Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/127513 |
Resumo: | To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model. |
| id |
UNSP_58b642de93c33cae5162f445dca25521 |
|---|---|
| oai_identifier_str |
oai:repositorio.unesp.br:11449/127513 |
| network_acronym_str |
UNSP |
| network_name_str |
Repositório Institucional da UNESP |
| repository_id_str |
2946 |
| spelling |
Parecoxib reduces renal injury in an ischemia/reperfusion model in ratsParecoxibIschemiaReperfusionKidneyRatsTo evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model.UNESPPostgraduate Program in Anesthesiology, Botucatu Medical School, Sao Paulo State University (UNESP), Brazil. Conception, design, intellectual and scientific content of the studyDepartment of Pathology, Botucatu Medical School, UNESP, Botucatu-SP, Brazil. Acquisition and interpretation of data, histological examinationsSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaUniversidade Estadual Paulista (Unesp)Calistro Neto, José Pedro [UNESP]Torres, Rômulo da Costa [UNESP]Gonçalves, Giovanna Maria [UNESP]Silva, Leopoldo Muniz da [UNESP]Domingues, Maria Aparecida Custódio [UNESP]Módolo, Norma Sueli Pinheiro [UNESP]Barros, Guilherme Antonio Moreira de [UNESP]2015-08-26T19:22:37Z2015-08-26T19:22:37Z2015-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article270-276application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270&lng=en&nrm=iso&tlng=enActa Cirurgica Brasileira, v. 30, n. 4, p. 270-276, 2015.0102-8650http://hdl.handle.net/11449/12751310.1590/S0102-865020150040000006S0102-86502015000400270S0102-86502015000400270.pdf82235464757240580585723113037140SciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengActa Cirurgica Brasileira0.9330,395info:eu-repo/semantics/openAccess2024-09-03T13:18:23Zoai:repositorio.unesp.br:11449/127513Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:18:23Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
| title |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
| spellingShingle |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats Calistro Neto, José Pedro [UNESP] Parecoxib Ischemia Reperfusion Kidney Rats |
| title_short |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
| title_full |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
| title_fullStr |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
| title_full_unstemmed |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
| title_sort |
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats |
| author |
Calistro Neto, José Pedro [UNESP] |
| author_facet |
Calistro Neto, José Pedro [UNESP] Torres, Rômulo da Costa [UNESP] Gonçalves, Giovanna Maria [UNESP] Silva, Leopoldo Muniz da [UNESP] Domingues, Maria Aparecida Custódio [UNESP] Módolo, Norma Sueli Pinheiro [UNESP] Barros, Guilherme Antonio Moreira de [UNESP] |
| author_role |
author |
| author2 |
Torres, Rômulo da Costa [UNESP] Gonçalves, Giovanna Maria [UNESP] Silva, Leopoldo Muniz da [UNESP] Domingues, Maria Aparecida Custódio [UNESP] Módolo, Norma Sueli Pinheiro [UNESP] Barros, Guilherme Antonio Moreira de [UNESP] |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
| dc.contributor.author.fl_str_mv |
Calistro Neto, José Pedro [UNESP] Torres, Rômulo da Costa [UNESP] Gonçalves, Giovanna Maria [UNESP] Silva, Leopoldo Muniz da [UNESP] Domingues, Maria Aparecida Custódio [UNESP] Módolo, Norma Sueli Pinheiro [UNESP] Barros, Guilherme Antonio Moreira de [UNESP] |
| dc.subject.por.fl_str_mv |
Parecoxib Ischemia Reperfusion Kidney Rats |
| topic |
Parecoxib Ischemia Reperfusion Kidney Rats |
| description |
To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-08-26T19:22:37Z 2015-08-26T19:22:37Z 2015-04-01 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270&lng=en&nrm=iso&tlng=en Acta Cirurgica Brasileira, v. 30, n. 4, p. 270-276, 2015. 0102-8650 http://hdl.handle.net/11449/127513 10.1590/S0102-865020150040000006 S0102-86502015000400270 S0102-86502015000400270.pdf 8223546475724058 0585723113037140 |
| url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000400270&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/127513 |
| identifier_str_mv |
Acta Cirurgica Brasileira, v. 30, n. 4, p. 270-276, 2015. 0102-8650 10.1590/S0102-865020150040000006 S0102-86502015000400270 S0102-86502015000400270.pdf 8223546475724058 0585723113037140 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Acta Cirurgica Brasileira 0.933 0,395 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
270-276 application/pdf |
| dc.publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| publisher.none.fl_str_mv |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| instname_str |
Universidade Estadual Paulista (UNESP) |
| instacron_str |
UNESP |
| institution |
UNESP |
| reponame_str |
Repositório Institucional da UNESP |
| collection |
Repositório Institucional da UNESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
| repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
| _version_ |
1810021411673079808 |