Critical defect healing assessment in rat calvaria filled with injectable calcium phosphate cement

• Autor(a) principal: Schmidt, Luis Eduardo
• Data de Publicação: 2019
• Outros Autores: Hadad, Henrique [UNESP], De Vasconcelos, Igor Rodrigues, Colombo, Luara Teixeira [UNESP], Da Silva, Rodrigo Capalbo [UNESP], Santos, Ana Flavia Piquera [UNESP], Cervantes, Lara Cristina Cunha [UNESP], Poli, Pier Paolo, Signorino, Fabrizio, Maiorana, Carlo, De Carvalho, Paulo Sérgio Perri, Souza, Francisley Ávila [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.3390/jfb10020021; http://hdl.handle.net/11449/189238
• topic: Biomaterial; Bone healing; Calcium phosphate cement

(1) Background: The tissue engineering field has been working to find biomaterials that mimic the biological properties of autogenous bone grafts. (2) Aim: To evaluate the osteoconduction potential of injectable calcium phosphate cement implanted in critical defects in rat calvaria. (3) Methods: In the calvarial bone of 36 rats, 7-mm diameter critical size defects were performed. Afterwards, the animals were randomly divided into three groups according to filler material: a blood clot group (BC), blood clot membrane group (BCM), and an injectable β-tricalcium phosphate group (HBS) cement group. After periods of 30 and 60 days, the animals were euthanized, the calvaria was isolated, and submitted to a decalcification process for later blades confection. Qualitative and quantitative analysis of the neoformed bone tissue were conducted, and histometric data were statistically analyzed. (4) Results: Sixty days post-surgery, the percentages of neoformed bone were 10.67 ± 5.57 in group BC, 16.71 ± 5.0 in group BCM, and 55.11 ± 13.20 in group HBS. The bone formation values in group HBS were significantly higher (p < 0.05) than in groups BC and BCM. (5) Conclusions: Based on these results, it can be concluded that injectable calcium phosphate cement is an osteoconductive material that can be used to fill bone cavities.