Biodiversidade: fonte potencial para a descoberta de fármacos

• Autor(a) principal: Barreiro, Eliezer J.
• Data de Publicação: 2009
• Outros Autores: Bolzani, Vanderlan da Silva [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• DOI: 10.1590/S0100-40422009000300012
• Texto Completo: http://dx.doi.org/10.1590/S0100-40422009000300012; http://hdl.handle.net/11449/26002
• topic: biodiversity; natural products; drugs; medicinal chemistry

In economic terms, biodiversity transcends the boundaries usually given to conventional industries because it is a valuable source of biological and chemical data of great use to drug discovery. Certainly, the use of natural products has been the single most successful strategy in the discovery of novel medicines, and most of the medical breakthroughs are based on natural products. Half of the top 20 best-selling drugs are natural products, and their total sales amounted to US$ 16 billions shows the importance of natural products, which is evidenced by the new chemical entities (NCE) approved by regulatory authorities around the world in the past decade. Recently, the approval of the alkaloid galanthamine as a medicine to treat Alzheimer's disease shows that natural compounds from plants will continue to reach the market. The huge biological diversity of the Brazilian biomes, by its ability to generate new knowledge and technological innovation can be a fantastic alternative as raw material for drug discovery.