Osseointegration of Ti-30Ta implants without primary stability: Effect of tranexamic acid
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4028/www.scientific.net/MSF.869.918 http://hdl.handle.net/11449/178284 |
Resumo: | A large clot formed between the inside of the bony wall of the extraction socket and the immediate implant surface may have premature breakdown. Tranexamic acid (TXA) is fibrinolysis inhibitor and an analog of the amino acid lysine. In this paper the influence of tranexamic acid on the osseointegration of Ti-30Ta implants without primary stability was investigated. Were fabricated 32 implants of CP Titanium Grade 4 and 32 implants of Ti-30Ta alloy with dimensions of 2.1 × 2.8mm Ø. Bone defects of 2.5×3.2 mm Ø were created in right tibia of 64 Wistar male-rats using a small round bur. They were divided (n=16) into: Group I (CP-Ti machined implant), Group II (CP-Ti machined implant/ tranexamic acid), Group III (Ti-30Ta implant) and Group IV (Ti-30Ta implant/ tranexamic acid). The surgical defects of the Group II and Group IV were bathed with 20 ml of the tranexamic acid solution. The animals were euthanized at 45 days postoperative. In the right tibia of half each group (8 animals/8 tibiae) the maximum torque value necessary for manual removal of each implant was measured in Newton centimeters (Ncm). The right tibia of other half each group was subjected to non-decalcified histology processing (Stevenel's blue/Alizarin red). Data were analyzed statistically (Kruskal-Wallis Analyses) and demonstrated significant differences (P<0.05) among groups. The values of group I were significantly lower than group III and IV, but without significant difference than group II both removal torque and peri-implant bone healing. The results suggest that: a) peri-implant bone formation occurred more rapidly around the Ti-30Ta implant; b) tranexamic acid favored the stabilization of blood clot and bone formation around Ti- 30Ta implants and not influenced bone formation around Ti-CP implants. |
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Osseointegration of Ti-30Ta implants without primary stability: Effect of tranexamic acidAlloysTantalumTitaniumTranexamic acidWound healingA large clot formed between the inside of the bony wall of the extraction socket and the immediate implant surface may have premature breakdown. Tranexamic acid (TXA) is fibrinolysis inhibitor and an analog of the amino acid lysine. In this paper the influence of tranexamic acid on the osseointegration of Ti-30Ta implants without primary stability was investigated. Were fabricated 32 implants of CP Titanium Grade 4 and 32 implants of Ti-30Ta alloy with dimensions of 2.1 × 2.8mm Ø. Bone defects of 2.5×3.2 mm Ø were created in right tibia of 64 Wistar male-rats using a small round bur. They were divided (n=16) into: Group I (CP-Ti machined implant), Group II (CP-Ti machined implant/ tranexamic acid), Group III (Ti-30Ta implant) and Group IV (Ti-30Ta implant/ tranexamic acid). The surgical defects of the Group II and Group IV were bathed with 20 ml of the tranexamic acid solution. The animals were euthanized at 45 days postoperative. In the right tibia of half each group (8 animals/8 tibiae) the maximum torque value necessary for manual removal of each implant was measured in Newton centimeters (Ncm). The right tibia of other half each group was subjected to non-decalcified histology processing (Stevenel's blue/Alizarin red). Data were analyzed statistically (Kruskal-Wallis Analyses) and demonstrated significant differences (P<0.05) among groups. The values of group I were significantly lower than group III and IV, but without significant difference than group II both removal torque and peri-implant bone healing. The results suggest that: a) peri-implant bone formation occurred more rapidly around the Ti-30Ta implant; b) tranexamic acid favored the stabilization of blood clot and bone formation around Ti- 30Ta implants and not influenced bone formation around Ti-CP implants.Faculdade de Odontologia de Araçatuba Universidade Estadual Paulista ‘Júlio de Mesquita Filho’ UNESPFaculdade de Medicina Veterinária de Araçatuba Universidade Estadual Paulista ‘Júlio de Mesquita Filho’ UNESPFaculdade de Engenharia de Guaratinguetá Universidade Estadual Paulista ‘Júlio de Mesquita Filho’ UNESPFaculdade de Ciências de Bauru Universidade Estadual Paulista ‘Júlio de Mesquita Filho’ UNESPUniversidade Estadual Paulista ‘Júlio de Mesquita Filho’ UNESPFaculdade de Odontologia de Araçatuba Universidade Estadual Paulista ‘Júlio de Mesquita Filho’ UNESPFaculdade de Medicina Veterinária de Araçatuba Universidade Estadual Paulista ‘Júlio de Mesquita Filho’ UNESPFaculdade de Engenharia de Guaratinguetá Universidade Estadual Paulista ‘Júlio de Mesquita Filho’ UNESPFaculdade de Ciências de Bauru Universidade Estadual Paulista ‘Júlio de Mesquita Filho’ UNESPUniversidade Estadual Paulista ‘Júlio de Mesquita Filho’ UNESPUniversidade Estadual Paulista (Unesp)Rosifini Alves Rezende, Maria Cristina [UNESP]Capalbo, Bruna Cabrera [UNESP]Louzada, Mario Jefferson Quirino [UNESP]Rangel, André Luiz Reis [UNESP]Cintra, Luciano Ângelo [UNESP]de Oliveira, João Augusto Guedes [UNESP]Lisboa-Filho, Paulo Noronha [UNESP]Wada, Cristiane Mayumi [UNESP]Rosifini Alves Claro, Ana Paula [UNESP]2018-12-11T17:29:37Z2018-12-11T17:29:37Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject918-923application/pdfhttp://dx.doi.org/10.4028/www.scientific.net/MSF.869.918Materials Science Forum, v. 869, p. 918-923.0255-5476http://hdl.handle.net/11449/17828410.4028/www.scientific.net/MSF.869.9182-s2.0-849884200122-s2.0-84988420012.pdf13538624145320050000-0002-7734-4069Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMaterials Science Forum0,180info:eu-repo/semantics/openAccess2024-09-04T19:16:41Zoai:repositorio.unesp.br:11449/178284Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-04T19:16:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Osseointegration of Ti-30Ta implants without primary stability: Effect of tranexamic acid |
title |
Osseointegration of Ti-30Ta implants without primary stability: Effect of tranexamic acid |
spellingShingle |
Osseointegration of Ti-30Ta implants without primary stability: Effect of tranexamic acid Rosifini Alves Rezende, Maria Cristina [UNESP] Alloys Tantalum Titanium Tranexamic acid Wound healing |
title_short |
Osseointegration of Ti-30Ta implants without primary stability: Effect of tranexamic acid |
title_full |
Osseointegration of Ti-30Ta implants without primary stability: Effect of tranexamic acid |
title_fullStr |
Osseointegration of Ti-30Ta implants without primary stability: Effect of tranexamic acid |
title_full_unstemmed |
Osseointegration of Ti-30Ta implants without primary stability: Effect of tranexamic acid |
title_sort |
Osseointegration of Ti-30Ta implants without primary stability: Effect of tranexamic acid |
author |
Rosifini Alves Rezende, Maria Cristina [UNESP] |
author_facet |
Rosifini Alves Rezende, Maria Cristina [UNESP] Capalbo, Bruna Cabrera [UNESP] Louzada, Mario Jefferson Quirino [UNESP] Rangel, André Luiz Reis [UNESP] Cintra, Luciano Ângelo [UNESP] de Oliveira, João Augusto Guedes [UNESP] Lisboa-Filho, Paulo Noronha [UNESP] Wada, Cristiane Mayumi [UNESP] Rosifini Alves Claro, Ana Paula [UNESP] |
author_role |
author |
author2 |
Capalbo, Bruna Cabrera [UNESP] Louzada, Mario Jefferson Quirino [UNESP] Rangel, André Luiz Reis [UNESP] Cintra, Luciano Ângelo [UNESP] de Oliveira, João Augusto Guedes [UNESP] Lisboa-Filho, Paulo Noronha [UNESP] Wada, Cristiane Mayumi [UNESP] Rosifini Alves Claro, Ana Paula [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Rosifini Alves Rezende, Maria Cristina [UNESP] Capalbo, Bruna Cabrera [UNESP] Louzada, Mario Jefferson Quirino [UNESP] Rangel, André Luiz Reis [UNESP] Cintra, Luciano Ângelo [UNESP] de Oliveira, João Augusto Guedes [UNESP] Lisboa-Filho, Paulo Noronha [UNESP] Wada, Cristiane Mayumi [UNESP] Rosifini Alves Claro, Ana Paula [UNESP] |
dc.subject.por.fl_str_mv |
Alloys Tantalum Titanium Tranexamic acid Wound healing |
topic |
Alloys Tantalum Titanium Tranexamic acid Wound healing |
description |
A large clot formed between the inside of the bony wall of the extraction socket and the immediate implant surface may have premature breakdown. Tranexamic acid (TXA) is fibrinolysis inhibitor and an analog of the amino acid lysine. In this paper the influence of tranexamic acid on the osseointegration of Ti-30Ta implants without primary stability was investigated. Were fabricated 32 implants of CP Titanium Grade 4 and 32 implants of Ti-30Ta alloy with dimensions of 2.1 × 2.8mm Ø. Bone defects of 2.5×3.2 mm Ø were created in right tibia of 64 Wistar male-rats using a small round bur. They were divided (n=16) into: Group I (CP-Ti machined implant), Group II (CP-Ti machined implant/ tranexamic acid), Group III (Ti-30Ta implant) and Group IV (Ti-30Ta implant/ tranexamic acid). The surgical defects of the Group II and Group IV were bathed with 20 ml of the tranexamic acid solution. The animals were euthanized at 45 days postoperative. In the right tibia of half each group (8 animals/8 tibiae) the maximum torque value necessary for manual removal of each implant was measured in Newton centimeters (Ncm). The right tibia of other half each group was subjected to non-decalcified histology processing (Stevenel's blue/Alizarin red). Data were analyzed statistically (Kruskal-Wallis Analyses) and demonstrated significant differences (P<0.05) among groups. The values of group I were significantly lower than group III and IV, but without significant difference than group II both removal torque and peri-implant bone healing. The results suggest that: a) peri-implant bone formation occurred more rapidly around the Ti-30Ta implant; b) tranexamic acid favored the stabilization of blood clot and bone formation around Ti- 30Ta implants and not influenced bone formation around Ti-CP implants. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-01 2018-12-11T17:29:37Z 2018-12-11T17:29:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4028/www.scientific.net/MSF.869.918 Materials Science Forum, v. 869, p. 918-923. 0255-5476 http://hdl.handle.net/11449/178284 10.4028/www.scientific.net/MSF.869.918 2-s2.0-84988420012 2-s2.0-84988420012.pdf 1353862414532005 0000-0002-7734-4069 |
url |
http://dx.doi.org/10.4028/www.scientific.net/MSF.869.918 http://hdl.handle.net/11449/178284 |
identifier_str_mv |
Materials Science Forum, v. 869, p. 918-923. 0255-5476 10.4028/www.scientific.net/MSF.869.918 2-s2.0-84988420012 2-s2.0-84988420012.pdf 1353862414532005 0000-0002-7734-4069 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Materials Science Forum 0,180 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
918-923 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1810021364639203328 |