Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.archoralbio.2018.01.003 http://hdl.handle.net/11449/179649 |
Resumo: | Objective: This case-control study aimed to evaluate the effects of conventional radiotherapy (RT) on the prevalence and populations of oral microorganisms in head and neck cancer patients who did not receive adequate preventive dental care. It was hypothesized that side effects of radiotherapy could be associated with radiation dose, microbiological aspects, and socioeconomic conditions of the patients. Design: Twenty-eight dentate patients with head and neck cancer submitted to RT were included in the study. Radiation dose received varied from 4320 to 7020 cGy. Patients with the same demographic and health conditions, but no history of cancer or antineoplastic treatment were used as controls. Clinical examinations were carried out before RT, 15–22 days after starting RT, immediately after and 6 months after RT. Supra and subgingival biofilms were collected and cultivated onto selective and non-selective media. Isolates were identified by biochemical and physiological characteristics. Stimulated and unstimulated salivary flow rate and saliva buffer capacity were also determined. Results: Mucositis, dermatitis, xerostomia, dysgeusia, dysphagia and candidiasis were common after starting RT and during the treatment period. Xerostomia was followed by a decrease in salivary pH and buffer capacity, which showed association with the increase of cariogenic cocci and yeast populations, which were also associated with deterioration of hygiene. Candida and family Enterobacteriaceae showed increased prevalence with RT, and were associated with the occurrence of mucositis and xerostomia. Conclusions: Modifications in oral biofilms of irradiated patients showed association with xerostomia and hygiene conditions, which reinforces the necessity of improving patient compliance to oral health care programs. |
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Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatmentHead and neck radiotherapyMicrobiologyMucositisOral cancerXerostomiaObjective: This case-control study aimed to evaluate the effects of conventional radiotherapy (RT) on the prevalence and populations of oral microorganisms in head and neck cancer patients who did not receive adequate preventive dental care. It was hypothesized that side effects of radiotherapy could be associated with radiation dose, microbiological aspects, and socioeconomic conditions of the patients. Design: Twenty-eight dentate patients with head and neck cancer submitted to RT were included in the study. Radiation dose received varied from 4320 to 7020 cGy. Patients with the same demographic and health conditions, but no history of cancer or antineoplastic treatment were used as controls. Clinical examinations were carried out before RT, 15–22 days after starting RT, immediately after and 6 months after RT. Supra and subgingival biofilms were collected and cultivated onto selective and non-selective media. Isolates were identified by biochemical and physiological characteristics. Stimulated and unstimulated salivary flow rate and saliva buffer capacity were also determined. Results: Mucositis, dermatitis, xerostomia, dysgeusia, dysphagia and candidiasis were common after starting RT and during the treatment period. Xerostomia was followed by a decrease in salivary pH and buffer capacity, which showed association with the increase of cariogenic cocci and yeast populations, which were also associated with deterioration of hygiene. Candida and family Enterobacteriaceae showed increased prevalence with RT, and were associated with the occurrence of mucositis and xerostomia. Conclusions: Modifications in oral biofilms of irradiated patients showed association with xerostomia and hygiene conditions, which reinforces the necessity of improving patient compliance to oral health care programs.São Paulo State University (UNESP) School of Dentistry Department of Pathology and Clinical PropaedeuticsSchool of Dentistry of Campo Grande Universidade Federal do Mato Grosso do SulSão Paulo State University (UNESP) School of Natural Sciences and Engineering Department of MathematicsSão Paulo State University (UNESP) School of Dentistry Department of Pathology and Clinical PropaedeuticsSão Paulo State University (UNESP) School of Natural Sciences and Engineering Department of MathematicsUniversidade Estadual Paulista (Unesp)Universidade Federal do Mato Grosso do SulGaetti-Jardim, Elerson [UNESP]Jardim, Ellen Cristina GaettiSchweitzer, Christiane Marie [UNESP]da Silva, Júlio Cesar LeiteOliveira, Murilo MouraMasocatto, Danilo Chizzolinidos Santos, Cauê Monteiro2018-12-11T17:36:11Z2018-12-11T17:36:11Z2018-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article45-52application/pdfhttp://dx.doi.org/10.1016/j.archoralbio.2018.01.003Archives of Oral Biology, v. 90, p. 45-52.1879-15060003-9969http://hdl.handle.net/11449/17964910.1016/j.archoralbio.2018.01.0032-s2.0-850433820932-s2.0-85043382093.pdf00011553552103270000-0001-9561-8281Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Oral Biology0,752info:eu-repo/semantics/openAccess2024-07-10T15:41:36Zoai:repositorio.unesp.br:11449/179649Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:15:29.646185Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment |
title |
Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment |
spellingShingle |
Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment Gaetti-Jardim, Elerson [UNESP] Head and neck radiotherapy Microbiology Mucositis Oral cancer Xerostomia |
title_short |
Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment |
title_full |
Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment |
title_fullStr |
Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment |
title_full_unstemmed |
Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment |
title_sort |
Supragingival and subgingival microbiota from patients with poor oral hygiene submitted to radiotherapy for head and neck cancer treatment |
author |
Gaetti-Jardim, Elerson [UNESP] |
author_facet |
Gaetti-Jardim, Elerson [UNESP] Jardim, Ellen Cristina Gaetti Schweitzer, Christiane Marie [UNESP] da Silva, Júlio Cesar Leite Oliveira, Murilo Moura Masocatto, Danilo Chizzolini dos Santos, Cauê Monteiro |
author_role |
author |
author2 |
Jardim, Ellen Cristina Gaetti Schweitzer, Christiane Marie [UNESP] da Silva, Júlio Cesar Leite Oliveira, Murilo Moura Masocatto, Danilo Chizzolini dos Santos, Cauê Monteiro |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal do Mato Grosso do Sul |
dc.contributor.author.fl_str_mv |
Gaetti-Jardim, Elerson [UNESP] Jardim, Ellen Cristina Gaetti Schweitzer, Christiane Marie [UNESP] da Silva, Júlio Cesar Leite Oliveira, Murilo Moura Masocatto, Danilo Chizzolini dos Santos, Cauê Monteiro |
dc.subject.por.fl_str_mv |
Head and neck radiotherapy Microbiology Mucositis Oral cancer Xerostomia |
topic |
Head and neck radiotherapy Microbiology Mucositis Oral cancer Xerostomia |
description |
Objective: This case-control study aimed to evaluate the effects of conventional radiotherapy (RT) on the prevalence and populations of oral microorganisms in head and neck cancer patients who did not receive adequate preventive dental care. It was hypothesized that side effects of radiotherapy could be associated with radiation dose, microbiological aspects, and socioeconomic conditions of the patients. Design: Twenty-eight dentate patients with head and neck cancer submitted to RT were included in the study. Radiation dose received varied from 4320 to 7020 cGy. Patients with the same demographic and health conditions, but no history of cancer or antineoplastic treatment were used as controls. Clinical examinations were carried out before RT, 15–22 days after starting RT, immediately after and 6 months after RT. Supra and subgingival biofilms were collected and cultivated onto selective and non-selective media. Isolates were identified by biochemical and physiological characteristics. Stimulated and unstimulated salivary flow rate and saliva buffer capacity were also determined. Results: Mucositis, dermatitis, xerostomia, dysgeusia, dysphagia and candidiasis were common after starting RT and during the treatment period. Xerostomia was followed by a decrease in salivary pH and buffer capacity, which showed association with the increase of cariogenic cocci and yeast populations, which were also associated with deterioration of hygiene. Candida and family Enterobacteriaceae showed increased prevalence with RT, and were associated with the occurrence of mucositis and xerostomia. Conclusions: Modifications in oral biofilms of irradiated patients showed association with xerostomia and hygiene conditions, which reinforces the necessity of improving patient compliance to oral health care programs. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:36:11Z 2018-12-11T17:36:11Z 2018-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.archoralbio.2018.01.003 Archives of Oral Biology, v. 90, p. 45-52. 1879-1506 0003-9969 http://hdl.handle.net/11449/179649 10.1016/j.archoralbio.2018.01.003 2-s2.0-85043382093 2-s2.0-85043382093.pdf 0001155355210327 0000-0001-9561-8281 |
url |
http://dx.doi.org/10.1016/j.archoralbio.2018.01.003 http://hdl.handle.net/11449/179649 |
identifier_str_mv |
Archives of Oral Biology, v. 90, p. 45-52. 1879-1506 0003-9969 10.1016/j.archoralbio.2018.01.003 2-s2.0-85043382093 2-s2.0-85043382093.pdf 0001155355210327 0000-0001-9561-8281 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of Oral Biology 0,752 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
45-52 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128489633611776 |