Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.surfcoat.2018.09.038 http://hdl.handle.net/11449/188160 |
Resumo: | Titanium and its alloys have been routinely used to replace bone and teeth. This success is mainly due to their remarkable clinical response, mechanical properties, chemical stability and appropriate biocompatibility associated to a titanium dioxide (TiO2) layer. Chemically, the TiO2 surface is mostly terminated by –OH groups. An increased amount of reactive –OH groups can be obtained by UV radiation treatment on TiO2 surface, which can be readily functionalized with bifunctional organic molecules. Among the several types of organic molecules available for reaction with –OH groups, bisphosphonates (BP) have been associated with a positive effect on new bone formation. In this way, the present contribution aims at giving an overview study from the physicochemical properties of two distinct BP (alendronate and risedronate), immobilized on the titanium surface containing hydroxylated TiO2 film by UV radiation. Surface properties such as contact angle, surface free energy and topography/roughness were evaluated. In addition, biocompatibility and mineralization tests performed with osteoblastic-like cells are presented to evaluate the potential of these functional materials to be applied in the dentistry and orthopedics fields. The results suggest that the UV treatment increased the surface wettability and allowed an oriented immobilization of BP. In addition, the BP functionalized surfaces exhibited high viability and mineralization of pre-osteoblast cells. Therefore, these compounds emerge as a potential treatment on implants surfaces. |
id |
UNSP_4f5c0b092bc532e463ec627b46b3e686 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/188160 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-applicationAlendronateBisphosphonateFunctionalizationRisedronate and bone implant materialsTitaniumTitanium dioxideTitanium and its alloys have been routinely used to replace bone and teeth. This success is mainly due to their remarkable clinical response, mechanical properties, chemical stability and appropriate biocompatibility associated to a titanium dioxide (TiO2) layer. Chemically, the TiO2 surface is mostly terminated by –OH groups. An increased amount of reactive –OH groups can be obtained by UV radiation treatment on TiO2 surface, which can be readily functionalized with bifunctional organic molecules. Among the several types of organic molecules available for reaction with –OH groups, bisphosphonates (BP) have been associated with a positive effect on new bone formation. In this way, the present contribution aims at giving an overview study from the physicochemical properties of two distinct BP (alendronate and risedronate), immobilized on the titanium surface containing hydroxylated TiO2 film by UV radiation. Surface properties such as contact angle, surface free energy and topography/roughness were evaluated. In addition, biocompatibility and mineralization tests performed with osteoblastic-like cells are presented to evaluate the potential of these functional materials to be applied in the dentistry and orthopedics fields. The results suggest that the UV treatment increased the surface wettability and allowed an oriented immobilization of BP. In addition, the BP functionalized surfaces exhibited high viability and mineralization of pre-osteoblast cells. Therefore, these compounds emerge as a potential treatment on implants surfaces.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)UNESP - São Paulo State University School of Sciences Department of Physics, BauruDepartment of Biological Sciences Bauru School of Dentistry University of São Paulo, BauruUNESP - São Paulo State University School of Sciences Department of Physics, BauruFAPESP: 2014/01713-3FAPESP: 2014/20471-0FAPESP: 2016/11183-7FAPESP: 2017/15035-5Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Bronze-Uhle, Erika S. [UNESP]Dias, Leonardo F.G. [UNESP]Trino, Luciana D. [UNESP]Matos, Adriana A.de Oliveira, Rodrigo C.Lisboa-Filho, Paulo N. [UNESP]2019-10-06T15:59:12Z2019-10-06T15:59:12Z2019-01-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article36-47http://dx.doi.org/10.1016/j.surfcoat.2018.09.038Surface and Coatings Technology, v. 357, p. 36-47.0257-8972http://hdl.handle.net/11449/18816010.1016/j.surfcoat.2018.09.0382-s2.0-8505445053813538624145320050000-0002-7734-4069Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSurface and Coatings Technologyinfo:eu-repo/semantics/openAccess2024-04-25T17:39:39Zoai:repositorio.unesp.br:11449/188160Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-25T17:39:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application |
title |
Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application |
spellingShingle |
Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application Bronze-Uhle, Erika S. [UNESP] Alendronate Bisphosphonate Functionalization Risedronate and bone implant materials Titanium Titanium dioxide |
title_short |
Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application |
title_full |
Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application |
title_fullStr |
Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application |
title_full_unstemmed |
Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application |
title_sort |
Physicochemical bisphosphonate immobilization on titanium dioxide thin films surface by UV radiation for bio-application |
author |
Bronze-Uhle, Erika S. [UNESP] |
author_facet |
Bronze-Uhle, Erika S. [UNESP] Dias, Leonardo F.G. [UNESP] Trino, Luciana D. [UNESP] Matos, Adriana A. de Oliveira, Rodrigo C. Lisboa-Filho, Paulo N. [UNESP] |
author_role |
author |
author2 |
Dias, Leonardo F.G. [UNESP] Trino, Luciana D. [UNESP] Matos, Adriana A. de Oliveira, Rodrigo C. Lisboa-Filho, Paulo N. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Bronze-Uhle, Erika S. [UNESP] Dias, Leonardo F.G. [UNESP] Trino, Luciana D. [UNESP] Matos, Adriana A. de Oliveira, Rodrigo C. Lisboa-Filho, Paulo N. [UNESP] |
dc.subject.por.fl_str_mv |
Alendronate Bisphosphonate Functionalization Risedronate and bone implant materials Titanium Titanium dioxide |
topic |
Alendronate Bisphosphonate Functionalization Risedronate and bone implant materials Titanium Titanium dioxide |
description |
Titanium and its alloys have been routinely used to replace bone and teeth. This success is mainly due to their remarkable clinical response, mechanical properties, chemical stability and appropriate biocompatibility associated to a titanium dioxide (TiO2) layer. Chemically, the TiO2 surface is mostly terminated by –OH groups. An increased amount of reactive –OH groups can be obtained by UV radiation treatment on TiO2 surface, which can be readily functionalized with bifunctional organic molecules. Among the several types of organic molecules available for reaction with –OH groups, bisphosphonates (BP) have been associated with a positive effect on new bone formation. In this way, the present contribution aims at giving an overview study from the physicochemical properties of two distinct BP (alendronate and risedronate), immobilized on the titanium surface containing hydroxylated TiO2 film by UV radiation. Surface properties such as contact angle, surface free energy and topography/roughness were evaluated. In addition, biocompatibility and mineralization tests performed with osteoblastic-like cells are presented to evaluate the potential of these functional materials to be applied in the dentistry and orthopedics fields. The results suggest that the UV treatment increased the surface wettability and allowed an oriented immobilization of BP. In addition, the BP functionalized surfaces exhibited high viability and mineralization of pre-osteoblast cells. Therefore, these compounds emerge as a potential treatment on implants surfaces. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T15:59:12Z 2019-10-06T15:59:12Z 2019-01-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.surfcoat.2018.09.038 Surface and Coatings Technology, v. 357, p. 36-47. 0257-8972 http://hdl.handle.net/11449/188160 10.1016/j.surfcoat.2018.09.038 2-s2.0-85054450538 1353862414532005 0000-0002-7734-4069 |
url |
http://dx.doi.org/10.1016/j.surfcoat.2018.09.038 http://hdl.handle.net/11449/188160 |
identifier_str_mv |
Surface and Coatings Technology, v. 357, p. 36-47. 0257-8972 10.1016/j.surfcoat.2018.09.038 2-s2.0-85054450538 1353862414532005 0000-0002-7734-4069 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Surface and Coatings Technology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
36-47 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964652046647296 |