Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/218604 |
Resumo: | Sympathetic activity, arteriolar structure, and angiogenesis are important mechanisms modulating hypertension and this study aimed to analyze the effects of perindopril treatment, associated or not with exercise training, on the mechanisms that control blood pressure (BP) in hypertensive rats. Spontaneously hypertensive rats (SHR) were allocated into 4 groups: 1/sedentary (S); 2/perindopril (P, 3.0 mg/kg/d); 3/trained (T); and 4/trained + perindopril (TP). Wistar rats were used as normotensive sedentary control group. SHR were assigned to undergo a treadmill training (T) or were kept sedentary. Heart rate, BP, sympathetic activity to the vessels (LF-SBP), and skeletal muscle and myocardial morphometric analyses were performed. BP was significantly lower after all 3 strategies, compared with S and was accompanied by lower LF-SBP (-76%, -53%, and -44%, for P, T, and TP, respectively). Arteriolar vessel wall cross-sectional area was lower after treatments (-56%, -52%, and -56%, for P, T, and TP, respectively), and only TP presented higher arteriolar lumen area. Capillary rarefaction was present in soleus muscle and myocardium in S group and both trained groups presented higher vessel density, although perindopril attenuated this increase in soleus muscle. Although myocyte diameter was not different between groups, myocardial collagen deposition area, higher in S group, was lower after 3 strategies. In conclusion, we may suggest that perindopril could be an option for the hypertensive people who practice exercise and need a specific pharmacological treatment to reach a better BP control, mainly because training-induced angiogenesis is an important response to facilitate blood flow perfusion and oxygen uptake and perindopril did not attenuate this response. |
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Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive RatsACE inhibitorsphysical traininghypertensionSympathetic activity, arteriolar structure, and angiogenesis are important mechanisms modulating hypertension and this study aimed to analyze the effects of perindopril treatment, associated or not with exercise training, on the mechanisms that control blood pressure (BP) in hypertensive rats. Spontaneously hypertensive rats (SHR) were allocated into 4 groups: 1/sedentary (S); 2/perindopril (P, 3.0 mg/kg/d); 3/trained (T); and 4/trained + perindopril (TP). Wistar rats were used as normotensive sedentary control group. SHR were assigned to undergo a treadmill training (T) or were kept sedentary. Heart rate, BP, sympathetic activity to the vessels (LF-SBP), and skeletal muscle and myocardial morphometric analyses were performed. BP was significantly lower after all 3 strategies, compared with S and was accompanied by lower LF-SBP (-76%, -53%, and -44%, for P, T, and TP, respectively). Arteriolar vessel wall cross-sectional area was lower after treatments (-56%, -52%, and -56%, for P, T, and TP, respectively), and only TP presented higher arteriolar lumen area. Capillary rarefaction was present in soleus muscle and myocardium in S group and both trained groups presented higher vessel density, although perindopril attenuated this increase in soleus muscle. Although myocyte diameter was not different between groups, myocardial collagen deposition area, higher in S group, was lower after 3 strategies. In conclusion, we may suggest that perindopril could be an option for the hypertensive people who practice exercise and need a specific pharmacological treatment to reach a better BP control, mainly because training-induced angiogenesis is an important response to facilitate blood flow perfusion and oxygen uptake and perindopril did not attenuate this response.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)PIPGCF UFSCar UNESP, Joint Grad Program Physiol Sci, Sao Carlos, SP, BrazilInst Biosci Humanities & Exact Sci UNESP, Sch Sci, Dept Biol, Sao Jose Do Rio Preto, SP, BrazilUNESP, Sch Sci, Dept Biol Sci, Bauru, SP, BrazilUNESP, Sch Sci, Dept Phys Educ, Bauru, SP, BrazilPIPGCF UFSCar UNESP, Joint Grad Program Physiol Sci, Sao Carlos, SP, BrazilInst Biosci Humanities & Exact Sci UNESP, Sch Sci, Dept Biol, Sao Jose Do Rio Preto, SP, BrazilUNESP, Sch Sci, Dept Biol Sci, Bauru, SP, BrazilUNESP, Sch Sci, Dept Phys Educ, Bauru, SP, BrazilFAPESP: 2017/00509-1CAPES: 001CAPES: 1692103CAPES: 88882.426908/2019-01FAPESP: 2017/14405-3Lippincott Williams & WilkinsUniversidade Estadual Paulista (UNESP)Miotto, Danyelle S. [UNESP]Duchatsch, Francine [UNESP]Macedo, Anderson G. [UNESP]Ruiz, Thalles F. R. [UNESP]Vicentini, Carlos A. [UNESP]Amaral, Sandra L. [UNESP]2022-04-28T17:21:56Z2022-04-28T17:21:56Z2021-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article519-528Journal Of Cardiovascular Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 77, n. 4, p. 519-528, 2021.0160-2446http://hdl.handle.net/11449/218604WOS:000658820600013Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Cardiovascular Pharmacologyinfo:eu-repo/semantics/openAccess2024-04-24T18:53:42Zoai:repositorio.unesp.br:11449/218604Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:27:52.889473Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats |
title |
Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats |
spellingShingle |
Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats Miotto, Danyelle S. [UNESP] ACE inhibitors physical training hypertension |
title_short |
Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats |
title_full |
Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats |
title_fullStr |
Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats |
title_full_unstemmed |
Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats |
title_sort |
Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats |
author |
Miotto, Danyelle S. [UNESP] |
author_facet |
Miotto, Danyelle S. [UNESP] Duchatsch, Francine [UNESP] Macedo, Anderson G. [UNESP] Ruiz, Thalles F. R. [UNESP] Vicentini, Carlos A. [UNESP] Amaral, Sandra L. [UNESP] |
author_role |
author |
author2 |
Duchatsch, Francine [UNESP] Macedo, Anderson G. [UNESP] Ruiz, Thalles F. R. [UNESP] Vicentini, Carlos A. [UNESP] Amaral, Sandra L. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Miotto, Danyelle S. [UNESP] Duchatsch, Francine [UNESP] Macedo, Anderson G. [UNESP] Ruiz, Thalles F. R. [UNESP] Vicentini, Carlos A. [UNESP] Amaral, Sandra L. [UNESP] |
dc.subject.por.fl_str_mv |
ACE inhibitors physical training hypertension |
topic |
ACE inhibitors physical training hypertension |
description |
Sympathetic activity, arteriolar structure, and angiogenesis are important mechanisms modulating hypertension and this study aimed to analyze the effects of perindopril treatment, associated or not with exercise training, on the mechanisms that control blood pressure (BP) in hypertensive rats. Spontaneously hypertensive rats (SHR) were allocated into 4 groups: 1/sedentary (S); 2/perindopril (P, 3.0 mg/kg/d); 3/trained (T); and 4/trained + perindopril (TP). Wistar rats were used as normotensive sedentary control group. SHR were assigned to undergo a treadmill training (T) or were kept sedentary. Heart rate, BP, sympathetic activity to the vessels (LF-SBP), and skeletal muscle and myocardial morphometric analyses were performed. BP was significantly lower after all 3 strategies, compared with S and was accompanied by lower LF-SBP (-76%, -53%, and -44%, for P, T, and TP, respectively). Arteriolar vessel wall cross-sectional area was lower after treatments (-56%, -52%, and -56%, for P, T, and TP, respectively), and only TP presented higher arteriolar lumen area. Capillary rarefaction was present in soleus muscle and myocardium in S group and both trained groups presented higher vessel density, although perindopril attenuated this increase in soleus muscle. Although myocyte diameter was not different between groups, myocardial collagen deposition area, higher in S group, was lower after 3 strategies. In conclusion, we may suggest that perindopril could be an option for the hypertensive people who practice exercise and need a specific pharmacological treatment to reach a better BP control, mainly because training-induced angiogenesis is an important response to facilitate blood flow perfusion and oxygen uptake and perindopril did not attenuate this response. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-01 2022-04-28T17:21:56Z 2022-04-28T17:21:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Journal Of Cardiovascular Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 77, n. 4, p. 519-528, 2021. 0160-2446 http://hdl.handle.net/11449/218604 WOS:000658820600013 |
identifier_str_mv |
Journal Of Cardiovascular Pharmacology. Philadelphia: Lippincott Williams & Wilkins, v. 77, n. 4, p. 519-528, 2021. 0160-2446 WOS:000658820600013 |
url |
http://hdl.handle.net/11449/218604 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Cardiovascular Pharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
519-528 |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129523453001728 |