Biodiversidade: fonte potencial para a descoberta de fármacos

Detalhes bibliográficos
Autor(a) principal: Barreiro, Eliezer J.
Data de Publicação: 2009
Outros Autores: Bolzani, Vanderlan da Silva [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
DOI: 10.1590/S0100-40422009000300012
Texto Completo: http://dx.doi.org/10.1590/S0100-40422009000300012
http://hdl.handle.net/11449/26002
Resumo: In economic terms, biodiversity transcends the boundaries usually given to conventional industries because it is a valuable source of biological and chemical data of great use to drug discovery. Certainly, the use of natural products has been the single most successful strategy in the discovery of novel medicines, and most of the medical breakthroughs are based on natural products. Half of the top 20 best-selling drugs are natural products, and their total sales amounted to US$ 16 billions shows the importance of natural products, which is evidenced by the new chemical entities (NCE) approved by regulatory authorities around the world in the past decade. Recently, the approval of the alkaloid galanthamine as a medicine to treat Alzheimer's disease shows that natural compounds from plants will continue to reach the market. The huge biological diversity of the Brazilian biomes, by its ability to generate new knowledge and technological innovation can be a fantastic alternative as raw material for drug discovery.
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spelling Biodiversidade: fonte potencial para a descoberta de fármacosBiodiversity: potential source for drug discoverybiodiversitynatural productsdrugsmedicinal chemistryIn economic terms, biodiversity transcends the boundaries usually given to conventional industries because it is a valuable source of biological and chemical data of great use to drug discovery. Certainly, the use of natural products has been the single most successful strategy in the discovery of novel medicines, and most of the medical breakthroughs are based on natural products. Half of the top 20 best-selling drugs are natural products, and their total sales amounted to US$ 16 billions shows the importance of natural products, which is evidenced by the new chemical entities (NCE) approved by regulatory authorities around the world in the past decade. Recently, the approval of the alkaloid galanthamine as a medicine to treat Alzheimer's disease shows that natural compounds from plants will continue to reach the market. The huge biological diversity of the Brazilian biomes, by its ability to generate new knowledge and technological innovation can be a fantastic alternative as raw material for drug discovery.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Fed Rio de Janeiro, Dept Farmacos, Fac Farm, Ctr Ciencias Saude, BR-21944910 Rio de Janeiro, BrazilUniversidade Estadual Paulista Instituto de Química, BR-14800900 Araraquara, SP, BrazilUniversidade Estadual Paulista Instituto de Química, BR-14800900 Araraquara, SP, BrazilSociedade Brasileira de QuímicaUniversidade Federal do Rio de Janeiro (UFRJ)Universidade Estadual Paulista (Unesp)Barreiro, Eliezer J.Bolzani, Vanderlan da Silva [UNESP]2014-05-20T14:20:00Z2014-05-20T14:20:00Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article679-688application/pdfhttp://dx.doi.org/10.1590/S0100-40422009000300012Química Nova. Sociedade Brasileira de Química, v. 32, n. 3, p. 679-688, 2009.0100-4042http://hdl.handle.net/11449/2600210.1590/S0100-40422009000300012S0100-40422009000300012WOS:000266551600012S0100-40422009000300012.pdf4484083685251673SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporQuímica Nova0.6460,255info:eu-repo/semantics/openAccess2023-12-29T06:17:43Zoai:repositorio.unesp.br:11449/26002Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:34:41.916208Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Biodiversidade: fonte potencial para a descoberta de fármacos
Biodiversity: potential source for drug discovery
title Biodiversidade: fonte potencial para a descoberta de fármacos
spellingShingle Biodiversidade: fonte potencial para a descoberta de fármacos
Biodiversidade: fonte potencial para a descoberta de fármacos
Barreiro, Eliezer J.
biodiversity
natural products
drugs
medicinal chemistry
Barreiro, Eliezer J.
biodiversity
natural products
drugs
medicinal chemistry
title_short Biodiversidade: fonte potencial para a descoberta de fármacos
title_full Biodiversidade: fonte potencial para a descoberta de fármacos
title_fullStr Biodiversidade: fonte potencial para a descoberta de fármacos
Biodiversidade: fonte potencial para a descoberta de fármacos
title_full_unstemmed Biodiversidade: fonte potencial para a descoberta de fármacos
Biodiversidade: fonte potencial para a descoberta de fármacos
title_sort Biodiversidade: fonte potencial para a descoberta de fármacos
author Barreiro, Eliezer J.
author_facet Barreiro, Eliezer J.
Barreiro, Eliezer J.
Bolzani, Vanderlan da Silva [UNESP]
Bolzani, Vanderlan da Silva [UNESP]
author_role author
author2 Bolzani, Vanderlan da Silva [UNESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Barreiro, Eliezer J.
Bolzani, Vanderlan da Silva [UNESP]
dc.subject.por.fl_str_mv biodiversity
natural products
drugs
medicinal chemistry
topic biodiversity
natural products
drugs
medicinal chemistry
description In economic terms, biodiversity transcends the boundaries usually given to conventional industries because it is a valuable source of biological and chemical data of great use to drug discovery. Certainly, the use of natural products has been the single most successful strategy in the discovery of novel medicines, and most of the medical breakthroughs are based on natural products. Half of the top 20 best-selling drugs are natural products, and their total sales amounted to US$ 16 billions shows the importance of natural products, which is evidenced by the new chemical entities (NCE) approved by regulatory authorities around the world in the past decade. Recently, the approval of the alkaloid galanthamine as a medicine to treat Alzheimer's disease shows that natural compounds from plants will continue to reach the market. The huge biological diversity of the Brazilian biomes, by its ability to generate new knowledge and technological innovation can be a fantastic alternative as raw material for drug discovery.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
2014-05-20T14:20:00Z
2014-05-20T14:20:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-40422009000300012
Química Nova. Sociedade Brasileira de Química, v. 32, n. 3, p. 679-688, 2009.
0100-4042
http://hdl.handle.net/11449/26002
10.1590/S0100-40422009000300012
S0100-40422009000300012
WOS:000266551600012
S0100-40422009000300012.pdf
4484083685251673
url http://dx.doi.org/10.1590/S0100-40422009000300012
http://hdl.handle.net/11449/26002
identifier_str_mv Química Nova. Sociedade Brasileira de Química, v. 32, n. 3, p. 679-688, 2009.
0100-4042
10.1590/S0100-40422009000300012
S0100-40422009000300012
WOS:000266551600012
S0100-40422009000300012.pdf
4484083685251673
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Química Nova
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0,255
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 679-688
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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dc.identifier.doi.none.fl_str_mv 10.1590/S0100-40422009000300012