Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil

Detalhes bibliográficos
Autor(a) principal: Lopes, L. F.
Data de Publicação: 2004
Outros Autores: Bacchi, Maura Moscardi [UNESP], Elgui-de-Oliveira, D. [UNESP], Zanati, S. G. [UNESP], Alvarenga, M., Bacchi, Carlos Eduardo [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S0100-879X2004001100016
http://hdl.handle.net/11449/13063
Resumo: Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, and most people have serological evidence of previous viral infection at adult age. EBV is associated with infectious mononucleosis and human cancers, including some lymphomas and gastric carcinomas. Although EBV was first reported in lymphoepithelioma-like gastric carcinoma, the virus was also found in conventional adenocarcinomas. In the present study, 53 gastric carcinomas diagnosed in São Paulo State, Brazil, were evaluated for EBV infection by non-isotopic in situ hybridization with a biotinylated probe (Biotin-AGACACCGTCCTCACCACCC GGGACTTGTA) directed to the viral transcript EBER-I, which is actively expressed in EBV latently infected cells. EBV infection was found in 6 of 53 (11.32%) gastric carcinomas, mostly from male patients (66.7%), with a mean age of 59 years old. Most EBV-positive tumors were in gastric antrum. Two EBV-positive tumors (33.3%) were conventional adenocarcinomas, whereas four (66.7%) were classified as lymphoepithelioma-like carcinomas. EBV infection in gastric carcinomas was reported elsewhere in frequencies that range from 5.6% (Korea) up to 18% (Germany). In Brazil, a previous work found EBV infection in 4 of 80 (5%) gastric carcinomas, whereas another study found 4.7 and 11.2% of EBV-positive gastric carcinomas of Brazilians of Japanese origin or not, respectively. In the present study, the frequency of EBV-positive gastric carcinomas is similar to that reported in other series, and the clinicopathologic characteristics of these EBV-positive tumors are in agreement with the data in the literature.
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spelling Epstein-Barr virus infection and gastric carcinoma in São Paulo State, BrazilEpstein-Barr virusGastric carcinomaIn situ hybridizationBrazilEpstein-Barr virus (EBV) is a ubiquitous herpesvirus, and most people have serological evidence of previous viral infection at adult age. EBV is associated with infectious mononucleosis and human cancers, including some lymphomas and gastric carcinomas. Although EBV was first reported in lymphoepithelioma-like gastric carcinoma, the virus was also found in conventional adenocarcinomas. In the present study, 53 gastric carcinomas diagnosed in São Paulo State, Brazil, were evaluated for EBV infection by non-isotopic in situ hybridization with a biotinylated probe (Biotin-AGACACCGTCCTCACCACCC GGGACTTGTA) directed to the viral transcript EBER-I, which is actively expressed in EBV latently infected cells. EBV infection was found in 6 of 53 (11.32%) gastric carcinomas, mostly from male patients (66.7%), with a mean age of 59 years old. Most EBV-positive tumors were in gastric antrum. Two EBV-positive tumors (33.3%) were conventional adenocarcinomas, whereas four (66.7%) were classified as lymphoepithelioma-like carcinomas. EBV infection in gastric carcinomas was reported elsewhere in frequencies that range from 5.6% (Korea) up to 18% (Germany). In Brazil, a previous work found EBV infection in 4 of 80 (5%) gastric carcinomas, whereas another study found 4.7 and 11.2% of EBV-positive gastric carcinomas of Brazilians of Japanese origin or not, respectively. In the present study, the frequency of EBV-positive gastric carcinomas is similar to that reported in other series, and the clinicopathologic characteristics of these EBV-positive tumors are in agreement with the data in the literature.Consultoria em PatologiaUniversidade Estadual de São Paulo Faculdade de Medicina de Botucatu Departamento de PatologiaUniversidade Estadual de Campinas Faculdade de Ciências Médicas Departamento de TocoginecologiaHospital Israelita Albert EinsteinAssociação Brasileira de Divulgação Científica (ABRADIC)Universidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Hospital Israelita Albert EinsteinLopes, L. F.Bacchi, Maura Moscardi [UNESP]Elgui-de-Oliveira, D. [UNESP]Zanati, S. G. [UNESP]Alvarenga, M.Bacchi, Carlos Eduardo [UNESP]2014-05-20T13:37:41Z2014-05-20T13:37:41Z2004-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1707-1712application/pdfhttp://dx.doi.org/10.1590/S0100-879X2004001100016Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 11, p. 1707-1712, 2004.0100-879Xhttp://hdl.handle.net/11449/1306310.1590/S0100-879X2004001100016S0100-879X20040011000162-s2.0-9244244298S0100-879X2004001100016.pdf0000-0001-5562-9648SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Medical and Biological Research1.492info:eu-repo/semantics/openAccess2023-11-23T06:16:42Zoai:repositorio.unesp.br:11449/13063Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:33:00.751139Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil
title Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil
spellingShingle Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil
Lopes, L. F.
Epstein-Barr virus
Gastric carcinoma
In situ hybridization
Brazil
title_short Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil
title_full Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil
title_fullStr Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil
title_full_unstemmed Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil
title_sort Epstein-Barr virus infection and gastric carcinoma in São Paulo State, Brazil
author Lopes, L. F.
author_facet Lopes, L. F.
Bacchi, Maura Moscardi [UNESP]
Elgui-de-Oliveira, D. [UNESP]
Zanati, S. G. [UNESP]
Alvarenga, M.
Bacchi, Carlos Eduardo [UNESP]
author_role author
author2 Bacchi, Maura Moscardi [UNESP]
Elgui-de-Oliveira, D. [UNESP]
Zanati, S. G. [UNESP]
Alvarenga, M.
Bacchi, Carlos Eduardo [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
Hospital Israelita Albert Einstein
dc.contributor.author.fl_str_mv Lopes, L. F.
Bacchi, Maura Moscardi [UNESP]
Elgui-de-Oliveira, D. [UNESP]
Zanati, S. G. [UNESP]
Alvarenga, M.
Bacchi, Carlos Eduardo [UNESP]
dc.subject.por.fl_str_mv Epstein-Barr virus
Gastric carcinoma
In situ hybridization
Brazil
topic Epstein-Barr virus
Gastric carcinoma
In situ hybridization
Brazil
description Epstein-Barr virus (EBV) is a ubiquitous herpesvirus, and most people have serological evidence of previous viral infection at adult age. EBV is associated with infectious mononucleosis and human cancers, including some lymphomas and gastric carcinomas. Although EBV was first reported in lymphoepithelioma-like gastric carcinoma, the virus was also found in conventional adenocarcinomas. In the present study, 53 gastric carcinomas diagnosed in São Paulo State, Brazil, were evaluated for EBV infection by non-isotopic in situ hybridization with a biotinylated probe (Biotin-AGACACCGTCCTCACCACCC GGGACTTGTA) directed to the viral transcript EBER-I, which is actively expressed in EBV latently infected cells. EBV infection was found in 6 of 53 (11.32%) gastric carcinomas, mostly from male patients (66.7%), with a mean age of 59 years old. Most EBV-positive tumors were in gastric antrum. Two EBV-positive tumors (33.3%) were conventional adenocarcinomas, whereas four (66.7%) were classified as lymphoepithelioma-like carcinomas. EBV infection in gastric carcinomas was reported elsewhere in frequencies that range from 5.6% (Korea) up to 18% (Germany). In Brazil, a previous work found EBV infection in 4 of 80 (5%) gastric carcinomas, whereas another study found 4.7 and 11.2% of EBV-positive gastric carcinomas of Brazilians of Japanese origin or not, respectively. In the present study, the frequency of EBV-positive gastric carcinomas is similar to that reported in other series, and the clinicopathologic characteristics of these EBV-positive tumors are in agreement with the data in the literature.
publishDate 2004
dc.date.none.fl_str_mv 2004-11-01
2014-05-20T13:37:41Z
2014-05-20T13:37:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2004001100016
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 11, p. 1707-1712, 2004.
0100-879X
http://hdl.handle.net/11449/13063
10.1590/S0100-879X2004001100016
S0100-879X2004001100016
2-s2.0-9244244298
S0100-879X2004001100016.pdf
0000-0001-5562-9648
url http://dx.doi.org/10.1590/S0100-879X2004001100016
http://hdl.handle.net/11449/13063
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 37, n. 11, p. 1707-1712, 2004.
0100-879X
10.1590/S0100-879X2004001100016
S0100-879X2004001100016
2-s2.0-9244244298
S0100-879X2004001100016.pdf
0000-0001-5562-9648
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
1.492
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1707-1712
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica (ABRADIC)
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica (ABRADIC)
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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