Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.if-pan.krakow.pl/pjp/cont06.html#No4 http://www.if-pan.krakow.pl/pjp/pdf/2006/4_526.pdf http://hdl.handle.net/11449/69095 |
Resumo: | Quercetin, a typical bioflavonoid ubiquitously present in fruits and vegetables, is considered to be helpful for human health. Cisplatin (cDDP) is one of the most active cytotoxic agents in the treatment of a wide range of solid tumors. The aim of this study was to investigate the possible effect of quercetin, a bioflavonoid with antioxidant potential, on cisplatin-induced nophrotoxicity and lipid peroxidation in rats. Gavage administrations of water, propylene glycol and quercetin (50 mg/kg) were made 24 and 1 h before saline or cDDP (5 mg/kg) ip injections and were repeated daily for 2, 5 or 20 subsequent days. Rats were killed 2, 5 and 20 days after ip injections, and blood and urine samples were collected to determine plasma creatinine, urine volume and osmolality. The kidneys were removed to determine the levels of thiobarbituric acid-reactive substances (TBARS) and for histological studies. Cisplatin increased lipid peroxidation, urine volume and plasma creatinine levels and decreased urine osmolality. Treatment with quercetin attenuated these alterations. These results demonstrate the role of oxidative stress and suggest a protective effect of quercetin on cisplatin-induced nephrotoxicity in adult Wistar rats. Copyright © 2006 by Institute of Pharmacology Polish Academy of Sciences. |
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Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneysAntioxidantsCisplatinLipid peroxidationNephrotoxicityQuercetinantioxidantcisplatincreatinineflavanoidplatinilpropylene glycolquercetinsodium chloridethiobarbituric acid reactive substancewateranimal experimentanimal modelanimal tissuecomparative studycontrolled studycreatinine blood leveldrug effecthistopathologylipid peroxidationmalemultiple drug dosenephrotoxicitynonhumanoxidative stressratrat strainurine osmolalityurine volumeAnimalsAntineoplastic AgentsCreatinineFree Radical ScavengersKidneyKidney DiseasesKidney Function TestsLipid PeroxidationMaleOxidative StressRatsRats, WistarTime FactorsQuercetin, a typical bioflavonoid ubiquitously present in fruits and vegetables, is considered to be helpful for human health. Cisplatin (cDDP) is one of the most active cytotoxic agents in the treatment of a wide range of solid tumors. The aim of this study was to investigate the possible effect of quercetin, a bioflavonoid with antioxidant potential, on cisplatin-induced nophrotoxicity and lipid peroxidation in rats. Gavage administrations of water, propylene glycol and quercetin (50 mg/kg) were made 24 and 1 h before saline or cDDP (5 mg/kg) ip injections and were repeated daily for 2, 5 or 20 subsequent days. Rats were killed 2, 5 and 20 days after ip injections, and blood and urine samples were collected to determine plasma creatinine, urine volume and osmolality. The kidneys were removed to determine the levels of thiobarbituric acid-reactive substances (TBARS) and for histological studies. Cisplatin increased lipid peroxidation, urine volume and plasma creatinine levels and decreased urine osmolality. Treatment with quercetin attenuated these alterations. These results demonstrate the role of oxidative stress and suggest a protective effect of quercetin on cisplatin-induced nephrotoxicity in adult Wistar rats. Copyright © 2006 by Institute of Pharmacology Polish Academy of Sciences.Departamento de Alimentos e Nutrição Faculdade de Ciencias Farmaceuticas de Araraquara UNESP, Rod. Araraquara/Jaú, km 01, 14801-902 Araraquara SPDepartamento de Análises Clínicas Toxicológicas e Bromatológicas Faculdade de Ciencias Farmaceuticas de Ribeirão Universidade de São Paulo, Av. do Café, s/n, 14040-903 Ribeirão Preto, SPDepartamento de Patologia Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, Av. Bandeirantes, 3900, 14040-903 Ribeirão Preto, SPDepartamento de Alimentos e Nutrição Faculdade de Ciencias Farmaceuticas de Araraquara UNESP, Rod. Araraquara/Jaú, km 01, 14801-902 Araraquara SPUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Behling, Estela B. [UNESP]Sendão, Milena C. [UNESP]Francescato, Heloísa D.C.Antunes, Lusânia M.G.Costa, Roberto S.Bianchi, Maria de Lourdes P.2014-05-27T11:21:58Z2014-05-27T11:21:58Z2006-09-20info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article526-532application/pdfhttp://www.if-pan.krakow.pl/pjp/cont06.html#No4http://www.if-pan.krakow.pl/pjp/pdf/2006/4_526.pdfPharmacological Reports, v. 58, n. 4, p. 526-532, 2006.1734-1140http://hdl.handle.net/11449/69095WOS:0002419401000082-s2.0-337486635252-s2.0-33748663525.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPharmacological Reports2.7870,773info:eu-repo/semantics/openAccess2024-06-21T12:47:24Zoai:repositorio.unesp.br:11449/69095Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:42:48.867619Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys |
title |
Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys |
spellingShingle |
Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys Behling, Estela B. [UNESP] Antioxidants Cisplatin Lipid peroxidation Nephrotoxicity Quercetin antioxidant cisplatin creatinine flavanoid platinil propylene glycol quercetin sodium chloride thiobarbituric acid reactive substance water animal experiment animal model animal tissue comparative study controlled study creatinine blood level drug effect histopathology lipid peroxidation male multiple drug dose nephrotoxicity nonhuman oxidative stress rat rat strain urine osmolality urine volume Animals Antineoplastic Agents Creatinine Free Radical Scavengers Kidney Kidney Diseases Kidney Function Tests Lipid Peroxidation Male Oxidative Stress Rats Rats, Wistar Time Factors |
title_short |
Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys |
title_full |
Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys |
title_fullStr |
Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys |
title_full_unstemmed |
Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys |
title_sort |
Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys |
author |
Behling, Estela B. [UNESP] |
author_facet |
Behling, Estela B. [UNESP] Sendão, Milena C. [UNESP] Francescato, Heloísa D.C. Antunes, Lusânia M.G. Costa, Roberto S. Bianchi, Maria de Lourdes P. |
author_role |
author |
author2 |
Sendão, Milena C. [UNESP] Francescato, Heloísa D.C. Antunes, Lusânia M.G. Costa, Roberto S. Bianchi, Maria de Lourdes P. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Behling, Estela B. [UNESP] Sendão, Milena C. [UNESP] Francescato, Heloísa D.C. Antunes, Lusânia M.G. Costa, Roberto S. Bianchi, Maria de Lourdes P. |
dc.subject.por.fl_str_mv |
Antioxidants Cisplatin Lipid peroxidation Nephrotoxicity Quercetin antioxidant cisplatin creatinine flavanoid platinil propylene glycol quercetin sodium chloride thiobarbituric acid reactive substance water animal experiment animal model animal tissue comparative study controlled study creatinine blood level drug effect histopathology lipid peroxidation male multiple drug dose nephrotoxicity nonhuman oxidative stress rat rat strain urine osmolality urine volume Animals Antineoplastic Agents Creatinine Free Radical Scavengers Kidney Kidney Diseases Kidney Function Tests Lipid Peroxidation Male Oxidative Stress Rats Rats, Wistar Time Factors |
topic |
Antioxidants Cisplatin Lipid peroxidation Nephrotoxicity Quercetin antioxidant cisplatin creatinine flavanoid platinil propylene glycol quercetin sodium chloride thiobarbituric acid reactive substance water animal experiment animal model animal tissue comparative study controlled study creatinine blood level drug effect histopathology lipid peroxidation male multiple drug dose nephrotoxicity nonhuman oxidative stress rat rat strain urine osmolality urine volume Animals Antineoplastic Agents Creatinine Free Radical Scavengers Kidney Kidney Diseases Kidney Function Tests Lipid Peroxidation Male Oxidative Stress Rats Rats, Wistar Time Factors |
description |
Quercetin, a typical bioflavonoid ubiquitously present in fruits and vegetables, is considered to be helpful for human health. Cisplatin (cDDP) is one of the most active cytotoxic agents in the treatment of a wide range of solid tumors. The aim of this study was to investigate the possible effect of quercetin, a bioflavonoid with antioxidant potential, on cisplatin-induced nophrotoxicity and lipid peroxidation in rats. Gavage administrations of water, propylene glycol and quercetin (50 mg/kg) were made 24 and 1 h before saline or cDDP (5 mg/kg) ip injections and were repeated daily for 2, 5 or 20 subsequent days. Rats were killed 2, 5 and 20 days after ip injections, and blood and urine samples were collected to determine plasma creatinine, urine volume and osmolality. The kidneys were removed to determine the levels of thiobarbituric acid-reactive substances (TBARS) and for histological studies. Cisplatin increased lipid peroxidation, urine volume and plasma creatinine levels and decreased urine osmolality. Treatment with quercetin attenuated these alterations. These results demonstrate the role of oxidative stress and suggest a protective effect of quercetin on cisplatin-induced nephrotoxicity in adult Wistar rats. Copyright © 2006 by Institute of Pharmacology Polish Academy of Sciences. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-09-20 2014-05-27T11:21:58Z 2014-05-27T11:21:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.if-pan.krakow.pl/pjp/cont06.html#No4 http://www.if-pan.krakow.pl/pjp/pdf/2006/4_526.pdf Pharmacological Reports, v. 58, n. 4, p. 526-532, 2006. 1734-1140 http://hdl.handle.net/11449/69095 WOS:000241940100008 2-s2.0-33748663525 2-s2.0-33748663525.pdf |
url |
http://www.if-pan.krakow.pl/pjp/cont06.html#No4 http://www.if-pan.krakow.pl/pjp/pdf/2006/4_526.pdf http://hdl.handle.net/11449/69095 |
identifier_str_mv |
Pharmacological Reports, v. 58, n. 4, p. 526-532, 2006. 1734-1140 WOS:000241940100008 2-s2.0-33748663525 2-s2.0-33748663525.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmacological Reports 2.787 0,773 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
526-532 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129545132310528 |