Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00210-016-1296-5 http://hdl.handle.net/11449/173463 |
Resumo: | Sodium hydrosulfide (NaHS) has presented antihypertensive and antioxidant effects and may reduce circulating soluble fms-like tyrosine kinase-1 (sFlt-1). We examined whether NaHS prevents maternal and fetal detrimental changes in a model of hypertension in pregnancy induced by N(G)-nitro-L-arginine methyl ester (L-NAME). Forty pregnant rats were divided into four groups (n = 10 per group): Norm-Preg, Preg + NaHS, HTN-Preg, or HTN-Preg + NaHS. Systolic blood pressure (SBP), number of viable fetuses, litter size, pups, and placentae weights were recorded. Circulating plasma sFlt-1, vascular endothelial growth factor (VEGF), myeloperoxidase (MPO), trolox equivalent antioxidant capacity (TEAC) levels, and biochemical determinants of nitric oxide (NO) formation were assessed. SBP values were elevated in the HTN-Preg group on gestational days 16, 18, and 20. However, HTN-Preg + NaHS group presented lower SBP values on days 18 and 20. Lower number of viable fetuses and litter size were found only in HTN-Preg group compared to other. Reductions in placental weight were found in HTN-Preg and HTN-Preg + NaHS groups. Increases in fetal weight were found only in Preg + NaHS group. Increases in circulating sFlt-1 and VEGF levels were observed only in HTN-Preg group compared to other. Higher MPO and lower TEAC plasma levels were found in HTN-Preg + NaHS and HTN-Preg groups. NO was diminished in HTN-Preg animals, and NaHS treatment increased NO levels only in hypertensive pregnant animals. Treatment with NaHS prevents hypertension in pregnancy and concomitantly reduces circulating plasma sFlt-1 and VEGF levels; this correlates with improved litter size with more viable fetuses and increase in NO levels. However, these beneficial effects presented no relation with oxidative stress. |
id |
UNSP_51651407b0b73eb0f8e1de8fc5ac8dad |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/173463 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant ratsHydrogen sulfide donorN(G)-nitro-L-arginine methyl esterPreeclampsiaRatsSodium hydrosulfide (NaHS) has presented antihypertensive and antioxidant effects and may reduce circulating soluble fms-like tyrosine kinase-1 (sFlt-1). We examined whether NaHS prevents maternal and fetal detrimental changes in a model of hypertension in pregnancy induced by N(G)-nitro-L-arginine methyl ester (L-NAME). Forty pregnant rats were divided into four groups (n = 10 per group): Norm-Preg, Preg + NaHS, HTN-Preg, or HTN-Preg + NaHS. Systolic blood pressure (SBP), number of viable fetuses, litter size, pups, and placentae weights were recorded. Circulating plasma sFlt-1, vascular endothelial growth factor (VEGF), myeloperoxidase (MPO), trolox equivalent antioxidant capacity (TEAC) levels, and biochemical determinants of nitric oxide (NO) formation were assessed. SBP values were elevated in the HTN-Preg group on gestational days 16, 18, and 20. However, HTN-Preg + NaHS group presented lower SBP values on days 18 and 20. Lower number of viable fetuses and litter size were found only in HTN-Preg group compared to other. Reductions in placental weight were found in HTN-Preg and HTN-Preg + NaHS groups. Increases in fetal weight were found only in Preg + NaHS group. Increases in circulating sFlt-1 and VEGF levels were observed only in HTN-Preg group compared to other. Higher MPO and lower TEAC plasma levels were found in HTN-Preg + NaHS and HTN-Preg groups. NO was diminished in HTN-Preg animals, and NaHS treatment increased NO levels only in hypertensive pregnant animals. Treatment with NaHS prevents hypertension in pregnancy and concomitantly reduces circulating plasma sFlt-1 and VEGF levels; this correlates with improved litter size with more viable fetuses and increase in NO levels. However, these beneficial effects presented no relation with oxidative stress.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, 18.618-970Department of Pharmacology Biosciences Institute of Botucatu Sao Paulo State University (UNESP), Distrito de Rubiao Junior S/N, 18.618-970FAPESP: FAPESP - BrazilUniversidade Estadual Paulista (Unesp)Possomato-Vieira, Jose Sergio [UNESP]Gonçalves-Rizzi, Victor Hugo [UNESP]Graça, Tamiris Uracs Sales [UNESP]Nascimento, Regina Aparecida [UNESP]Dias-Junior, Carlos A. [UNESP]2018-12-11T17:05:37Z2018-12-11T17:05:37Z2016-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1325-1332application/pdfhttp://dx.doi.org/10.1007/s00210-016-1296-5Naunyn-Schmiedeberg's Archives of Pharmacology, v. 389, n. 12, p. 1325-1332, 2016.1432-19120028-1298http://hdl.handle.net/11449/17346310.1007/s00210-016-1296-52-s2.0-849876070092-s2.0-84987607009.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNaunyn-Schmiedeberg's Archives of Pharmacology0,836info:eu-repo/semantics/openAccess2023-10-23T06:10:17Zoai:repositorio.unesp.br:11449/173463Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-23T06:10:17Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats |
title |
Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats |
spellingShingle |
Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats Possomato-Vieira, Jose Sergio [UNESP] Hydrogen sulfide donor N(G)-nitro-L-arginine methyl ester Preeclampsia Rats |
title_short |
Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats |
title_full |
Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats |
title_fullStr |
Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats |
title_full_unstemmed |
Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats |
title_sort |
Sodium hydrosulfide prevents hypertension and increases in vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 in hypertensive pregnant rats |
author |
Possomato-Vieira, Jose Sergio [UNESP] |
author_facet |
Possomato-Vieira, Jose Sergio [UNESP] Gonçalves-Rizzi, Victor Hugo [UNESP] Graça, Tamiris Uracs Sales [UNESP] Nascimento, Regina Aparecida [UNESP] Dias-Junior, Carlos A. [UNESP] |
author_role |
author |
author2 |
Gonçalves-Rizzi, Victor Hugo [UNESP] Graça, Tamiris Uracs Sales [UNESP] Nascimento, Regina Aparecida [UNESP] Dias-Junior, Carlos A. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Possomato-Vieira, Jose Sergio [UNESP] Gonçalves-Rizzi, Victor Hugo [UNESP] Graça, Tamiris Uracs Sales [UNESP] Nascimento, Regina Aparecida [UNESP] Dias-Junior, Carlos A. [UNESP] |
dc.subject.por.fl_str_mv |
Hydrogen sulfide donor N(G)-nitro-L-arginine methyl ester Preeclampsia Rats |
topic |
Hydrogen sulfide donor N(G)-nitro-L-arginine methyl ester Preeclampsia Rats |
description |
Sodium hydrosulfide (NaHS) has presented antihypertensive and antioxidant effects and may reduce circulating soluble fms-like tyrosine kinase-1 (sFlt-1). We examined whether NaHS prevents maternal and fetal detrimental changes in a model of hypertension in pregnancy induced by N(G)-nitro-L-arginine methyl ester (L-NAME). Forty pregnant rats were divided into four groups (n = 10 per group): Norm-Preg, Preg + NaHS, HTN-Preg, or HTN-Preg + NaHS. Systolic blood pressure (SBP), number of viable fetuses, litter size, pups, and placentae weights were recorded. Circulating plasma sFlt-1, vascular endothelial growth factor (VEGF), myeloperoxidase (MPO), trolox equivalent antioxidant capacity (TEAC) levels, and biochemical determinants of nitric oxide (NO) formation were assessed. SBP values were elevated in the HTN-Preg group on gestational days 16, 18, and 20. However, HTN-Preg + NaHS group presented lower SBP values on days 18 and 20. Lower number of viable fetuses and litter size were found only in HTN-Preg group compared to other. Reductions in placental weight were found in HTN-Preg and HTN-Preg + NaHS groups. Increases in fetal weight were found only in Preg + NaHS group. Increases in circulating sFlt-1 and VEGF levels were observed only in HTN-Preg group compared to other. Higher MPO and lower TEAC plasma levels were found in HTN-Preg + NaHS and HTN-Preg groups. NO was diminished in HTN-Preg animals, and NaHS treatment increased NO levels only in hypertensive pregnant animals. Treatment with NaHS prevents hypertension in pregnancy and concomitantly reduces circulating plasma sFlt-1 and VEGF levels; this correlates with improved litter size with more viable fetuses and increase in NO levels. However, these beneficial effects presented no relation with oxidative stress. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-12-01 2018-12-11T17:05:37Z 2018-12-11T17:05:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00210-016-1296-5 Naunyn-Schmiedeberg's Archives of Pharmacology, v. 389, n. 12, p. 1325-1332, 2016. 1432-1912 0028-1298 http://hdl.handle.net/11449/173463 10.1007/s00210-016-1296-5 2-s2.0-84987607009 2-s2.0-84987607009.pdf |
url |
http://dx.doi.org/10.1007/s00210-016-1296-5 http://hdl.handle.net/11449/173463 |
identifier_str_mv |
Naunyn-Schmiedeberg's Archives of Pharmacology, v. 389, n. 12, p. 1325-1332, 2016. 1432-1912 0028-1298 10.1007/s00210-016-1296-5 2-s2.0-84987607009 2-s2.0-84987607009.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Naunyn-Schmiedeberg's Archives of Pharmacology 0,836 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1325-1332 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964672080740352 |