Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.3922/j.psns.2014.02.04 http://hdl.handle.net/11449/114956 |
Resumo: | A magnitude comparison deficit has been frequently observed in velocardiofacial syndrome (Del22q11.2). We hypothesized that this deficit extends to impairments in the acuity of the approximate number system (ANS). Three groups of children aged 8-14 years were investigated: Del22q11.2 children (n = 12), low cognitive ability children (LCA; n = 12), and matched typicallydeveloping children (TD; n = 28). All children were assessed with a simple reaction time task and symbolic and nonsymbolic number comparison tasks. To estimate the acuity of the ANS, the Weber fraction (w) was calculated from the nonsymbolic comparison task. The Del22q11.2 group exhibited a significantly higher w compared with the other groups. Importantly, no significant differences were found in w between the TD and LCA groups. The performance pattern of the Del22q11.2 group was similar to the TD group in the symbolic comparison task, and both of these groups had better performance than the LCA group. The impairment of ANS acuity observed in individuals with Del22q11.2 cannot be explained by deficits in general processing speed because no significant group differences were found in the simple reaction time task. These results suggest that lower acuity of the ANS should be added to the behavioral phenotype of Del22q11.2. The absence of impaired ANS acuity in the LCA group is consistent with the hypothesis that number sense is a relatively specific and autonomous domain. Investigations of low ANS acuity in mathematics learning difficulties and Del22q11.2 should be intensified. |
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Impaired acuity of the approximate number system in 22q11.2 microdeletion syndromesíndrome del22q11.2fenótipoaprendizagemA magnitude comparison deficit has been frequently observed in velocardiofacial syndrome (Del22q11.2). We hypothesized that this deficit extends to impairments in the acuity of the approximate number system (ANS). Three groups of children aged 8-14 years were investigated: Del22q11.2 children (n = 12), low cognitive ability children (LCA; n = 12), and matched typicallydeveloping children (TD; n = 28). All children were assessed with a simple reaction time task and symbolic and nonsymbolic number comparison tasks. To estimate the acuity of the ANS, the Weber fraction (w) was calculated from the nonsymbolic comparison task. The Del22q11.2 group exhibited a significantly higher w compared with the other groups. Importantly, no significant differences were found in w between the TD and LCA groups. The performance pattern of the Del22q11.2 group was similar to the TD group in the symbolic comparison task, and both of these groups had better performance than the LCA group. The impairment of ANS acuity observed in individuals with Del22q11.2 cannot be explained by deficits in general processing speed because no significant group differences were found in the simple reaction time task. These results suggest that lower acuity of the ANS should be added to the behavioral phenotype of Del22q11.2. The absence of impaired ANS acuity in the LCA group is consistent with the hypothesis that number sense is a relatively specific and autonomous domain. Investigations of low ANS acuity in mathematics learning difficulties and Del22q11.2 should be intensified.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Filosofia e Ciências - Campus de Marília, Marília, Rua Hygino Muzy Filho, 737, Mirante, CEP 17525000, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Filosofia e Ciências - Campus de Marília, Marília, Rua Hygino Muzy Filho, 737, Mirante, CEP 17525000, SP, BrasilCNPq: 307006/2008-5CNPq: 401232/2009-3CNPq: 307975/2010-0FAPEMIG: APQ-02755-SHAFAPEMIG: APQ-03289-10FWF: P22577-BUniversidade Federal de Minas Gerais (UFMG)Universidade Estadual Paulista (Unesp)Pontifícia Universidade Católica de Minas Gerais (PUC Minas)Universidade de São Paulo (USP)Karl-Franzens University of GrazInstitut National de la Santé et de la Recherche Médicale (INSERM)Oliveira, LíviaSantos, Amanda [UNESP]Vianna, GabrielleDi Ninno, CamilaGiacheti, Célia Maria [UNESP]Carvalho, MariaWood, GuilhermePinheiro Chagas, PedroHaase, Vitor2015-02-24T13:57:37Z2015-02-24T13:57:37Z2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article151-158application/pdfhttp://dx.doi.org/10.3922/j.psns.2014.02.04Psychology & Neuroscience, v. 7, n. 2, p. 151-158, 2014.1984-3054http://hdl.handle.net/11449/11495610.3922/j.psns.2014.02.04ISSN19843054-2014-07-02-151-158.pdf2331180822532901Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPsychology & Neuroscience0,245info:eu-repo/semantics/openAccess2024-08-09T17:39:01Zoai:repositorio.unesp.br:11449/114956Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-09T17:39:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome |
title |
Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome |
spellingShingle |
Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome Oliveira, Lívia síndrome del22q11.2 fenótipo aprendizagem |
title_short |
Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome |
title_full |
Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome |
title_fullStr |
Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome |
title_full_unstemmed |
Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome |
title_sort |
Impaired acuity of the approximate number system in 22q11.2 microdeletion syndrome |
author |
Oliveira, Lívia |
author_facet |
Oliveira, Lívia Santos, Amanda [UNESP] Vianna, Gabrielle Di Ninno, Camila Giacheti, Célia Maria [UNESP] Carvalho, Maria Wood, Guilherme Pinheiro Chagas, Pedro Haase, Vitor |
author_role |
author |
author2 |
Santos, Amanda [UNESP] Vianna, Gabrielle Di Ninno, Camila Giacheti, Célia Maria [UNESP] Carvalho, Maria Wood, Guilherme Pinheiro Chagas, Pedro Haase, Vitor |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Minas Gerais (UFMG) Universidade Estadual Paulista (Unesp) Pontifícia Universidade Católica de Minas Gerais (PUC Minas) Universidade de São Paulo (USP) Karl-Franzens University of Graz Institut National de la Santé et de la Recherche Médicale (INSERM) |
dc.contributor.author.fl_str_mv |
Oliveira, Lívia Santos, Amanda [UNESP] Vianna, Gabrielle Di Ninno, Camila Giacheti, Célia Maria [UNESP] Carvalho, Maria Wood, Guilherme Pinheiro Chagas, Pedro Haase, Vitor |
dc.subject.por.fl_str_mv |
síndrome del22q11.2 fenótipo aprendizagem |
topic |
síndrome del22q11.2 fenótipo aprendizagem |
description |
A magnitude comparison deficit has been frequently observed in velocardiofacial syndrome (Del22q11.2). We hypothesized that this deficit extends to impairments in the acuity of the approximate number system (ANS). Three groups of children aged 8-14 years were investigated: Del22q11.2 children (n = 12), low cognitive ability children (LCA; n = 12), and matched typicallydeveloping children (TD; n = 28). All children were assessed with a simple reaction time task and symbolic and nonsymbolic number comparison tasks. To estimate the acuity of the ANS, the Weber fraction (w) was calculated from the nonsymbolic comparison task. The Del22q11.2 group exhibited a significantly higher w compared with the other groups. Importantly, no significant differences were found in w between the TD and LCA groups. The performance pattern of the Del22q11.2 group was similar to the TD group in the symbolic comparison task, and both of these groups had better performance than the LCA group. The impairment of ANS acuity observed in individuals with Del22q11.2 cannot be explained by deficits in general processing speed because no significant group differences were found in the simple reaction time task. These results suggest that lower acuity of the ANS should be added to the behavioral phenotype of Del22q11.2. The absence of impaired ANS acuity in the LCA group is consistent with the hypothesis that number sense is a relatively specific and autonomous domain. Investigations of low ANS acuity in mathematics learning difficulties and Del22q11.2 should be intensified. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2015-02-24T13:57:37Z 2015-02-24T13:57:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.3922/j.psns.2014.02.04 Psychology & Neuroscience, v. 7, n. 2, p. 151-158, 2014. 1984-3054 http://hdl.handle.net/11449/114956 10.3922/j.psns.2014.02.04 ISSN19843054-2014-07-02-151-158.pdf 2331180822532901 |
url |
http://dx.doi.org/10.3922/j.psns.2014.02.04 http://hdl.handle.net/11449/114956 |
identifier_str_mv |
Psychology & Neuroscience, v. 7, n. 2, p. 151-158, 2014. 1984-3054 10.3922/j.psns.2014.02.04 ISSN19843054-2014-07-02-151-158.pdf 2331180822532901 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Psychology & Neuroscience 0,245 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
151-158 application/pdf |
dc.source.none.fl_str_mv |
Currículo Lattes reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128119487332352 |