Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.cca.2016.08.002 http://hdl.handle.net/11449/173323 |
Resumo: | Background Several evidences report that a vegetarian diet is protector against cardiovascular diseases. Few studies have demonstrated the circulating profile of cardiovascular biomarkers in vegetarians. Therefore, the aims of the current study were compared the plasma concentrations of myeloperoxidase (MPO), metalloproteinase (MMP)-9, MMP-2, tissue inhibitor of MMP (TIMP)-1 and TIMP-2 between healthy vegetarian (Veg) and healthy omnivorous (Omn). Methods Using ELISA and multiplexed bead immunoassay, we measured in plasma from 43 Veg and 41 Omn the cardiovascular biomarkers concentrations cited above. Results We found significant lower concentrations of MPO, MMP-9, MMP-2 and MMP-9/TIMP-1 ratio in Veg compared to Omn (all P < 0.05). Moreover, MMP-9 concentrations were correlated positively with leukocytes and neutrophils count in both groups (all P < 0.05). Conclusion A vegetarian diet is associated with a healthier profile of cardiovascular biomarkers compared to omnivorous. |
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Repositório Institucional da UNESP |
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Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian menCardiovascular biomarkersMMP-2MMP-9MPOOmnivorousTIMPVegetariansBackground Several evidences report that a vegetarian diet is protector against cardiovascular diseases. Few studies have demonstrated the circulating profile of cardiovascular biomarkers in vegetarians. Therefore, the aims of the current study were compared the plasma concentrations of myeloperoxidase (MPO), metalloproteinase (MMP)-9, MMP-2, tissue inhibitor of MMP (TIMP)-1 and TIMP-2 between healthy vegetarian (Veg) and healthy omnivorous (Omn). Methods Using ELISA and multiplexed bead immunoassay, we measured in plasma from 43 Veg and 41 Omn the cardiovascular biomarkers concentrations cited above. Results We found significant lower concentrations of MPO, MMP-9, MMP-2 and MMP-9/TIMP-1 ratio in Veg compared to Omn (all P < 0.05). Moreover, MMP-9 concentrations were correlated positively with leukocytes and neutrophils count in both groups (all P < 0.05). Conclusion A vegetarian diet is associated with a healthier profile of cardiovascular biomarkers compared to omnivorous.Heart Institute Faculdade de Medicina Universidade de Sao PauloDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)Department of Pharmacology Faculty of Medicine of Ribeirao Preto Universidade de Sao Paulo (FMRP-USP)Department of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)Universidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Navarro, Julio Acostade Gouveia, Luiza AntoniazziRocha-Penha, Lilliam [UNESP]Cinegaglia, Naiara [UNESP]Belo, VanessaCastro, Michele Mazzaron deSandrim, Valeria Cristina [UNESP]2018-12-11T17:04:39Z2018-12-11T17:04:39Z2016-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article110-113application/pdfhttp://dx.doi.org/10.1016/j.cca.2016.08.002Clinica Chimica Acta, v. 461, p. 110-113.1873-34920009-8981http://hdl.handle.net/11449/17332310.1016/j.cca.2016.08.0022-s2.0-849803197222-s2.0-84980319722.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinica Chimica Acta1,102info:eu-repo/semantics/openAccess2023-11-18T06:14:41Zoai:repositorio.unesp.br:11449/173323Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:04:37.543193Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men |
title |
Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men |
spellingShingle |
Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men Navarro, Julio Acosta Cardiovascular biomarkers MMP-2 MMP-9 MPO Omnivorous TIMP Vegetarians |
title_short |
Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men |
title_full |
Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men |
title_fullStr |
Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men |
title_full_unstemmed |
Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men |
title_sort |
Reduced levels of potential circulating biomarkers of cardiovascular diseases in apparently healthy vegetarian men |
author |
Navarro, Julio Acosta |
author_facet |
Navarro, Julio Acosta de Gouveia, Luiza Antoniazzi Rocha-Penha, Lilliam [UNESP] Cinegaglia, Naiara [UNESP] Belo, Vanessa Castro, Michele Mazzaron de Sandrim, Valeria Cristina [UNESP] |
author_role |
author |
author2 |
de Gouveia, Luiza Antoniazzi Rocha-Penha, Lilliam [UNESP] Cinegaglia, Naiara [UNESP] Belo, Vanessa Castro, Michele Mazzaron de Sandrim, Valeria Cristina [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Navarro, Julio Acosta de Gouveia, Luiza Antoniazzi Rocha-Penha, Lilliam [UNESP] Cinegaglia, Naiara [UNESP] Belo, Vanessa Castro, Michele Mazzaron de Sandrim, Valeria Cristina [UNESP] |
dc.subject.por.fl_str_mv |
Cardiovascular biomarkers MMP-2 MMP-9 MPO Omnivorous TIMP Vegetarians |
topic |
Cardiovascular biomarkers MMP-2 MMP-9 MPO Omnivorous TIMP Vegetarians |
description |
Background Several evidences report that a vegetarian diet is protector against cardiovascular diseases. Few studies have demonstrated the circulating profile of cardiovascular biomarkers in vegetarians. Therefore, the aims of the current study were compared the plasma concentrations of myeloperoxidase (MPO), metalloproteinase (MMP)-9, MMP-2, tissue inhibitor of MMP (TIMP)-1 and TIMP-2 between healthy vegetarian (Veg) and healthy omnivorous (Omn). Methods Using ELISA and multiplexed bead immunoassay, we measured in plasma from 43 Veg and 41 Omn the cardiovascular biomarkers concentrations cited above. Results We found significant lower concentrations of MPO, MMP-9, MMP-2 and MMP-9/TIMP-1 ratio in Veg compared to Omn (all P < 0.05). Moreover, MMP-9 concentrations were correlated positively with leukocytes and neutrophils count in both groups (all P < 0.05). Conclusion A vegetarian diet is associated with a healthier profile of cardiovascular biomarkers compared to omnivorous. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-01 2018-12-11T17:04:39Z 2018-12-11T17:04:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.cca.2016.08.002 Clinica Chimica Acta, v. 461, p. 110-113. 1873-3492 0009-8981 http://hdl.handle.net/11449/173323 10.1016/j.cca.2016.08.002 2-s2.0-84980319722 2-s2.0-84980319722.pdf |
url |
http://dx.doi.org/10.1016/j.cca.2016.08.002 http://hdl.handle.net/11449/173323 |
identifier_str_mv |
Clinica Chimica Acta, v. 461, p. 110-113. 1873-3492 0009-8981 10.1016/j.cca.2016.08.002 2-s2.0-84980319722 2-s2.0-84980319722.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinica Chimica Acta 1,102 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
110-113 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128890738049024 |