Biodiversidade: fonte potencial para a descoberta de fármacos
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
DOI: | 10.1590/S0100-40422009000300012 |
Texto Completo: | http://dx.doi.org/10.1590/S0100-40422009000300012 http://hdl.handle.net/11449/26002 |
Resumo: | In economic terms, biodiversity transcends the boundaries usually given to conventional industries because it is a valuable source of biological and chemical data of great use to drug discovery. Certainly, the use of natural products has been the single most successful strategy in the discovery of novel medicines, and most of the medical breakthroughs are based on natural products. Half of the top 20 best-selling drugs are natural products, and their total sales amounted to US$ 16 billions shows the importance of natural products, which is evidenced by the new chemical entities (NCE) approved by regulatory authorities around the world in the past decade. Recently, the approval of the alkaloid galanthamine as a medicine to treat Alzheimer's disease shows that natural compounds from plants will continue to reach the market. The huge biological diversity of the Brazilian biomes, by its ability to generate new knowledge and technological innovation can be a fantastic alternative as raw material for drug discovery. |
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Biodiversidade: fonte potencial para a descoberta de fármacosBiodiversity: potential source for drug discoverybiodiversitynatural productsdrugsmedicinal chemistryIn economic terms, biodiversity transcends the boundaries usually given to conventional industries because it is a valuable source of biological and chemical data of great use to drug discovery. Certainly, the use of natural products has been the single most successful strategy in the discovery of novel medicines, and most of the medical breakthroughs are based on natural products. Half of the top 20 best-selling drugs are natural products, and their total sales amounted to US$ 16 billions shows the importance of natural products, which is evidenced by the new chemical entities (NCE) approved by regulatory authorities around the world in the past decade. Recently, the approval of the alkaloid galanthamine as a medicine to treat Alzheimer's disease shows that natural compounds from plants will continue to reach the market. The huge biological diversity of the Brazilian biomes, by its ability to generate new knowledge and technological innovation can be a fantastic alternative as raw material for drug discovery.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed Rio de Janeiro, Dept Farmacos, Fac Farm, Ctr Ciencias Saude, BR-21944910 Rio de Janeiro, BrazilUniversidade Estadual Paulista Instituto de Química, BR-14800900 Araraquara, SP, BrazilUniversidade Estadual Paulista Instituto de Química, BR-14800900 Araraquara, SP, BrazilSociedade Brasileira de QuímicaUniversidade Federal do Rio de Janeiro (UFRJ)Universidade Estadual Paulista (Unesp)Barreiro, Eliezer J.Bolzani, Vanderlan da Silva [UNESP]2014-05-20T14:20:00Z2014-05-20T14:20:00Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article679-688application/pdfhttp://dx.doi.org/10.1590/S0100-40422009000300012Química Nova. Sociedade Brasileira de Química, v. 32, n. 3, p. 679-688, 2009.0100-4042http://hdl.handle.net/11449/2600210.1590/S0100-40422009000300012S0100-40422009000300012WOS:000266551600012S0100-40422009000300012.pdf4484083685251673SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporQuímica Nova0.6460,255info:eu-repo/semantics/openAccess2023-12-29T06:17:43Zoai:repositorio.unesp.br:11449/26002Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:34:41.916208Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Biodiversidade: fonte potencial para a descoberta de fármacos Biodiversity: potential source for drug discovery |
title |
Biodiversidade: fonte potencial para a descoberta de fármacos |
spellingShingle |
Biodiversidade: fonte potencial para a descoberta de fármacos Biodiversidade: fonte potencial para a descoberta de fármacos Barreiro, Eliezer J. biodiversity natural products drugs medicinal chemistry Barreiro, Eliezer J. biodiversity natural products drugs medicinal chemistry |
title_short |
Biodiversidade: fonte potencial para a descoberta de fármacos |
title_full |
Biodiversidade: fonte potencial para a descoberta de fármacos |
title_fullStr |
Biodiversidade: fonte potencial para a descoberta de fármacos Biodiversidade: fonte potencial para a descoberta de fármacos |
title_full_unstemmed |
Biodiversidade: fonte potencial para a descoberta de fármacos Biodiversidade: fonte potencial para a descoberta de fármacos |
title_sort |
Biodiversidade: fonte potencial para a descoberta de fármacos |
author |
Barreiro, Eliezer J. |
author_facet |
Barreiro, Eliezer J. Barreiro, Eliezer J. Bolzani, Vanderlan da Silva [UNESP] Bolzani, Vanderlan da Silva [UNESP] |
author_role |
author |
author2 |
Bolzani, Vanderlan da Silva [UNESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Rio de Janeiro (UFRJ) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Barreiro, Eliezer J. Bolzani, Vanderlan da Silva [UNESP] |
dc.subject.por.fl_str_mv |
biodiversity natural products drugs medicinal chemistry |
topic |
biodiversity natural products drugs medicinal chemistry |
description |
In economic terms, biodiversity transcends the boundaries usually given to conventional industries because it is a valuable source of biological and chemical data of great use to drug discovery. Certainly, the use of natural products has been the single most successful strategy in the discovery of novel medicines, and most of the medical breakthroughs are based on natural products. Half of the top 20 best-selling drugs are natural products, and their total sales amounted to US$ 16 billions shows the importance of natural products, which is evidenced by the new chemical entities (NCE) approved by regulatory authorities around the world in the past decade. Recently, the approval of the alkaloid galanthamine as a medicine to treat Alzheimer's disease shows that natural compounds from plants will continue to reach the market. The huge biological diversity of the Brazilian biomes, by its ability to generate new knowledge and technological innovation can be a fantastic alternative as raw material for drug discovery. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 2014-05-20T14:20:00Z 2014-05-20T14:20:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-40422009000300012 Química Nova. Sociedade Brasileira de Química, v. 32, n. 3, p. 679-688, 2009. 0100-4042 http://hdl.handle.net/11449/26002 10.1590/S0100-40422009000300012 S0100-40422009000300012 WOS:000266551600012 S0100-40422009000300012.pdf 4484083685251673 |
url |
http://dx.doi.org/10.1590/S0100-40422009000300012 http://hdl.handle.net/11449/26002 |
identifier_str_mv |
Química Nova. Sociedade Brasileira de Química, v. 32, n. 3, p. 679-688, 2009. 0100-4042 10.1590/S0100-40422009000300012 S0100-40422009000300012 WOS:000266551600012 S0100-40422009000300012.pdf 4484083685251673 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Química Nova 0.646 0,255 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
679-688 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
publisher.none.fl_str_mv |
Sociedade Brasileira de Química |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1822218413891649536 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-40422009000300012 |