Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil
Autor(a) principal: | |
---|---|
Data de Publicação: | 2004 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-879X2004001100016 http://hdl.handle.net/11449/13063 |
Resumo: | Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, and most people have serological evidence of previous viral infection at adult age. EBV is associated with infectious mononucleosis and human cancers, including some lymphomas and gastric carcinomas. Although EBV was first reported in lymphoepithelioma-like gastric carcinoma, the virus was also found in conventional adenocarcinomas. In the present study, 53 gastric carcinomas diagnosed in São Paulo State, Brazil, were evaluated for EBV infection by non-isotopic in situ hybridization with a biotinylated probe (Biotin-AGACACCGTCCTCACCACCC GGGACTTGTA) directed to the viral transcript EBER-I, which is actively expressed in EBV latently infected cells. EBV infection was found in 6 of 53 (11.32%) gastric carcinomas, mostly from male patients (66.7%), with a mean age of 59 years old. Most EBV-positive tumors were in gastric antrum. Two EBV-positive tumors (33.3%) were conventional adenocarcinomas, whereas four (66.7%) were classified as lymphoepithelioma-like carcinomas. EBV infection in gastric carcinomas was reported elsewhere in frequencies that range from 5.6% (Korea) up to 18% (Germany). In Brazil, a previous work found EBV infection in 4 of 80 (5%) gastric carcinomas, whereas another study found 4.7 and 11.2% of EBV-positive gastric carcinomas of Brazilians of Japanese origin or not, respectively. In the present study, the frequency of EBV-positive gastric carcinomas is similar to that reported in other series, and the clinicopathologic characteristics of these EBV-positive tumors are in agreement with the data in the literature. |
id |
UNSP_56625749a466d7620944685100b6e697 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/13063 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Epstein-Barr virus infection and gastric carcinoma in São Paulo State, BrazilEpstein-Barr virusGastric carcinomaIn situ hybridizationBrazilEpstein-Barr virus (EBV) is a ubiquitous herpesvirus, and most people have serological evidence of previous viral infection at adult age. EBV is associated with infectious mononucleosis and human cancers, including some lymphomas and gastric carcinomas. Although EBV was first reported in lymphoepithelioma-like gastric carcinoma, the virus was also found in conventional adenocarcinomas. In the present study, 53 gastric carcinomas diagnosed in São Paulo State, Brazil, were evaluated for EBV infection by non-isotopic in situ hybridization with a biotinylated probe (Biotin-AGACACCGTCCTCACCACCC GGGACTTGTA) directed to the viral transcript EBER-I, which is actively expressed in EBV latently infected cells. EBV infection was found in 6 of 53 (11.32%) gastric carcinomas, mostly from male patients (66.7%), with a mean age of 59 years old. Most EBV-positive tumors were in gastric antrum. Two EBV-positive tumors (33.3%) were conventional adenocarcinomas, whereas four (66.7%) were classified as lymphoepithelioma-like carcinomas. EBV infection in gastric carcinomas was reported elsewhere in frequencies that range from 5.6% (Korea) up to 18% (Germany). In Brazil, a previous work found EBV infection in 4 of 80 (5%) gastric carcinomas, whereas another study found 4.7 and 11.2% of EBV-positive gastric carcinomas of Brazilians of Japanese origin or not, respectively. In the present study, the frequency of EBV-positive gastric carcinomas is similar to that reported in other series, and the clinicopathologic characteristics of these EBV-positive tumors are in agreement with the data in the literature.Consultoria em PatologiaUniversidade Estadual de São Paulo Faculdade de Medicina de Botucatu Departamento de PatologiaUniversidade Estadual de Campinas Faculdade de Ciências Médicas Departamento de TocoginecologiaHospital Israelita Albert EinsteinAssociação Brasileira de Divulgação Científica (ABRADIC)Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Hospital Israelita Albert EinsteinLopes, L. F.Bacchi, Maura Moscardi [UNESP]Elgui-de-Oliveira, D. [UNESP]Zanati, S. G. [UNESP]Alvarenga, M.Bacchi, Carlos Eduardo [UNESP]2014-05-20T13:37:41Z2014-05-20T13:37:41Z2004-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1707-1712application/pdfhttp://dx.doi.org/10.1590/S0100-879X2004001100016Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 11, p. 1707-1712, 2004.0100-879Xhttp://hdl.handle.net/11449/1306310.1590/S0100-879X2004001100016S0100-879X20040011000162-s2.0-9244244298S0100-879X2004001100016.pdf0000-0001-5562-9648SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Research1.492info:eu-repo/semantics/openAccess2023-11-23T06:16:42Zoai:repositorio.unesp.br:11449/13063Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:33:00.751139Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil |
title |
Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil |
spellingShingle |
Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil Lopes, L. F. Epstein-Barr virus Gastric carcinoma In situ hybridization Brazil |
title_short |
Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil |
title_full |
Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil |
title_fullStr |
Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil |
title_full_unstemmed |
Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil |
title_sort |
Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil |
author |
Lopes, L. F. |
author_facet |
Lopes, L. F. Bacchi, Maura Moscardi [UNESP] Elgui-de-Oliveira, D. [UNESP] Zanati, S. G. [UNESP] Alvarenga, M. Bacchi, Carlos Eduardo [UNESP] |
author_role |
author |
author2 |
Bacchi, Maura Moscardi [UNESP] Elgui-de-Oliveira, D. [UNESP] Zanati, S. G. [UNESP] Alvarenga, M. Bacchi, Carlos Eduardo [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) Hospital Israelita Albert Einstein |
dc.contributor.author.fl_str_mv |
Lopes, L. F. Bacchi, Maura Moscardi [UNESP] Elgui-de-Oliveira, D. [UNESP] Zanati, S. G. [UNESP] Alvarenga, M. Bacchi, Carlos Eduardo [UNESP] |
dc.subject.por.fl_str_mv |
Epstein-Barr virus Gastric carcinoma In situ hybridization Brazil |
topic |
Epstein-Barr virus Gastric carcinoma In situ hybridization Brazil |
description |
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, and most people have serological evidence of previous viral infection at adult age. EBV is associated with infectious mononucleosis and human cancers, including some lymphomas and gastric carcinomas. Although EBV was first reported in lymphoepithelioma-like gastric carcinoma, the virus was also found in conventional adenocarcinomas. In the present study, 53 gastric carcinomas diagnosed in São Paulo State, Brazil, were evaluated for EBV infection by non-isotopic in situ hybridization with a biotinylated probe (Biotin-AGACACCGTCCTCACCACCC GGGACTTGTA) directed to the viral transcript EBER-I, which is actively expressed in EBV latently infected cells. EBV infection was found in 6 of 53 (11.32%) gastric carcinomas, mostly from male patients (66.7%), with a mean age of 59 years old. Most EBV-positive tumors were in gastric antrum. Two EBV-positive tumors (33.3%) were conventional adenocarcinomas, whereas four (66.7%) were classified as lymphoepithelioma-like carcinomas. EBV infection in gastric carcinomas was reported elsewhere in frequencies that range from 5.6% (Korea) up to 18% (Germany). In Brazil, a previous work found EBV infection in 4 of 80 (5%) gastric carcinomas, whereas another study found 4.7 and 11.2% of EBV-positive gastric carcinomas of Brazilians of Japanese origin or not, respectively. In the present study, the frequency of EBV-positive gastric carcinomas is similar to that reported in other series, and the clinicopathologic characteristics of these EBV-positive tumors are in agreement with the data in the literature. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-11-01 2014-05-20T13:37:41Z 2014-05-20T13:37:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-879X2004001100016 Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 11, p. 1707-1712, 2004. 0100-879X http://hdl.handle.net/11449/13063 10.1590/S0100-879X2004001100016 S0100-879X2004001100016 2-s2.0-9244244298 S0100-879X2004001100016.pdf 0000-0001-5562-9648 |
url |
http://dx.doi.org/10.1590/S0100-879X2004001100016 http://hdl.handle.net/11449/13063 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 11, p. 1707-1712, 2004. 0100-879X 10.1590/S0100-879X2004001100016 S0100-879X2004001100016 2-s2.0-9244244298 S0100-879X2004001100016.pdf 0000-0001-5562-9648 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research 1.492 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1707-1712 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica (ABRADIC) |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica (ABRADIC) |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128945593253888 |