The GATA3 gene is involved in leprosy susceptibility in Brazilian patients

Detalhes bibliográficos
Autor(a) principal: Medeiros, Priscila
Data de Publicação: 2016
Outros Autores: Silva, Weber Laurentino da, Gimenez, Bruna Beatriz de Oliveira, Vallezi, Karen Bastos, Moraes, Milton Ozório, Souza, Vânia Niéto Brito de, Latini, Ana Carla Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://hdl.handle.net/11449/217914
Resumo: Leprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association. Here, we tested tag single nucleotide polymorphisms at GATA3 in two case-control samples from Brazil comprising a total of 1633 individuals using stepwise strategy. The A allele of rs10905284 marker was associated with leprosy resistance. Then, a functional analysis was conducted and showed that individuals carrying AA genotype express higher levels of GATA-3 protein in lymphocytes. So, we confirmed that the rs10905284 is a locus associated to leprosy and influences the levels of this transcription factor in the Brazilian population.
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spelling The GATA3 gene is involved in leprosy susceptibility in Brazilian patientsAssociation studyGATA-3 transcription factorGATA3LeprosyPolymorphismsrs10905284Leprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association. Here, we tested tag single nucleotide polymorphisms at GATA3 in two case-control samples from Brazil comprising a total of 1633 individuals using stepwise strategy. The A allele of rs10905284 marker was associated with leprosy resistance. Then, a functional analysis was conducted and showed that individuals carrying AA genotype express higher levels of GATA-3 protein in lymphocytes. So, we confirmed that the rs10905284 is a locus associated to leprosy and influences the levels of this transcription factor in the Brazilian population.OutraConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Versão final do editorInstituto Lauro de Souza LimaFaculdade de Medicina de Botucatu - FMBFAPESP: 2009/16873-8FAPESP: 576051/2008-0FAPESP: 2014/04143-3ScienceDirectUniversidade Estadual Paulista (Unesp)Medeiros, PriscilaSilva, Weber Laurentino daGimenez, Bruna Beatriz de OliveiraVallezi, Karen BastosMoraes, Milton OzórioSouza, Vânia Niéto Brito deLatini, Ana Carla Pereira2022-04-19T12:50:24Z2022-04-19T12:50:24Z2016-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11449/21791410.1016/j.meegid.2016.01.01538663615467850800000-0002-0853-4715engInfection, Genetics and Evolutioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESP2024-08-15T15:22:31Zoai:repositorio.unesp.br:11449/217914Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:22:31Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The GATA3 gene is involved in leprosy susceptibility in Brazilian patients
title The GATA3 gene is involved in leprosy susceptibility in Brazilian patients
spellingShingle The GATA3 gene is involved in leprosy susceptibility in Brazilian patients
Medeiros, Priscila
Association study
GATA-3 transcription factor
GATA3
Leprosy
Polymorphisms
rs10905284
title_short The GATA3 gene is involved in leprosy susceptibility in Brazilian patients
title_full The GATA3 gene is involved in leprosy susceptibility in Brazilian patients
title_fullStr The GATA3 gene is involved in leprosy susceptibility in Brazilian patients
title_full_unstemmed The GATA3 gene is involved in leprosy susceptibility in Brazilian patients
title_sort The GATA3 gene is involved in leprosy susceptibility in Brazilian patients
author Medeiros, Priscila
author_facet Medeiros, Priscila
Silva, Weber Laurentino da
Gimenez, Bruna Beatriz de Oliveira
Vallezi, Karen Bastos
Moraes, Milton Ozório
Souza, Vânia Niéto Brito de
Latini, Ana Carla Pereira
author_role author
author2 Silva, Weber Laurentino da
Gimenez, Bruna Beatriz de Oliveira
Vallezi, Karen Bastos
Moraes, Milton Ozório
Souza, Vânia Niéto Brito de
Latini, Ana Carla Pereira
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Medeiros, Priscila
Silva, Weber Laurentino da
Gimenez, Bruna Beatriz de Oliveira
Vallezi, Karen Bastos
Moraes, Milton Ozório
Souza, Vânia Niéto Brito de
Latini, Ana Carla Pereira
dc.subject.por.fl_str_mv Association study
GATA-3 transcription factor
GATA3
Leprosy
Polymorphisms
rs10905284
topic Association study
GATA-3 transcription factor
GATA3
Leprosy
Polymorphisms
rs10905284
description Leprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association. Here, we tested tag single nucleotide polymorphisms at GATA3 in two case-control samples from Brazil comprising a total of 1633 individuals using stepwise strategy. The A allele of rs10905284 marker was associated with leprosy resistance. Then, a functional analysis was conducted and showed that individuals carrying AA genotype express higher levels of GATA-3 protein in lymphocytes. So, we confirmed that the rs10905284 is a locus associated to leprosy and influences the levels of this transcription factor in the Brazilian population.
publishDate 2016
dc.date.none.fl_str_mv 2016-04
2022-04-19T12:50:24Z
2022-04-19T12:50:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/11449/217914
10.1016/j.meegid.2016.01.015
3866361546785080
0000-0002-0853-4715
url http://hdl.handle.net/11449/217914
identifier_str_mv 10.1016/j.meegid.2016.01.015
3866361546785080
0000-0002-0853-4715
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Infection, Genetics and Evolution
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ScienceDirect
publisher.none.fl_str_mv ScienceDirect
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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