Comparison of urinary protein-to-creatinine ration, serum albumin, serum creatinine and systolic arterial blood pressure of glomerular injury cases in dogs with chronic kidney disease

Detalhes bibliográficos
Autor(a) principal: Sant'Anna, Paula Bilbau [UNESP]
Data de Publicação: 2021
Outros Autores: Da Silva Trindade, Fabricio, Geraldes, Silvano Salgueiro [UNESP], De Azevedo, Maria Gabriela Picelli [UNESP], Hataka, Alessandre [UNESP], Paes, Antonio Carlos [UNESP], Melchert, Alessandra [UNESP], Guimaraes-Okamoto, Priscylla Tatiana Chalfun [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.5433/1679-0359.2021v42n4p2339
http://hdl.handle.net/11449/207783
Resumo: This study aims at assessing the prevalence of glomerular alterations in dogs with chronic kidney disease (CKD) and comparing the clinical and laboratory parameters. The tests conducted include a double-blind histopathological assay conducted by two pathologists, urine tests including inactive sediment, urinary protein-to-creatinine (UPC), serum albumin and serum creatinine, as well as measurement of the systolic arterial blood pressure. The prevalence of glomerular injuries was determined and the predominant injury was compared with a group comprised of the remaining injuries. The study included 24 dogs with CKD. The results revealed a predominance of membranous glomerular alterations 17/24 (70, 83%), followed by glomerulosclerosis 3/24 (12, 50%), membranoproliferative injuries 2/24, glomerulocystic atrophy 1/24 and glomerular amyloidosis 1/24. Amyloidosis presented the highest UPC while the membranoproliferative injury presented the lowest mean concentration of serum albumin. Higher values in the UPC did not correspond with lower mean serum albumin values. Glomerulosclerosis presented the highest mean systolic blood pressure and glomerular atrophy presented the highest creatinine values. When comparing membranous injuries with a group comprised of the remaining injuries, the UPC did not present significant differences between the groups. Renal amyloidosis was included in the group with the lowest systolic arterial blood pressure values while membranoproliferative injury was included in the group with highest UPC. The group called others presented the highest creatinine value. Dogs with CKD may present several types of glomerular injuries with similar clinical and laboratory profiles. This study observed a predominance of membranous glomerular injuries, followed by membranoproliferative injuries, glomerulocystic atrophy and amyloidosis.
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spelling Comparison of urinary protein-to-creatinine ration, serum albumin, serum creatinine and systolic arterial blood pressure of glomerular injury cases in dogs with chronic kidney diseaseAmyloidosisDogsGlomerulocysticGlomerulopathyGlomerulusThis study aims at assessing the prevalence of glomerular alterations in dogs with chronic kidney disease (CKD) and comparing the clinical and laboratory parameters. The tests conducted include a double-blind histopathological assay conducted by two pathologists, urine tests including inactive sediment, urinary protein-to-creatinine (UPC), serum albumin and serum creatinine, as well as measurement of the systolic arterial blood pressure. The prevalence of glomerular injuries was determined and the predominant injury was compared with a group comprised of the remaining injuries. The study included 24 dogs with CKD. The results revealed a predominance of membranous glomerular alterations 17/24 (70, 83%), followed by glomerulosclerosis 3/24 (12, 50%), membranoproliferative injuries 2/24, glomerulocystic atrophy 1/24 and glomerular amyloidosis 1/24. Amyloidosis presented the highest UPC while the membranoproliferative injury presented the lowest mean concentration of serum albumin. Higher values in the UPC did not correspond with lower mean serum albumin values. Glomerulosclerosis presented the highest mean systolic blood pressure and glomerular atrophy presented the highest creatinine values. When comparing membranous injuries with a group comprised of the remaining injuries, the UPC did not present significant differences between the groups. Renal amyloidosis was included in the group with the lowest systolic arterial blood pressure values while membranoproliferative injury was included in the group with highest UPC. The group called others presented the highest creatinine value. Dogs with CKD may present several types of glomerular injuries with similar clinical and laboratory profiles. This study observed a predominance of membranous glomerular injuries, followed by membranoproliferative injuries, glomerulocystic atrophy and amyloidosis.Veterinary Medicine Program in School of Veterinary Medicine and Animal Sciences Universidade Estadual de São Paulo UNESPVeterinary PathologistDepatment of Veterinary Clinic in School of Veterinary Medicine and Animal Sciences UNESPDepatment of Vet. Hygiene and Public Health in School of Veterinary Medicine and Animal Science UNESPVeterinary Medicine Program in School of Veterinary Medicine and Animal Sciences Universidade Estadual de São Paulo UNESPDepatment of Veterinary Clinic in School of Veterinary Medicine and Animal Sciences UNESPDepatment of Vet. Hygiene and Public Health in School of Veterinary Medicine and Animal Science UNESPUniversidade Estadual Paulista (Unesp)Veterinary PathologistSant'Anna, Paula Bilbau [UNESP]Da Silva Trindade, FabricioGeraldes, Silvano Salgueiro [UNESP]De Azevedo, Maria Gabriela Picelli [UNESP]Hataka, Alessandre [UNESP]Paes, Antonio Carlos [UNESP]Melchert, Alessandra [UNESP]Guimaraes-Okamoto, Priscylla Tatiana Chalfun [UNESP]2021-06-25T11:00:56Z2021-06-25T11:00:56Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2339-2358http://dx.doi.org/10.5433/1679-0359.2021v42n4p2339Semina:Ciencias Agrarias, v. 42, n. 4, p. 2339-2358, 2021.1679-03591676-546Xhttp://hdl.handle.net/11449/20778310.5433/1679-0359.2021v42n4p23392-s2.0-85106613738Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengSemina:Ciencias Agrariasinfo:eu-repo/semantics/openAccess2024-09-03T14:12:03Zoai:repositorio.unesp.br:11449/207783Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T14:12:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Comparison of urinary protein-to-creatinine ration, serum albumin, serum creatinine and systolic arterial blood pressure of glomerular injury cases in dogs with chronic kidney disease
title Comparison of urinary protein-to-creatinine ration, serum albumin, serum creatinine and systolic arterial blood pressure of glomerular injury cases in dogs with chronic kidney disease
spellingShingle Comparison of urinary protein-to-creatinine ration, serum albumin, serum creatinine and systolic arterial blood pressure of glomerular injury cases in dogs with chronic kidney disease
Sant'Anna, Paula Bilbau [UNESP]
Amyloidosis
Dogs
Glomerulocystic
Glomerulopathy
Glomerulus
title_short Comparison of urinary protein-to-creatinine ration, serum albumin, serum creatinine and systolic arterial blood pressure of glomerular injury cases in dogs with chronic kidney disease
title_full Comparison of urinary protein-to-creatinine ration, serum albumin, serum creatinine and systolic arterial blood pressure of glomerular injury cases in dogs with chronic kidney disease
title_fullStr Comparison of urinary protein-to-creatinine ration, serum albumin, serum creatinine and systolic arterial blood pressure of glomerular injury cases in dogs with chronic kidney disease
title_full_unstemmed Comparison of urinary protein-to-creatinine ration, serum albumin, serum creatinine and systolic arterial blood pressure of glomerular injury cases in dogs with chronic kidney disease
title_sort Comparison of urinary protein-to-creatinine ration, serum albumin, serum creatinine and systolic arterial blood pressure of glomerular injury cases in dogs with chronic kidney disease
author Sant'Anna, Paula Bilbau [UNESP]
author_facet Sant'Anna, Paula Bilbau [UNESP]
Da Silva Trindade, Fabricio
Geraldes, Silvano Salgueiro [UNESP]
De Azevedo, Maria Gabriela Picelli [UNESP]
Hataka, Alessandre [UNESP]
Paes, Antonio Carlos [UNESP]
Melchert, Alessandra [UNESP]
Guimaraes-Okamoto, Priscylla Tatiana Chalfun [UNESP]
author_role author
author2 Da Silva Trindade, Fabricio
Geraldes, Silvano Salgueiro [UNESP]
De Azevedo, Maria Gabriela Picelli [UNESP]
Hataka, Alessandre [UNESP]
Paes, Antonio Carlos [UNESP]
Melchert, Alessandra [UNESP]
Guimaraes-Okamoto, Priscylla Tatiana Chalfun [UNESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Veterinary Pathologist
dc.contributor.author.fl_str_mv Sant'Anna, Paula Bilbau [UNESP]
Da Silva Trindade, Fabricio
Geraldes, Silvano Salgueiro [UNESP]
De Azevedo, Maria Gabriela Picelli [UNESP]
Hataka, Alessandre [UNESP]
Paes, Antonio Carlos [UNESP]
Melchert, Alessandra [UNESP]
Guimaraes-Okamoto, Priscylla Tatiana Chalfun [UNESP]
dc.subject.por.fl_str_mv Amyloidosis
Dogs
Glomerulocystic
Glomerulopathy
Glomerulus
topic Amyloidosis
Dogs
Glomerulocystic
Glomerulopathy
Glomerulus
description This study aims at assessing the prevalence of glomerular alterations in dogs with chronic kidney disease (CKD) and comparing the clinical and laboratory parameters. The tests conducted include a double-blind histopathological assay conducted by two pathologists, urine tests including inactive sediment, urinary protein-to-creatinine (UPC), serum albumin and serum creatinine, as well as measurement of the systolic arterial blood pressure. The prevalence of glomerular injuries was determined and the predominant injury was compared with a group comprised of the remaining injuries. The study included 24 dogs with CKD. The results revealed a predominance of membranous glomerular alterations 17/24 (70, 83%), followed by glomerulosclerosis 3/24 (12, 50%), membranoproliferative injuries 2/24, glomerulocystic atrophy 1/24 and glomerular amyloidosis 1/24. Amyloidosis presented the highest UPC while the membranoproliferative injury presented the lowest mean concentration of serum albumin. Higher values in the UPC did not correspond with lower mean serum albumin values. Glomerulosclerosis presented the highest mean systolic blood pressure and glomerular atrophy presented the highest creatinine values. When comparing membranous injuries with a group comprised of the remaining injuries, the UPC did not present significant differences between the groups. Renal amyloidosis was included in the group with the lowest systolic arterial blood pressure values while membranoproliferative injury was included in the group with highest UPC. The group called others presented the highest creatinine value. Dogs with CKD may present several types of glomerular injuries with similar clinical and laboratory profiles. This study observed a predominance of membranous glomerular injuries, followed by membranoproliferative injuries, glomerulocystic atrophy and amyloidosis.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T11:00:56Z
2021-06-25T11:00:56Z
2021-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5433/1679-0359.2021v42n4p2339
Semina:Ciencias Agrarias, v. 42, n. 4, p. 2339-2358, 2021.
1679-0359
1676-546X
http://hdl.handle.net/11449/207783
10.5433/1679-0359.2021v42n4p2339
2-s2.0-85106613738
url http://dx.doi.org/10.5433/1679-0359.2021v42n4p2339
http://hdl.handle.net/11449/207783
identifier_str_mv Semina:Ciencias Agrarias, v. 42, n. 4, p. 2339-2358, 2021.
1679-0359
1676-546X
10.5433/1679-0359.2021v42n4p2339
2-s2.0-85106613738
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Semina:Ciencias Agrarias
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2339-2358
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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