Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed–Sternberg Cells in 10 High-Power Fields Have Better Prognosis

Detalhes bibliográficos
Autor(a) principal: Lacet, Dominique Fonseca Rodrigues [UNESP]
Data de Publicação: 2022
Outros Autores: Oliveira, Cristiano Claudino [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s12288-021-01517-7
http://hdl.handle.net/11449/230206
Resumo: The CD20 immunoexpression in classical Hodgkin lymphoma (CHL) is variable and it may represent an intersection between the pathophysiology of CHL and the clinical prognosis of patients. Retrospective study with 174 patients with pathological diagnosis of CHL. Clinical data were reviewed from medical records. Immunophenotypic study with CD20 were performed in two ways: hotspot count and in 10 high-power fields (HPF). The data were tabulated and the p value less than 0.05 was considered significant. The CD20-positive phenotype was found in 45 (25.9%) of the total of 174 patients with available material. Patients with CD20 positivity on neoplastic cells tend to heal earlier, particularly those with less than 10.5 cells/10 HPF (p = 0.037). Patients with CHL with less than 10.5 CD20-positive Reed-Sternberg cells in 10 HPF have better prognosis.
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spelling Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed–Sternberg Cells in 10 High-Power Fields Have Better PrognosisCD20 antigenHodgkin diseaseImmunohistochemistryPatient outcome assessmentPrognosisThe CD20 immunoexpression in classical Hodgkin lymphoma (CHL) is variable and it may represent an intersection between the pathophysiology of CHL and the clinical prognosis of patients. Retrospective study with 174 patients with pathological diagnosis of CHL. Clinical data were reviewed from medical records. Immunophenotypic study with CD20 were performed in two ways: hotspot count and in 10 high-power fields (HPF). The data were tabulated and the p value less than 0.05 was considered significant. The CD20-positive phenotype was found in 45 (25.9%) of the total of 174 patients with available material. Patients with CD20 positivity on neoplastic cells tend to heal earlier, particularly those with less than 10.5 cells/10 HPF (p = 0.037). Patients with CHL with less than 10.5 CD20-positive Reed-Sternberg cells in 10 HPF have better prognosis.Department of Pathology Botucatu School of Medicine São Paulo State University (FMB UNESP)Department of Pathology Luxemburgo Hospital, Rua Gentios, 1350, Luxemburgo, Minas GeraisDepartment of Pathology São Luiz/D’Or HospitalDepartment of Pathology Botucatu School of Medicine São Paulo State University (FMB UNESP)Universidade Estadual Paulista (UNESP)Luxemburgo HospitalSão Luiz/D’Or HospitalLacet, Dominique Fonseca Rodrigues [UNESP]Oliveira, Cristiano Claudino [UNESP]2022-04-29T08:38:33Z2022-04-29T08:38:33Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s12288-021-01517-7Indian Journal of Hematology and Blood Transfusion.0974-04490971-4502http://hdl.handle.net/11449/23020610.1007/s12288-021-01517-72-s2.0-85122707828Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengIndian Journal of Hematology and Blood Transfusioninfo:eu-repo/semantics/openAccess2024-09-03T13:14:41Zoai:repositorio.unesp.br:11449/230206Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:14:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed–Sternberg Cells in 10 High-Power Fields Have Better Prognosis
title Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed–Sternberg Cells in 10 High-Power Fields Have Better Prognosis
spellingShingle Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed–Sternberg Cells in 10 High-Power Fields Have Better Prognosis
Lacet, Dominique Fonseca Rodrigues [UNESP]
CD20 antigen
Hodgkin disease
Immunohistochemistry
Patient outcome assessment
Prognosis
title_short Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed–Sternberg Cells in 10 High-Power Fields Have Better Prognosis
title_full Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed–Sternberg Cells in 10 High-Power Fields Have Better Prognosis
title_fullStr Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed–Sternberg Cells in 10 High-Power Fields Have Better Prognosis
title_full_unstemmed Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed–Sternberg Cells in 10 High-Power Fields Have Better Prognosis
title_sort Patients with Classical Hodgkin Lymphoma with Less Than 10.5 CD20-Positive Reed–Sternberg Cells in 10 High-Power Fields Have Better Prognosis
author Lacet, Dominique Fonseca Rodrigues [UNESP]
author_facet Lacet, Dominique Fonseca Rodrigues [UNESP]
Oliveira, Cristiano Claudino [UNESP]
author_role author
author2 Oliveira, Cristiano Claudino [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Luxemburgo Hospital
São Luiz/D’Or Hospital
dc.contributor.author.fl_str_mv Lacet, Dominique Fonseca Rodrigues [UNESP]
Oliveira, Cristiano Claudino [UNESP]
dc.subject.por.fl_str_mv CD20 antigen
Hodgkin disease
Immunohistochemistry
Patient outcome assessment
Prognosis
topic CD20 antigen
Hodgkin disease
Immunohistochemistry
Patient outcome assessment
Prognosis
description The CD20 immunoexpression in classical Hodgkin lymphoma (CHL) is variable and it may represent an intersection between the pathophysiology of CHL and the clinical prognosis of patients. Retrospective study with 174 patients with pathological diagnosis of CHL. Clinical data were reviewed from medical records. Immunophenotypic study with CD20 were performed in two ways: hotspot count and in 10 high-power fields (HPF). The data were tabulated and the p value less than 0.05 was considered significant. The CD20-positive phenotype was found in 45 (25.9%) of the total of 174 patients with available material. Patients with CD20 positivity on neoplastic cells tend to heal earlier, particularly those with less than 10.5 cells/10 HPF (p = 0.037). Patients with CHL with less than 10.5 CD20-positive Reed-Sternberg cells in 10 HPF have better prognosis.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-29T08:38:33Z
2022-04-29T08:38:33Z
2022-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s12288-021-01517-7
Indian Journal of Hematology and Blood Transfusion.
0974-0449
0971-4502
http://hdl.handle.net/11449/230206
10.1007/s12288-021-01517-7
2-s2.0-85122707828
url http://dx.doi.org/10.1007/s12288-021-01517-7
http://hdl.handle.net/11449/230206
identifier_str_mv Indian Journal of Hematology and Blood Transfusion.
0974-0449
0971-4502
10.1007/s12288-021-01517-7
2-s2.0-85122707828
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Indian Journal of Hematology and Blood Transfusion
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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