Primary pulmonary choriocarcinoma after human chorionic gonadotropin normalization following hydatidiform mole: A report of two cases
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/226054 |
Resumo: | BACKGROUND: Primary pulmonary choriocarcinoma (PPC) is rare and frequently leads to death. CASES: Two young patients presented with previous molar pregnancy and spontaneous serum human chorionic gonadotropin (hCG) normalization. Patient 1 was referred to our center after partial response to chemotherapy. Pulmonary lobectomy was performed, and hCG rapidly declined. During further chemotherapy, liver metastasis was detected by positron emission tomography. Right hepatectomy was performed, and hCG declined for 28 days, but increased again despite chemotherapy. This patient died from hepatic failure 3 years after diagnosis. Patient 2 presented with persistently high hCG, though the affected organ was not identified. Chemotherapy was unsuccessful. Patient reevaluation showed an isolated pulmonary mass. Pulmonary lobectomy was performed; 2 weeks later, hCG was normal and consolidation with 2 cycles of chemotherapy was administered. The patient has been in remission for 24 months. PPC was confirmed by histopathology and immunohistochemistry in both cases. Gestational origin of the tumor was confirmed by molecular genetic analysis (polymorphic microsatellite markers). CONCLUSION: The possibility of choriocarcinoma cannot be overlooked in young women with an isolated pulmonary mass. Early diagnosis, prompt chemotherapy, and surgical resection in a specialized center improves the prognosis. © Journal of Reproductive Medicine®, Inc. |
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Primary pulmonary choriocarcinoma after human chorionic gonadotropin normalization following hydatidiform mole: A report of two casesGenetic originPrimary pulmonary choriocarcinomaSalvage therapyBACKGROUND: Primary pulmonary choriocarcinoma (PPC) is rare and frequently leads to death. CASES: Two young patients presented with previous molar pregnancy and spontaneous serum human chorionic gonadotropin (hCG) normalization. Patient 1 was referred to our center after partial response to chemotherapy. Pulmonary lobectomy was performed, and hCG rapidly declined. During further chemotherapy, liver metastasis was detected by positron emission tomography. Right hepatectomy was performed, and hCG declined for 28 days, but increased again despite chemotherapy. This patient died from hepatic failure 3 years after diagnosis. Patient 2 presented with persistently high hCG, though the affected organ was not identified. Chemotherapy was unsuccessful. Patient reevaluation showed an isolated pulmonary mass. Pulmonary lobectomy was performed; 2 weeks later, hCG was normal and consolidation with 2 cycles of chemotherapy was administered. The patient has been in remission for 24 months. PPC was confirmed by histopathology and immunohistochemistry in both cases. Gestational origin of the tumor was confirmed by molecular genetic analysis (polymorphic microsatellite markers). CONCLUSION: The possibility of choriocarcinoma cannot be overlooked in young women with an isolated pulmonary mass. Early diagnosis, prompt chemotherapy, and surgical resection in a specialized center improves the prognosis. © Journal of Reproductive Medicine®, Inc.Trophoblastic Diseases Center of the Department of Gynecology and Obstetrics Oncological Treatment Center of the Department of Internal Medicine, and Neogene Laboratory Botucatu Medical School, São Paulo State University/ UNESP, Botucatu, São PauloTrophoblastic Diseases Center of the Department of Gynecology and Obstetrics Oncological Treatment Center of the Department of Internal Medicine, and Neogene Laboratory Botucatu Medical School, São Paulo State University/ UNESP, Botucatu, São PauloUniversidade Estadual Paulista (UNESP)Maestá, Izildinha [UNESP]Leite, Fábio Vicente [UNESP]Michelin, Odair Carlito [UNESP]Rogatto, And Silvia Regina [UNESP]2022-04-28T21:25:06Z2022-04-28T21:25:06Z2010-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article311-316Journal of Reproductive Medicine for the Obstetrician and Gynecologist, v. 55, n. 7-8, p. 311-316, 2010.0024-7758http://hdl.handle.net/11449/2260542-s2.0-77957254391Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Reproductive Medicine for the Obstetrician and Gynecologistinfo:eu-repo/semantics/openAccess2022-04-28T21:25:06Zoai:repositorio.unesp.br:11449/226054Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-28T21:25:06Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Primary pulmonary choriocarcinoma after human chorionic gonadotropin normalization following hydatidiform mole: A report of two cases |
title |
Primary pulmonary choriocarcinoma after human chorionic gonadotropin normalization following hydatidiform mole: A report of two cases |
spellingShingle |
Primary pulmonary choriocarcinoma after human chorionic gonadotropin normalization following hydatidiform mole: A report of two cases Maestá, Izildinha [UNESP] Genetic origin Primary pulmonary choriocarcinoma Salvage therapy |
title_short |
Primary pulmonary choriocarcinoma after human chorionic gonadotropin normalization following hydatidiform mole: A report of two cases |
title_full |
Primary pulmonary choriocarcinoma after human chorionic gonadotropin normalization following hydatidiform mole: A report of two cases |
title_fullStr |
Primary pulmonary choriocarcinoma after human chorionic gonadotropin normalization following hydatidiform mole: A report of two cases |
title_full_unstemmed |
Primary pulmonary choriocarcinoma after human chorionic gonadotropin normalization following hydatidiform mole: A report of two cases |
title_sort |
Primary pulmonary choriocarcinoma after human chorionic gonadotropin normalization following hydatidiform mole: A report of two cases |
author |
Maestá, Izildinha [UNESP] |
author_facet |
Maestá, Izildinha [UNESP] Leite, Fábio Vicente [UNESP] Michelin, Odair Carlito [UNESP] Rogatto, And Silvia Regina [UNESP] |
author_role |
author |
author2 |
Leite, Fábio Vicente [UNESP] Michelin, Odair Carlito [UNESP] Rogatto, And Silvia Regina [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Maestá, Izildinha [UNESP] Leite, Fábio Vicente [UNESP] Michelin, Odair Carlito [UNESP] Rogatto, And Silvia Regina [UNESP] |
dc.subject.por.fl_str_mv |
Genetic origin Primary pulmonary choriocarcinoma Salvage therapy |
topic |
Genetic origin Primary pulmonary choriocarcinoma Salvage therapy |
description |
BACKGROUND: Primary pulmonary choriocarcinoma (PPC) is rare and frequently leads to death. CASES: Two young patients presented with previous molar pregnancy and spontaneous serum human chorionic gonadotropin (hCG) normalization. Patient 1 was referred to our center after partial response to chemotherapy. Pulmonary lobectomy was performed, and hCG rapidly declined. During further chemotherapy, liver metastasis was detected by positron emission tomography. Right hepatectomy was performed, and hCG declined for 28 days, but increased again despite chemotherapy. This patient died from hepatic failure 3 years after diagnosis. Patient 2 presented with persistently high hCG, though the affected organ was not identified. Chemotherapy was unsuccessful. Patient reevaluation showed an isolated pulmonary mass. Pulmonary lobectomy was performed; 2 weeks later, hCG was normal and consolidation with 2 cycles of chemotherapy was administered. The patient has been in remission for 24 months. PPC was confirmed by histopathology and immunohistochemistry in both cases. Gestational origin of the tumor was confirmed by molecular genetic analysis (polymorphic microsatellite markers). CONCLUSION: The possibility of choriocarcinoma cannot be overlooked in young women with an isolated pulmonary mass. Early diagnosis, prompt chemotherapy, and surgical resection in a specialized center improves the prognosis. © Journal of Reproductive Medicine®, Inc. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-07-01 2022-04-28T21:25:06Z 2022-04-28T21:25:06Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Journal of Reproductive Medicine for the Obstetrician and Gynecologist, v. 55, n. 7-8, p. 311-316, 2010. 0024-7758 http://hdl.handle.net/11449/226054 2-s2.0-77957254391 |
identifier_str_mv |
Journal of Reproductive Medicine for the Obstetrician and Gynecologist, v. 55, n. 7-8, p. 311-316, 2010. 0024-7758 2-s2.0-77957254391 |
url |
http://hdl.handle.net/11449/226054 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Reproductive Medicine for the Obstetrician and Gynecologist |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
311-316 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964716177555456 |