Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.tox.2018.10.005 http://hdl.handle.net/11449/185065 |
Resumo: | Triclosan (TCS) is a phenolic compound with antimicrobial action widely used in cosmetics and other personal care products and other industry segments. Its widespread use over the decades has made TCS one of the most commonly detected compounds in wastewater and effluent worldwide already being found in human urine, plasma and milk. In this study, the (anti)estrogenicity of TCS was evaluated in the uterotrophic assay in 18-day old female Wistar rats. In a second protocol, female rats were evaluated for the reproductive effects of TCS in a two-generation reproduction toxicity study. Female rats were daily treated by gavage with TCS at the doses of 0.8, 2.4 and 8.0 mg/kg/day or corn oil (control group) over 10 weeks (F0) and over 14 weeks (F1) prior to mating and then throughout mating, gestation and lactation until weaning of F1 and F2 generation respectively. TCS had no effect on the uterus weight in the uterotrophic assay. In the two-generation study, the TCS exposure compromised female sexual behavior, decreased maternal food consumption and increased pup grooming on TCS 2.4 group. The TCS chronic exposure also decreased the perimetrium thickness of F0 females from TCS 8.0 group and growing follicle number of TCS 2.4 females from F1 generation. Despite the some specific changes detected in the two-generation study, no impairment was observed in the uterotrophic assay and other important reproductive endpoints. In a weight of evidence evaluation, the results suggest that exposure to TCS at low doses did not act as an endocrine disruptor in the female rat reproductive system. |
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Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation studyEndocrine disruptorsReproductionBehaviorFertilityTriclosan (TCS) is a phenolic compound with antimicrobial action widely used in cosmetics and other personal care products and other industry segments. Its widespread use over the decades has made TCS one of the most commonly detected compounds in wastewater and effluent worldwide already being found in human urine, plasma and milk. In this study, the (anti)estrogenicity of TCS was evaluated in the uterotrophic assay in 18-day old female Wistar rats. In a second protocol, female rats were evaluated for the reproductive effects of TCS in a two-generation reproduction toxicity study. Female rats were daily treated by gavage with TCS at the doses of 0.8, 2.4 and 8.0 mg/kg/day or corn oil (control group) over 10 weeks (F0) and over 14 weeks (F1) prior to mating and then throughout mating, gestation and lactation until weaning of F1 and F2 generation respectively. TCS had no effect on the uterus weight in the uterotrophic assay. In the two-generation study, the TCS exposure compromised female sexual behavior, decreased maternal food consumption and increased pup grooming on TCS 2.4 group. The TCS chronic exposure also decreased the perimetrium thickness of F0 females from TCS 8.0 group and growing follicle number of TCS 2.4 females from F1 generation. Despite the some specific changes detected in the two-generation study, no impairment was observed in the uterotrophic assay and other important reproductive endpoints. In a weight of evidence evaluation, the results suggest that exposure to TCS at low doses did not act as an endocrine disruptor in the female rat reproductive system.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Estadual Londrina, Dept Physiol Sci, BR-86051980 Londrina, Parana, BrazilUniv Sao Paulo, Dept Morphol Estomatol & Physiol, BR-14040900 Ribeirao Preto, SP, BrazilSao Paulo State Univ, Dept Physiol, Botucatu Biosci Inst, BR-18618970 Botucatu, SP, BrazilSao Paulo State Univ, Dept Physiol, Botucatu Biosci Inst, BR-18618970 Botucatu, SP, BrazilCNPq: 454499/2014-0Elsevier B.V.Universidade Estadual de Londrina (UEL)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Montagnini, Bruno GarciaPernoncine, Karine VandressaBorges, Lorena IrenoCosta, Nathalia OrlandiniMoreira, Estefania GastadelloAnselmo-Franci, Janete AparecidaInhasz Kiss, Ana Carolina [UNESP]Ceccatto Gerardin, Daniela Cristina2019-10-04T12:32:20Z2019-10-04T12:32:20Z2018-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article152-165http://dx.doi.org/10.1016/j.tox.2018.10.005Toxicology. Clare: Elsevier Ireland Ltd, v. 410, p. 152-165, 2018.0300-483Xhttp://hdl.handle.net/11449/18506510.1016/j.tox.2018.10.005WOS:000450375900017Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengToxicologyinfo:eu-repo/semantics/openAccess2021-10-23T05:43:27Zoai:repositorio.unesp.br:11449/185065Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T05:43:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study |
title |
Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study |
spellingShingle |
Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study Montagnini, Bruno Garcia Endocrine disruptors Reproduction Behavior Fertility |
title_short |
Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study |
title_full |
Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study |
title_fullStr |
Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study |
title_full_unstemmed |
Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study |
title_sort |
Investigation of the potential effects of triclosan as an endocrine disruptor in female rats: Uterotrophic assay and two-generation study |
author |
Montagnini, Bruno Garcia |
author_facet |
Montagnini, Bruno Garcia Pernoncine, Karine Vandressa Borges, Lorena Ireno Costa, Nathalia Orlandini Moreira, Estefania Gastadello Anselmo-Franci, Janete Aparecida Inhasz Kiss, Ana Carolina [UNESP] Ceccatto Gerardin, Daniela Cristina |
author_role |
author |
author2 |
Pernoncine, Karine Vandressa Borges, Lorena Ireno Costa, Nathalia Orlandini Moreira, Estefania Gastadello Anselmo-Franci, Janete Aparecida Inhasz Kiss, Ana Carolina [UNESP] Ceccatto Gerardin, Daniela Cristina |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Londrina (UEL) Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Montagnini, Bruno Garcia Pernoncine, Karine Vandressa Borges, Lorena Ireno Costa, Nathalia Orlandini Moreira, Estefania Gastadello Anselmo-Franci, Janete Aparecida Inhasz Kiss, Ana Carolina [UNESP] Ceccatto Gerardin, Daniela Cristina |
dc.subject.por.fl_str_mv |
Endocrine disruptors Reproduction Behavior Fertility |
topic |
Endocrine disruptors Reproduction Behavior Fertility |
description |
Triclosan (TCS) is a phenolic compound with antimicrobial action widely used in cosmetics and other personal care products and other industry segments. Its widespread use over the decades has made TCS one of the most commonly detected compounds in wastewater and effluent worldwide already being found in human urine, plasma and milk. In this study, the (anti)estrogenicity of TCS was evaluated in the uterotrophic assay in 18-day old female Wistar rats. In a second protocol, female rats were evaluated for the reproductive effects of TCS in a two-generation reproduction toxicity study. Female rats were daily treated by gavage with TCS at the doses of 0.8, 2.4 and 8.0 mg/kg/day or corn oil (control group) over 10 weeks (F0) and over 14 weeks (F1) prior to mating and then throughout mating, gestation and lactation until weaning of F1 and F2 generation respectively. TCS had no effect on the uterus weight in the uterotrophic assay. In the two-generation study, the TCS exposure compromised female sexual behavior, decreased maternal food consumption and increased pup grooming on TCS 2.4 group. The TCS chronic exposure also decreased the perimetrium thickness of F0 females from TCS 8.0 group and growing follicle number of TCS 2.4 females from F1 generation. Despite the some specific changes detected in the two-generation study, no impairment was observed in the uterotrophic assay and other important reproductive endpoints. In a weight of evidence evaluation, the results suggest that exposure to TCS at low doses did not act as an endocrine disruptor in the female rat reproductive system. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-01 2019-10-04T12:32:20Z 2019-10-04T12:32:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.tox.2018.10.005 Toxicology. Clare: Elsevier Ireland Ltd, v. 410, p. 152-165, 2018. 0300-483X http://hdl.handle.net/11449/185065 10.1016/j.tox.2018.10.005 WOS:000450375900017 |
url |
http://dx.doi.org/10.1016/j.tox.2018.10.005 http://hdl.handle.net/11449/185065 |
identifier_str_mv |
Toxicology. Clare: Elsevier Ireland Ltd, v. 410, p. 152-165, 2018. 0300-483X 10.1016/j.tox.2018.10.005 WOS:000450375900017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Toxicology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
152-165 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803047344387653632 |