Urinary fluoride output in children following the use of a dual-fluoride varnish formulation

• Autor(a) principal: Olympio, Kelly Polido Kaneshiro
• Data de Publicação: 2009
• Outros Autores: Da Silva Cardoso, Vanessa Eid, Borro Bijella, Maria Fernanda, Pessan, Juliano Pelim [UNESP], Botazzo Delbem, Alberto Carlos [UNESP], Rabelo Buzalaf, Marília Afonso
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/S1678-77572009000300009; http://hdl.handle.net/11449/225532
• topic: Children; Fluorine; Urine. Toxicity; Varnishes

objective: This study evaluated the bioavailability of fluoride after topical application of a dual-fluoride varnish commercially available in Brazil, when compared to DuraphatTM. Material and methods: The urinary fluoride output was evaluated in seven 5- year-old children after application of the fluoride varnishes, in two different phases. In the first phase (I), children received topical application of the fluoride varnish Duofluorid XII (2.92% fluorine, calcium fluoride + 2.71% fluorine, sodium fluoride, FGM TM). After 1-month interval (phase II), the same amount (0.2 mL) of the fluoride varnish Duraphat (2.26% fluorine, sodium fluoride, Colgate TM) was applied. Before each application all the volunteers brushed their teeth with placebo dentifrice for 7 days. Urinary collections were carried out 24 h prior up to 48 h after the applications. Fluoride intake from the diet was also estimated. Fluoride concentration in diet samples and urine was analyzed with the fluoride ion-specific electrode and a miniature calomel reference electrode coupled to a potentiometer. Data were tested by ANOVA and Tukey's post hoc test (p<0.05). Results: There were significant differences in the urinary fluoride output between phases I and II. The use of Duofluorid XII did not significantly increase the urinary fluoride output, when compared to baseline levels. The application of Duraphat caused a transitory increase in the urinary fluoride output, returning to baseline levels 48 h after its use. Conclusions: The tested varnish formulation, which has been shown to be effective in in vitro studies, also can be considered safe.