Influência de plantas medicinais, citadas por uma comunidade rural, sobre o metabolismo de colesterol, em coelhos com hipercolesterolemia experimental

• Autor(a) principal: Freitas, Bruna Baptista de [UNESP]
• Data de Publicação: 2013
• Outros Autores: Conz, Camila [UNESP], Tardivo, Antonio Carlos de Barros [UNESP], Torres, Roseli B., Silva, Sandra Maria Pereira da [UNESP], Ming, Lin Chau [UNESP], Alves, Maria José Queiroz de Freitas [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://pgsskroton.com.br/seer//index.php/RPInF/article/view/36; http://hdl.handle.net/11449/140834
• topic: Baccharis trimera; Ageratum conyzoides L.; Herreria salsaparrilha; Hypercholesterolemia; Rabbits; Baccharis trimera; Ageratum conyzoides L.; Herreria salsaparrilha; Hipercolesterolemia; Coelho

Among the research that medicinal plants and their therapeutic properties are the focus, ethnobotany elucidates issues related to the criteria and tools that leads to the choice of studying certain medicinal species. The St. John's wort, carqueja and sarsaparilha were cited by the community of Bairro dos Marins, Piquete city, as being good for the treatment of hyperlipidemia. This study aimed at assessing the possible effects of these plants on plasma cholesterol in rabbits with experimental hypercholesterolemia. The animals were divided into four groups, which received diet and treatment specific to each group: G1 = treatment with St. John’s wort (n = 3), G2 = carqueja treatment (n = 3), G3 = treatment with sarsaparilla (n = 3) and G4 = supplemented group (n = 3). Weekly, after 14h fasting, blood was collected by marginal ear vein and the plasma was used to dose cholesterol. The experimental protocol was divided into three periods: 1st period - feeding rabbits with normal chow (4 groups), to assess their basal cholesterol; 2nd period - all rabbits (4 groups) received supplemented chow with egg yolk and oil to develop the hypercholesterolemia and 3rd period - according to treatment groups. Cholesterol in the first period was 38.75 ± 6.6 mg/dL; in the 2nd period there was a significant increase in plasma cholesterol level (in 4 groups) - always above 300mg/dL. With regard to treatment, the St. John's wort significantly reduced the level of hypercholesterolemia; carqueja and sarsaparilha didn’t promote cholesterol reduction, but prevented disease progression, which was recorded in group 4 (only supplementation, untreated). It is concluded that St. John's wort has bioactive principles that promotes the reduction of plasma cholesterol in animals with induced hypercholesterolemia.