. [UNESP]
Crestani, Carlos C. [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Vieira, Jonas O. [UNESP]
Duarte, Josiane O. [UNESP]
Costa-Ferreira, Willian [UNESP]
Morais-Silva, Gessynger [UNESP]
Marin, Marcelo T. [UNESP]
Crestani, Carlos C. [UNESP]
dc.subject.por.fl_str_mv Autonomic activity
Baroreflex
HPA axis
Restraint stress
Unpredictable stress
Vascular
topic Autonomic activity
Baroreflex
HPA axis
Restraint stress
Unpredictable stress
Vascular
description This study investigated the physiological, somatic and behavioral changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in male and female rats. For this, adult Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor). Effects evoked by CVS included: (i) adrenal hypertrophy and decreased body weight gain in male animals, (ii) a sympathetically-mediated increase in basal heart rate in males, and (iii) a rise in plasma corticosterone concentration and anxiogenic effects in female animals. The homotypic stressor RRS also induced an increase in plasma corticosterone and anxiogenic effects in females, decreased body weight gain in males and evoked a sympathetically-mediated increase in heart rate in both sexes. Changes in cardiovascular function and autonomic activity evoked by both stressors were followed by impairment of baroreflex activity in males, but not female animals. Both chronic stressors evoked changes in blood pressure responsiveness to vasoconstrictor and vasodilator agents in both sexes. Taken together, these results indicate that regardless of chronic stress regimen males are more vulnerable to somatic effects of chronic stressors, while females appear to be more susceptible to neuroendocrine and behavioral changes. Present findings also indicate that females are selectively vulnerable to cardiovascular and autonomic changes evoked by homotypic stressors. Nevertheless, homotypic and heterotypic stressors similarly affect cardiovascular function and autonomic activity in males.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T16:48:58Z
2018-12-11T16:48:58Z
2018-02-02
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.pnpbp.2017.08.014
Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 81, p. 426-437.
1878-4216
0278-5846
http://hdl.handle.net/11449/170064
10.1016/j.pnpbp.2017.08.014
2-s2.0-85028337295
2-s2.0-85028337295.pdf
url http://dx.doi.org/10.1016/j.pnpbp.2017.08.014
http://hdl.handle.net/11449/170064
identifier_str_mv Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 81, p. 426-437.
1878-4216
0278-5846
10.1016/j.pnpbp.2017.08.014
2-s2.0-85028337295
2-s2.0-85028337295.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Progress in Neuro-Psychopharmacology and Biological Psychiatry
1,714
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 426-437
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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