The development of resistance to caffeine in Drosophila prosaltans: Productivity and longevity after ten generations of treatment

• Autor(a) principal: Itoyama, M. M. [UNESP]
• Data de Publicação: 1998
• Outros Autores: De Campos Bicudo, H. E.M. [UNESP], Manzato, A. J. [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/224098
• topic: Caffeine; Drosophila; Longevity; Productivity

The productivity of Drosophila prosaltans treated with six concentrations of caffeine (from 50 μg/ml to 2,500 μg/ml of culture medium) during ten generations (∼8 months) decreased in a dosage dependent manner in every generation, but at the end of the treatment the flies in all experiments recovered normal productivity, except for those treated with 2,500 μg/ml. Longevity in the tenth generation was significantly reduced in males and females only in the 2,500 μg/ml dosage, with males being much more affected than females. In a previous study in which the treatment was done in a single generation, productivity exhibited only a partial recovery when the treatment ceased and longevity was significantly reduced in 1,500 μg/ml dosages. The hypothesis of selection occurring in ten generations leading to recovery in productivity and to a reduction in the processes which cause a decrease in longevity is being considered.