Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females
Autor(a) principal: | |
---|---|
Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.mce.2023.111892 http://hdl.handle.net/11449/248471 |
Resumo: | The ovaries regulate fertility and hormonal control in females, and aging is a crucial factor in this process, when ovarian function is drastically impacted. Exogenous endocrine disruptors may accelerate this process, acting as the main agents in decreased female fertility and hormonal imbalance, since they impact different features related to reproduction. In the present study, we demonstrate the implications of exposure of adult mothers to the endocrine disruptor bisphenol A (BPA) during pregnancy and lactation on their ovarian function during the transition to later in life (aging). The follicle population of BPA exposed ovaries showed impairment in the development of follicles to the mature stages, with growing follicles being halted in the early stages. Atretic and early-atretic follicles were also enhanced. Expression of estrogen and androgen receptors in the follicle population demonstrated impairment in signaling function: ERβ was highly expressed in follicles from BPA exposed females, which also showed a higher incidence of early atresia of developed follicles. ERβ1 wild-type isoform was also enhanced in BPA-exposed ovaries, compared to its variant isoforms. In addition, steroidogenesis was targeted by BPA exposure: aromatase and 17-β-HSD were reduced, whereas 5-α reductase was enhanced. This modulation was reflected in serum levels of estradiol and testosterone, which decreased in BPA-exposed females. Imbalances in steroidogenesis impair the development of follicles and play an important role in follicular atresia. Our study demonstrated that BPA exposure in two windows of susceptibility – gestation and lactation – had implications during aging, enhancing perimenopausal and infertile features. |
id |
UNSP_5791f627ab7b1e89ed728cac205a1f79 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/248471 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged femalesEndocrine disruptionHormone receptorOvarian agingReproductionThe ovaries regulate fertility and hormonal control in females, and aging is a crucial factor in this process, when ovarian function is drastically impacted. Exogenous endocrine disruptors may accelerate this process, acting as the main agents in decreased female fertility and hormonal imbalance, since they impact different features related to reproduction. In the present study, we demonstrate the implications of exposure of adult mothers to the endocrine disruptor bisphenol A (BPA) during pregnancy and lactation on their ovarian function during the transition to later in life (aging). The follicle population of BPA exposed ovaries showed impairment in the development of follicles to the mature stages, with growing follicles being halted in the early stages. Atretic and early-atretic follicles were also enhanced. Expression of estrogen and androgen receptors in the follicle population demonstrated impairment in signaling function: ERβ was highly expressed in follicles from BPA exposed females, which also showed a higher incidence of early atresia of developed follicles. ERβ1 wild-type isoform was also enhanced in BPA-exposed ovaries, compared to its variant isoforms. In addition, steroidogenesis was targeted by BPA exposure: aromatase and 17-β-HSD were reduced, whereas 5-α reductase was enhanced. This modulation was reflected in serum levels of estradiol and testosterone, which decreased in BPA-exposed females. Imbalances in steroidogenesis impair the development of follicles and play an important role in follicular atresia. Our study demonstrated that BPA exposure in two windows of susceptibility – gestation and lactation – had implications during aging, enhancing perimenopausal and infertile features.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Institute of Biology University of Campinas (UNICAMP), SPDepartment of Biological Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São José do Rio PretoDepartment of Histology Embryology and Cell Biology Institute of Biological Sciences (ICB III) Federal University of Goiás (UFG), GoiásDepartment of Biological Sciences Institute of Biosciences Humanities and Exact Sciences São Paulo State University (UNESP), São José do Rio PretoCAPES: 001FAPESP: 20/00160-1FAPESP: 20/01240-9FAPESP: 22/00521-0CNPq: 302938/2020-6Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Universidade Federal de Goiás (UFG)Ruiz, Thalles F.R.Grigio, Vitor [UNESP]Ferrato, Luara J. [UNESP]de Souza, Lorena G. [UNESP]Colleta, Simone J. [UNESP]Amaro, Gustavo M. [UNESP]Góes, Rejane M. [UNESP]Vilamaior, Patrícia S.L. [UNESP]Leonel, Ellen C.R.Taboga, Sebastião R. [UNESP]2023-07-29T13:44:57Z2023-07-29T13:44:57Z2023-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.mce.2023.111892Molecular and Cellular Endocrinology, v. 566-567.1872-80570303-7207http://hdl.handle.net/11449/24847110.1016/j.mce.2023.1118922-s2.0-85149453189Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMolecular and Cellular Endocrinologyinfo:eu-repo/semantics/openAccess2023-07-29T13:44:57Zoai:repositorio.unesp.br:11449/248471Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:10:44.519216Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females |
title |
Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females |
spellingShingle |
Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females Ruiz, Thalles F.R. Endocrine disruption Hormone receptor Ovarian aging Reproduction |
title_short |
Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females |
title_full |
Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females |
title_fullStr |
Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females |
title_full_unstemmed |
Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females |
title_sort |
Impairment of steroidogenesis and follicle development after bisphenol A exposure during pregnancy and lactation in the ovaries of Mongolian gerbils aged females |
author |
Ruiz, Thalles F.R. |
author_facet |
Ruiz, Thalles F.R. Grigio, Vitor [UNESP] Ferrato, Luara J. [UNESP] de Souza, Lorena G. [UNESP] Colleta, Simone J. [UNESP] Amaro, Gustavo M. [UNESP] Góes, Rejane M. [UNESP] Vilamaior, Patrícia S.L. [UNESP] Leonel, Ellen C.R. Taboga, Sebastião R. [UNESP] |
author_role |
author |
author2 |
Grigio, Vitor [UNESP] Ferrato, Luara J. [UNESP] de Souza, Lorena G. [UNESP] Colleta, Simone J. [UNESP] Amaro, Gustavo M. [UNESP] Góes, Rejane M. [UNESP] Vilamaior, Patrícia S.L. [UNESP] Leonel, Ellen C.R. Taboga, Sebastião R. [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (UNESP) Universidade Federal de Goiás (UFG) |
dc.contributor.author.fl_str_mv |
Ruiz, Thalles F.R. Grigio, Vitor [UNESP] Ferrato, Luara J. [UNESP] de Souza, Lorena G. [UNESP] Colleta, Simone J. [UNESP] Amaro, Gustavo M. [UNESP] Góes, Rejane M. [UNESP] Vilamaior, Patrícia S.L. [UNESP] Leonel, Ellen C.R. Taboga, Sebastião R. [UNESP] |
dc.subject.por.fl_str_mv |
Endocrine disruption Hormone receptor Ovarian aging Reproduction |
topic |
Endocrine disruption Hormone receptor Ovarian aging Reproduction |
description |
The ovaries regulate fertility and hormonal control in females, and aging is a crucial factor in this process, when ovarian function is drastically impacted. Exogenous endocrine disruptors may accelerate this process, acting as the main agents in decreased female fertility and hormonal imbalance, since they impact different features related to reproduction. In the present study, we demonstrate the implications of exposure of adult mothers to the endocrine disruptor bisphenol A (BPA) during pregnancy and lactation on their ovarian function during the transition to later in life (aging). The follicle population of BPA exposed ovaries showed impairment in the development of follicles to the mature stages, with growing follicles being halted in the early stages. Atretic and early-atretic follicles were also enhanced. Expression of estrogen and androgen receptors in the follicle population demonstrated impairment in signaling function: ERβ was highly expressed in follicles from BPA exposed females, which also showed a higher incidence of early atresia of developed follicles. ERβ1 wild-type isoform was also enhanced in BPA-exposed ovaries, compared to its variant isoforms. In addition, steroidogenesis was targeted by BPA exposure: aromatase and 17-β-HSD were reduced, whereas 5-α reductase was enhanced. This modulation was reflected in serum levels of estradiol and testosterone, which decreased in BPA-exposed females. Imbalances in steroidogenesis impair the development of follicles and play an important role in follicular atresia. Our study demonstrated that BPA exposure in two windows of susceptibility – gestation and lactation – had implications during aging, enhancing perimenopausal and infertile features. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:44:57Z 2023-07-29T13:44:57Z 2023-05-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.mce.2023.111892 Molecular and Cellular Endocrinology, v. 566-567. 1872-8057 0303-7207 http://hdl.handle.net/11449/248471 10.1016/j.mce.2023.111892 2-s2.0-85149453189 |
url |
http://dx.doi.org/10.1016/j.mce.2023.111892 http://hdl.handle.net/11449/248471 |
identifier_str_mv |
Molecular and Cellular Endocrinology, v. 566-567. 1872-8057 0303-7207 10.1016/j.mce.2023.111892 2-s2.0-85149453189 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Molecular and Cellular Endocrinology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128905194766336 |