Explanation for the signs and symptoms of tooth eruption: mast cells
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/2177-6709.24.2.020-031.oin http://hdl.handle.net/11449/183830 |
Resumo: | Abstract This study contributes to the understanding of the mechanisms associated with signs and symptoms of tooth eruption, by investigating the presence of mast cells in pericoronal tissues during the intraosseous (Group 1) and submucosal (Group 2) phases of eruption. We compared findings for these two groups with each other and with those for the oral mucosa (Group 3). In each group, 14 specimens were analyzed microscopically after hematoxylin and eosin staining and immunohistochemical analysis of c-Kit and tryptase expression. Results revealed that the number and density of mast cells is different in follicular tissues according to the eruption phase, which may mean that: 1) masticatory trauma of the oral mucosa and dental follicles in the submucosa may explain why reduced enamel epithelium exposes enamel to the cells of the connective tissue; 2) exposure of antigenic enamel proteins might correspond to the release of sequestered antigens, which may lead to the interaction of IgE and a greater number of mast cells in the region; and 3) the consequent degranulation and the local release of mediators, such as histamine, leukotrienes, prostaglandins, proteases, cytokines and growth factors, contribute to the understanding of signs and symptoms associated with tooth eruption. |
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Explanation for the signs and symptoms of tooth eruption: mast cellsTooth eruptionDental follicleMast cellsOdontogenesisErupção dentáriaFolículo pericoronárioMastócitosOdontogêneseAbstract This study contributes to the understanding of the mechanisms associated with signs and symptoms of tooth eruption, by investigating the presence of mast cells in pericoronal tissues during the intraosseous (Group 1) and submucosal (Group 2) phases of eruption. We compared findings for these two groups with each other and with those for the oral mucosa (Group 3). In each group, 14 specimens were analyzed microscopically after hematoxylin and eosin staining and immunohistochemical analysis of c-Kit and tryptase expression. Results revealed that the number and density of mast cells is different in follicular tissues according to the eruption phase, which may mean that: 1) masticatory trauma of the oral mucosa and dental follicles in the submucosa may explain why reduced enamel epithelium exposes enamel to the cells of the connective tissue; 2) exposure of antigenic enamel proteins might correspond to the release of sequestered antigens, which may lead to the interaction of IgE and a greater number of mast cells in the region; and 3) the consequent degranulation and the local release of mediators, such as histamine, leukotrienes, prostaglandins, proteases, cytokines and growth factors, contribute to the understanding of signs and symptoms associated with tooth eruption.Resumo Para contribuir com a compreensão dos mecanismos relacionados à sintomatologia e aos sinais associados à erupção dentária, investigou-se a presença de mastócitos nos tecidos pericoronários na fase intraóssea (Grupo 1) e submucosa (Grupo 2), comparando-os entre si e com a mucosa bucal (Grupo 3). Em cada grupo, 14 espécimes foram analisados microscopicamente em cortes corados com hematoxilina e eosina, e imunocitoquimicamente marcados com Ckit e Triptase. Pelos resultados obtidos, concluiu-se que a quantidade/densidade dos mastócitos é diferente nos tecidos foliculares de acordo com a fase de erupção, o que permite inferir que: 1) O traumatismo decorrente da mastigação sobre o conjunto “mucosa bucal com o folículo pericoronário na submucosa” pode explicar porque o epitélio reduzido exporia o esmalte às células do tecido conjuntivo; 2) A exposição das proteínas do esmalte com propriedades antigênicas corresponderia à liberação de antígenos sequestrados que levariam à interação de IgE e mastócitos em número aumentado na região; e 3) A consequente degranulação e liberação de mediadores no local, como histamina, leucotrienes, prostaglandinas, proteases, citocinas e fatores de crescimento, contribuem para a compreensão dos sinais e sintomatologia atribuídos à erupção dentária.Universidade Nove de Julho Faculdade de MedicinaUniversidade Estadual Paulista Faculdade de MedicinaBauruUniversidade de São Paulo Faculdade de Odontologia de BauruUniversidade de São Paulo Faculdade de Odontologia de Ribeirão PretoUniversidade Estadual Paulista Faculdade de MedicinaDental Press InternationalUniversidade Nove de Julho Faculdade de MedicinaUniversidade Estadual Paulista (Unesp)BauruUniversidade de São Paulo (USP)Franzolin, Solange De Oliveira BragaPardini, Maria Inês Moura CamposFrancischone, Leda A.Deffune, EleniceConsolaro, Alberto2019-10-03T17:31:49Z2019-10-03T17:31:49Z2019-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20-31application/pdfhttp://dx.doi.org/10.1590/2177-6709.24.2.020-031.oinDental Press Journal of Orthodontics. Dental Press International, v. 24, n. 2, p. 20-31, 2019.2176-9451http://hdl.handle.net/11449/18383010.1590/2177-6709.24.2.020-031.oinS2176-94512019000200020S2176-94512019000200020.pdf4619588334582084SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDental Press Journal of Orthodonticsinfo:eu-repo/semantics/openAccess2023-10-28T06:10:01Zoai:repositorio.unesp.br:11449/183830Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-10-28T06:10:01Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Explanation for the signs and symptoms of tooth eruption: mast cells |
title |
Explanation for the signs and symptoms of tooth eruption: mast cells |
spellingShingle |
Explanation for the signs and symptoms of tooth eruption: mast cells Franzolin, Solange De Oliveira Braga Tooth eruption Dental follicle Mast cells Odontogenesis Erupção dentária Folículo pericoronário Mastócitos Odontogênese |
title_short |
Explanation for the signs and symptoms of tooth eruption: mast cells |
title_full |
Explanation for the signs and symptoms of tooth eruption: mast cells |
title_fullStr |
Explanation for the signs and symptoms of tooth eruption: mast cells |
title_full_unstemmed |
Explanation for the signs and symptoms of tooth eruption: mast cells |
title_sort |
Explanation for the signs and symptoms of tooth eruption: mast cells |
author |
Franzolin, Solange De Oliveira Braga |
author_facet |
Franzolin, Solange De Oliveira Braga Pardini, Maria Inês Moura Campos Francischone, Leda A. Deffune, Elenice Consolaro, Alberto |
author_role |
author |
author2 |
Pardini, Maria Inês Moura Campos Francischone, Leda A. Deffune, Elenice Consolaro, Alberto |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Nove de Julho Faculdade de Medicina Universidade Estadual Paulista (Unesp) Bauru Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Franzolin, Solange De Oliveira Braga Pardini, Maria Inês Moura Campos Francischone, Leda A. Deffune, Elenice Consolaro, Alberto |
dc.subject.por.fl_str_mv |
Tooth eruption Dental follicle Mast cells Odontogenesis Erupção dentária Folículo pericoronário Mastócitos Odontogênese |
topic |
Tooth eruption Dental follicle Mast cells Odontogenesis Erupção dentária Folículo pericoronário Mastócitos Odontogênese |
description |
Abstract This study contributes to the understanding of the mechanisms associated with signs and symptoms of tooth eruption, by investigating the presence of mast cells in pericoronal tissues during the intraosseous (Group 1) and submucosal (Group 2) phases of eruption. We compared findings for these two groups with each other and with those for the oral mucosa (Group 3). In each group, 14 specimens were analyzed microscopically after hematoxylin and eosin staining and immunohistochemical analysis of c-Kit and tryptase expression. Results revealed that the number and density of mast cells is different in follicular tissues according to the eruption phase, which may mean that: 1) masticatory trauma of the oral mucosa and dental follicles in the submucosa may explain why reduced enamel epithelium exposes enamel to the cells of the connective tissue; 2) exposure of antigenic enamel proteins might correspond to the release of sequestered antigens, which may lead to the interaction of IgE and a greater number of mast cells in the region; and 3) the consequent degranulation and the local release of mediators, such as histamine, leukotrienes, prostaglandins, proteases, cytokines and growth factors, contribute to the understanding of signs and symptoms associated with tooth eruption. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-03T17:31:49Z 2019-10-03T17:31:49Z 2019-04-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/2177-6709.24.2.020-031.oin Dental Press Journal of Orthodontics. Dental Press International, v. 24, n. 2, p. 20-31, 2019. 2176-9451 http://hdl.handle.net/11449/183830 10.1590/2177-6709.24.2.020-031.oin S2176-94512019000200020 S2176-94512019000200020.pdf 4619588334582084 |
url |
http://dx.doi.org/10.1590/2177-6709.24.2.020-031.oin http://hdl.handle.net/11449/183830 |
identifier_str_mv |
Dental Press Journal of Orthodontics. Dental Press International, v. 24, n. 2, p. 20-31, 2019. 2176-9451 10.1590/2177-6709.24.2.020-031.oin S2176-94512019000200020 S2176-94512019000200020.pdf 4619588334582084 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Dental Press Journal of Orthodontics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
20-31 application/pdf |
dc.publisher.none.fl_str_mv |
Dental Press International |
publisher.none.fl_str_mv |
Dental Press International |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803046204941008896 |