Tratamento de queloides usando radioterapia pósoperatória com elétrons: Estudo comparativo e randomizado com dois esquemas
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/227182 |
Resumo: | Introduction: While several keloid treatment modalities exist, they all offer disappointing results when performed in isolation. The combination of surgical excision and post-operative irradiation with electron beams is effective in improving the quality of scars and reducing the recurrence rate of the condition. Objective: To assess, on a comparative basis, the prospects for cure, and also side effects in the irradiated areas of two treatment methods using electron beams.Methods: A prospective, comparative and randomized clinical study was carried out at the Faculdade de Medicina de Botucatu-UNESP, in Botucatu (SP), Brazil, between 2008 and 2010. The study included patients who were post-operative after their treatment for the resection of keloids. The study population was divided into groups G1 and G2, having received radiotherapy treatment with electrons from a linear accelerator at 30 Gy/10 fractions and 32 Gy/16 fractions, respectively.The patients were followed up with for 18 months. Results were assessed through the observation of two independent evaluators and the distribution of a questionnaire to study participants. Results: Forty-three patients were investigated (21in G1 and 22 in G2). 52.4% showed good results in G1, with a recurrence rate of 47.6%. In G2, 91% showed good results, with a 9% recurrence rate. Conclusion: The 32 Gy/16 fractions method was proved to be superior to the 30 Gy/10 fractions method, resulting in a better therapeutic response and fewer side effects. |
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Tratamento de queloides usando radioterapia pósoperatória com elétrons: Estudo comparativo e randomizado com dois esquemasKeloid treatment using postoperative radiotherapy with electron beams: A comparative randomized study of two methodsElectronsKeloidRadiotherapyIntroduction: While several keloid treatment modalities exist, they all offer disappointing results when performed in isolation. The combination of surgical excision and post-operative irradiation with electron beams is effective in improving the quality of scars and reducing the recurrence rate of the condition. Objective: To assess, on a comparative basis, the prospects for cure, and also side effects in the irradiated areas of two treatment methods using electron beams.Methods: A prospective, comparative and randomized clinical study was carried out at the Faculdade de Medicina de Botucatu-UNESP, in Botucatu (SP), Brazil, between 2008 and 2010. The study included patients who were post-operative after their treatment for the resection of keloids. The study population was divided into groups G1 and G2, having received radiotherapy treatment with electrons from a linear accelerator at 30 Gy/10 fractions and 32 Gy/16 fractions, respectively.The patients were followed up with for 18 months. Results were assessed through the observation of two independent evaluators and the distribution of a questionnaire to study participants. Results: Forty-three patients were investigated (21in G1 and 22 in G2). 52.4% showed good results in G1, with a recurrence rate of 47.6%. In G2, 91% showed good results, with a 9% recurrence rate. Conclusion: The 32 Gy/16 fractions method was proved to be superior to the 30 Gy/10 fractions method, resulting in a better therapeutic response and fewer side effects.Serviço de Radioterapia do Hospital das Clínicas Faculdade de Medicina de Botucatu Universidade Estadual Paulista (Unesp), Botucatu (SP)Departamento de Oftalmologia da Faculdade de Medicina Botucatu da Universidade Estadual Paulista (Unesp), Botucatu (SP)Departamento de Dermatologia e Radioterapia Faculdade de Medicina de Botucatu da Universidade Estadual Paulista (Unesp), Botucatu (SP)Departamento de Bioestatística Instituto Básico Universidade Estadual Paulista (Unesp), Botucatu (SP)Faculdade de Medicina Universidade José do Rosário Vellano (Unifenas), Alfenas (MG)Serviço de Radioterapia do Hospital das Clínicas Faculdade de Medicina de Botucatu Universidade Estadual Paulista (Unesp), Botucatu (SP)Departamento de Oftalmologia da Faculdade de Medicina Botucatu da Universidade Estadual Paulista (Unesp), Botucatu (SP)Departamento de Dermatologia e Radioterapia Faculdade de Medicina de Botucatu da Universidade Estadual Paulista (Unesp), Botucatu (SP)Departamento de Bioestatística Instituto Básico Universidade Estadual Paulista (Unesp), Botucatu (SP)Universidade Estadual Paulista (UNESP)Universidade José do Rosário Vellano (Unifenas)de Oliveira Junior, Batista [UNESP]Schellini, Silvana Artioli [UNESP]Lastória, Joel Carlos [UNESP]de Carvalho, Lídia Raquel [UNESP]Stolf, Hamilton Ometto [UNESP]de Oliveira, Ana Laura Paludetto2022-04-29T07:11:51Z2022-04-29T07:11:51Z2013-06-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16-26Surgical and Cosmetic Dermatology, v. 5, n. 1, p. 16-26, 2013.1984-55101984-8773http://hdl.handle.net/11449/2271822-s2.0-84879300881Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporSurgical and Cosmetic Dermatologyinfo:eu-repo/semantics/openAccess2022-04-29T07:11:52Zoai:repositorio.unesp.br:11449/227182Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T07:11:52Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Tratamento de queloides usando radioterapia pósoperatória com elétrons: Estudo comparativo e randomizado com dois esquemas Keloid treatment using postoperative radiotherapy with electron beams: A comparative randomized study of two methods |
title |
Tratamento de queloides usando radioterapia pósoperatória com elétrons: Estudo comparativo e randomizado com dois esquemas |
spellingShingle |
Tratamento de queloides usando radioterapia pósoperatória com elétrons: Estudo comparativo e randomizado com dois esquemas de Oliveira Junior, Batista [UNESP] Electrons Keloid Radiotherapy |
title_short |
Tratamento de queloides usando radioterapia pósoperatória com elétrons: Estudo comparativo e randomizado com dois esquemas |
title_full |
Tratamento de queloides usando radioterapia pósoperatória com elétrons: Estudo comparativo e randomizado com dois esquemas |
title_fullStr |
Tratamento de queloides usando radioterapia pósoperatória com elétrons: Estudo comparativo e randomizado com dois esquemas |
title_full_unstemmed |
Tratamento de queloides usando radioterapia pósoperatória com elétrons: Estudo comparativo e randomizado com dois esquemas |
title_sort |
Tratamento de queloides usando radioterapia pósoperatória com elétrons: Estudo comparativo e randomizado com dois esquemas |
author |
de Oliveira Junior, Batista [UNESP] |
author_facet |
de Oliveira Junior, Batista [UNESP] Schellini, Silvana Artioli [UNESP] Lastória, Joel Carlos [UNESP] de Carvalho, Lídia Raquel [UNESP] Stolf, Hamilton Ometto [UNESP] de Oliveira, Ana Laura Paludetto |
author_role |
author |
author2 |
Schellini, Silvana Artioli [UNESP] Lastória, Joel Carlos [UNESP] de Carvalho, Lídia Raquel [UNESP] Stolf, Hamilton Ometto [UNESP] de Oliveira, Ana Laura Paludetto |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Universidade José do Rosário Vellano (Unifenas) |
dc.contributor.author.fl_str_mv |
de Oliveira Junior, Batista [UNESP] Schellini, Silvana Artioli [UNESP] Lastória, Joel Carlos [UNESP] de Carvalho, Lídia Raquel [UNESP] Stolf, Hamilton Ometto [UNESP] de Oliveira, Ana Laura Paludetto |
dc.subject.por.fl_str_mv |
Electrons Keloid Radiotherapy |
topic |
Electrons Keloid Radiotherapy |
description |
Introduction: While several keloid treatment modalities exist, they all offer disappointing results when performed in isolation. The combination of surgical excision and post-operative irradiation with electron beams is effective in improving the quality of scars and reducing the recurrence rate of the condition. Objective: To assess, on a comparative basis, the prospects for cure, and also side effects in the irradiated areas of two treatment methods using electron beams.Methods: A prospective, comparative and randomized clinical study was carried out at the Faculdade de Medicina de Botucatu-UNESP, in Botucatu (SP), Brazil, between 2008 and 2010. The study included patients who were post-operative after their treatment for the resection of keloids. The study population was divided into groups G1 and G2, having received radiotherapy treatment with electrons from a linear accelerator at 30 Gy/10 fractions and 32 Gy/16 fractions, respectively.The patients were followed up with for 18 months. Results were assessed through the observation of two independent evaluators and the distribution of a questionnaire to study participants. Results: Forty-three patients were investigated (21in G1 and 22 in G2). 52.4% showed good results in G1, with a recurrence rate of 47.6%. In G2, 91% showed good results, with a 9% recurrence rate. Conclusion: The 32 Gy/16 fractions method was proved to be superior to the 30 Gy/10 fractions method, resulting in a better therapeutic response and fewer side effects. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-06-28 2022-04-29T07:11:51Z 2022-04-29T07:11:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Surgical and Cosmetic Dermatology, v. 5, n. 1, p. 16-26, 2013. 1984-5510 1984-8773 http://hdl.handle.net/11449/227182 2-s2.0-84879300881 |
identifier_str_mv |
Surgical and Cosmetic Dermatology, v. 5, n. 1, p. 16-26, 2013. 1984-5510 1984-8773 2-s2.0-84879300881 |
url |
http://hdl.handle.net/11449/227182 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Surgical and Cosmetic Dermatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
16-26 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964435364708352 |