Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits
Autor(a) principal: | |
---|---|
Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/224933 |
Resumo: | Purpose: To investigate the effect of bovine bone morphogenetic proteins (bBMPs) bound to hydroxyapatite plus collagen in the healing of unstable radius fractures. Methods: A transverse fracture was induced at the mid of the diaphysis in both radii on 15 Norfolk rabbits with average age of 5.5 months and 3.5kg. A mixture of bBMPs bound to thin powdered hydroxyapatite (bBMP-HA) and bovine collagen as agglutinant was applied to the right radius fracture site. The left radius fracture was considered control and no treatment was used. After 30, 60 and 90 days (5 rabbits/period) the rabbits were euthanized and the radii were collected for histological analysis. Results: The descriptive histological analysis revealed that repair was similar for both forelimbs. The histomorphometric analysis showed that the mean area of newly formed bone was 867442.16 mm2, 938743.00 mm2 and 779621.06 mm2 for the control forelimbs, and 841118.47 mm2, 788038.76mm2 and 618587.24 mm2 for the treated forelimbs at 30, 60 and 90 days, respectively. Thus the newly formed bone area was 12.17% larger in the forelimbs treated with bBMP-HA/collagen than in the control forelimbs (p<0.05, Tukey test) in the 60-day period after surgery. In both forelimbs the newly formed bone area increased throughout the experimental period until the complete fracture healing. Conclusion: Based on the result obtained here we concluded that bBMP-HA/collagen induced a lower but significant improvement in fracture consolidation. |
id |
UNSP_51e95933101506efbf16980b1662af98 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/224933 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbitsBone morphogenetic proteinsFracture healingRabbitsPurpose: To investigate the effect of bovine bone morphogenetic proteins (bBMPs) bound to hydroxyapatite plus collagen in the healing of unstable radius fractures. Methods: A transverse fracture was induced at the mid of the diaphysis in both radii on 15 Norfolk rabbits with average age of 5.5 months and 3.5kg. A mixture of bBMPs bound to thin powdered hydroxyapatite (bBMP-HA) and bovine collagen as agglutinant was applied to the right radius fracture site. The left radius fracture was considered control and no treatment was used. After 30, 60 and 90 days (5 rabbits/period) the rabbits were euthanized and the radii were collected for histological analysis. Results: The descriptive histological analysis revealed that repair was similar for both forelimbs. The histomorphometric analysis showed that the mean area of newly formed bone was 867442.16 mm2, 938743.00 mm2 and 779621.06 mm2 for the control forelimbs, and 841118.47 mm2, 788038.76mm2 and 618587.24 mm2 for the treated forelimbs at 30, 60 and 90 days, respectively. Thus the newly formed bone area was 12.17% larger in the forelimbs treated with bBMP-HA/collagen than in the control forelimbs (p<0.05, Tukey test) in the 60-day period after surgery. In both forelimbs the newly formed bone area increased throughout the experimental period until the complete fracture healing. Conclusion: Based on the result obtained here we concluded that bBMP-HA/collagen induced a lower but significant improvement in fracture consolidation.School of Veterinary Medicine and Animal Science Department of Veterinary Surgery and Anesthesiology UNESP, Botucatu, São PauloDepartment of Orthopedic Science Faculty of Medicine UNESP, Botucatu, São PauloDepartment of Cellular and Molecular Biology Biology Institute Federal Fluminense University, Rio de JaneiroDepartment of Histology and Embryology Faculty of Dentistry of Bauru São Paulo University (USP), Bauru, São PauloSao Paulo State University (UNESP) Department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science, Rubião Júnior, s/n, 18618-000 Botucatu - SPSchool of Veterinary Medicine and Animal Science Department of Veterinary Surgery and Anesthesiology UNESP, Botucatu, São PauloDepartment of Orthopedic Science Faculty of Medicine UNESP, Botucatu, São PauloSao Paulo State University (UNESP) Department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science, Rubião Júnior, s/n, 18618-000 Botucatu - SPUniversidade Estadual Paulista (UNESP)Federal Fluminense UniversityUniversidade de São Paulo (USP)Lima, Alfredo Feio Da Maia [UNESP]Rahal, Sheila Canevese [UNESP]Volpi, Reinaldo Dos Santos [UNESP]Granjeiro, José MauroTaga, RumioCestari, Tania Maria2022-04-28T20:17:52Z2022-04-28T20:17:52Z2007-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject259-264Acta Cirurgica Brasileira, v. 22, n. 4, p. 259-264, 2007.0102-86501678-2674http://hdl.handle.net/11449/2249332-s2.0-34447298338Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccess2024-08-14T14:20:04Zoai:repositorio.unesp.br:11449/224933Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T14:20:04Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits |
title |
Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits |
spellingShingle |
Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits Lima, Alfredo Feio Da Maia [UNESP] Bone morphogenetic proteins Fracture healing Rabbits |
title_short |
Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits |
title_full |
Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits |
title_fullStr |
Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits |
title_full_unstemmed |
Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits |
title_sort |
Effect of bovine bone morphogenetic proteins on radius fracture healing in rabbits |
author |
Lima, Alfredo Feio Da Maia [UNESP] |
author_facet |
Lima, Alfredo Feio Da Maia [UNESP] Rahal, Sheila Canevese [UNESP] Volpi, Reinaldo Dos Santos [UNESP] Granjeiro, José Mauro Taga, Rumio Cestari, Tania Maria |
author_role |
author |
author2 |
Rahal, Sheila Canevese [UNESP] Volpi, Reinaldo Dos Santos [UNESP] Granjeiro, José Mauro Taga, Rumio Cestari, Tania Maria |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Federal Fluminense University Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Lima, Alfredo Feio Da Maia [UNESP] Rahal, Sheila Canevese [UNESP] Volpi, Reinaldo Dos Santos [UNESP] Granjeiro, José Mauro Taga, Rumio Cestari, Tania Maria |
dc.subject.por.fl_str_mv |
Bone morphogenetic proteins Fracture healing Rabbits |
topic |
Bone morphogenetic proteins Fracture healing Rabbits |
description |
Purpose: To investigate the effect of bovine bone morphogenetic proteins (bBMPs) bound to hydroxyapatite plus collagen in the healing of unstable radius fractures. Methods: A transverse fracture was induced at the mid of the diaphysis in both radii on 15 Norfolk rabbits with average age of 5.5 months and 3.5kg. A mixture of bBMPs bound to thin powdered hydroxyapatite (bBMP-HA) and bovine collagen as agglutinant was applied to the right radius fracture site. The left radius fracture was considered control and no treatment was used. After 30, 60 and 90 days (5 rabbits/period) the rabbits were euthanized and the radii were collected for histological analysis. Results: The descriptive histological analysis revealed that repair was similar for both forelimbs. The histomorphometric analysis showed that the mean area of newly formed bone was 867442.16 mm2, 938743.00 mm2 and 779621.06 mm2 for the control forelimbs, and 841118.47 mm2, 788038.76mm2 and 618587.24 mm2 for the treated forelimbs at 30, 60 and 90 days, respectively. Thus the newly formed bone area was 12.17% larger in the forelimbs treated with bBMP-HA/collagen than in the control forelimbs (p<0.05, Tukey test) in the 60-day period after surgery. In both forelimbs the newly formed bone area increased throughout the experimental period until the complete fracture healing. Conclusion: Based on the result obtained here we concluded that bBMP-HA/collagen induced a lower but significant improvement in fracture consolidation. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-07-01 2022-04-28T20:17:52Z 2022-04-28T20:17:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Acta Cirurgica Brasileira, v. 22, n. 4, p. 259-264, 2007. 0102-8650 1678-2674 http://hdl.handle.net/11449/224933 2-s2.0-34447298338 |
identifier_str_mv |
Acta Cirurgica Brasileira, v. 22, n. 4, p. 259-264, 2007. 0102-8650 1678-2674 2-s2.0-34447298338 |
url |
http://hdl.handle.net/11449/224933 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
259-264 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128139515133952 |