Proteinuria predicts relapse in adolescent and adult minimal change disease

Detalhes bibliográficos
Autor(a) principal: Dias, Cristiane Bitencourt
Data de Publicação: 2012
Outros Autores: Pinheiro, Cilene Carlos, Silva, Vanessa dos Santos [UNESP], Hagemann, Rodrigo [UNESP], Barros, Rui Toledo, Woronik, Viktoria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.6061/clinics/2012(11)08
http://hdl.handle.net/11449/41783
Resumo: OBJECTIVE: This study sought to outline the clinical and laboratory characteristics of minimal change disease in adolescents and adults and establish the clinical and laboratory characteristics of relapsing and non-relapsing patients.METHODS: We retrospectively evaluated patients with confirmed diagnoses of minimal change disease by renal biopsy from 1979 to 2009; the patients were aged >13 years and had minimum 1-year follow-ups.RESULTS: Sixty-three patients with a median age (at diagnosis) of 34 (23-49) years were studied, including 23 males and 40 females. At diagnosis, eight (12.7%) patients presented with microscopic hematuria, 17 (27%) with hypertension and 17 (27%) with acute kidney injury. After the initial treatment, 55 (87.3%) patients showed complete remission, six (9.5%) showed partial remission and two (3.1%) were nonresponders. Disease relapse was observed in 34 (54%) patients who were initial responders (n = 61). In a comparison between the relapsing patients (n = 34) and the non-relapsing patients (n = 27), only proteinuria at diagnosis showed any significant difference (8.8 (7.1-12.0) vs. 6.0 (3.6-7.3) g/day, respectively, p = 0.001). Proteinuria greater than 7 g/day at the initial screening was associated with relapsing disease.CONCLUSIONS: In conclusion, minimal change disease in adults may sometimes present concurrently with hematuria, hypertension, and acute kidney injury. The relapsing pattern in our patients was associated with basal proteinuria over 7 g/day.
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spelling Proteinuria predicts relapse in adolescent and adult minimal change diseaseMinimal Change DiseaseAdultsRelapseProteinuriaOBJECTIVE: This study sought to outline the clinical and laboratory characteristics of minimal change disease in adolescents and adults and establish the clinical and laboratory characteristics of relapsing and non-relapsing patients.METHODS: We retrospectively evaluated patients with confirmed diagnoses of minimal change disease by renal biopsy from 1979 to 2009; the patients were aged >13 years and had minimum 1-year follow-ups.RESULTS: Sixty-three patients with a median age (at diagnosis) of 34 (23-49) years were studied, including 23 males and 40 females. At diagnosis, eight (12.7%) patients presented with microscopic hematuria, 17 (27%) with hypertension and 17 (27%) with acute kidney injury. After the initial treatment, 55 (87.3%) patients showed complete remission, six (9.5%) showed partial remission and two (3.1%) were nonresponders. Disease relapse was observed in 34 (54%) patients who were initial responders (n = 61). In a comparison between the relapsing patients (n = 34) and the non-relapsing patients (n = 27), only proteinuria at diagnosis showed any significant difference (8.8 (7.1-12.0) vs. 6.0 (3.6-7.3) g/day, respectively, p = 0.001). Proteinuria greater than 7 g/day at the initial screening was associated with relapsing disease.CONCLUSIONS: In conclusion, minimal change disease in adults may sometimes present concurrently with hematuria, hypertension, and acute kidney injury. The relapsing pattern in our patients was associated with basal proteinuria over 7 g/day.Univ São Paulo, Fac Med, Hosp Clin, Div Nephrol, São Paulo, BrazilUniv Estadual Paulista, Hosp Clin, Fac Botucatu, Dept Internal Med, São Paulo, BrazilUniv Estadual Paulista, Hosp Clin, Fac Botucatu, Dept Internal Med, São Paulo, BrazilUniversidade de São Paulo (USP), Hospital das ClínicasUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Dias, Cristiane BitencourtPinheiro, Cilene CarlosSilva, Vanessa dos Santos [UNESP]Hagemann, Rodrigo [UNESP]Barros, Rui ToledoWoronik, Viktoria2014-05-20T15:33:02Z2014-05-20T15:33:02Z2012-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1271-1274http://dx.doi.org/10.6061/clinics/2012(11)08Clinics. São Paulo: Hospital Clinicas, Univ São Paulo, v. 67, n. 11, p. 1271-1274, 2012.1807-5932http://hdl.handle.net/11449/4178310.6061/clinics/2012(11)08WOS:000311534900008Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinics1.2450,536info:eu-repo/semantics/openAccess2024-08-14T17:23:09Zoai:repositorio.unesp.br:11449/41783Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:09Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Proteinuria predicts relapse in adolescent and adult minimal change disease
title Proteinuria predicts relapse in adolescent and adult minimal change disease
spellingShingle Proteinuria predicts relapse in adolescent and adult minimal change disease
Dias, Cristiane Bitencourt
Minimal Change Disease
Adults
Relapse
Proteinuria
title_short Proteinuria predicts relapse in adolescent and adult minimal change disease
title_full Proteinuria predicts relapse in adolescent and adult minimal change disease
title_fullStr Proteinuria predicts relapse in adolescent and adult minimal change disease
title_full_unstemmed Proteinuria predicts relapse in adolescent and adult minimal change disease
title_sort Proteinuria predicts relapse in adolescent and adult minimal change disease
author Dias, Cristiane Bitencourt
author_facet Dias, Cristiane Bitencourt
Pinheiro, Cilene Carlos
Silva, Vanessa dos Santos [UNESP]
Hagemann, Rodrigo [UNESP]
Barros, Rui Toledo
Woronik, Viktoria
author_role author
author2 Pinheiro, Cilene Carlos
Silva, Vanessa dos Santos [UNESP]
Hagemann, Rodrigo [UNESP]
Barros, Rui Toledo
Woronik, Viktoria
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Dias, Cristiane Bitencourt
Pinheiro, Cilene Carlos
Silva, Vanessa dos Santos [UNESP]
Hagemann, Rodrigo [UNESP]
Barros, Rui Toledo
Woronik, Viktoria
dc.subject.por.fl_str_mv Minimal Change Disease
Adults
Relapse
Proteinuria
topic Minimal Change Disease
Adults
Relapse
Proteinuria
description OBJECTIVE: This study sought to outline the clinical and laboratory characteristics of minimal change disease in adolescents and adults and establish the clinical and laboratory characteristics of relapsing and non-relapsing patients.METHODS: We retrospectively evaluated patients with confirmed diagnoses of minimal change disease by renal biopsy from 1979 to 2009; the patients were aged >13 years and had minimum 1-year follow-ups.RESULTS: Sixty-three patients with a median age (at diagnosis) of 34 (23-49) years were studied, including 23 males and 40 females. At diagnosis, eight (12.7%) patients presented with microscopic hematuria, 17 (27%) with hypertension and 17 (27%) with acute kidney injury. After the initial treatment, 55 (87.3%) patients showed complete remission, six (9.5%) showed partial remission and two (3.1%) were nonresponders. Disease relapse was observed in 34 (54%) patients who were initial responders (n = 61). In a comparison between the relapsing patients (n = 34) and the non-relapsing patients (n = 27), only proteinuria at diagnosis showed any significant difference (8.8 (7.1-12.0) vs. 6.0 (3.6-7.3) g/day, respectively, p = 0.001). Proteinuria greater than 7 g/day at the initial screening was associated with relapsing disease.CONCLUSIONS: In conclusion, minimal change disease in adults may sometimes present concurrently with hematuria, hypertension, and acute kidney injury. The relapsing pattern in our patients was associated with basal proteinuria over 7 g/day.
publishDate 2012
dc.date.none.fl_str_mv 2012-01-01
2014-05-20T15:33:02Z
2014-05-20T15:33:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.6061/clinics/2012(11)08
Clinics. São Paulo: Hospital Clinicas, Univ São Paulo, v. 67, n. 11, p. 1271-1274, 2012.
1807-5932
http://hdl.handle.net/11449/41783
10.6061/clinics/2012(11)08
WOS:000311534900008
url http://dx.doi.org/10.6061/clinics/2012(11)08
http://hdl.handle.net/11449/41783
identifier_str_mv Clinics. São Paulo: Hospital Clinicas, Univ São Paulo, v. 67, n. 11, p. 1271-1274, 2012.
1807-5932
10.6061/clinics/2012(11)08
WOS:000311534900008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinics
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1271-1274
dc.publisher.none.fl_str_mv Universidade de São Paulo (USP), Hospital das Clínicas
publisher.none.fl_str_mv Universidade de São Paulo (USP), Hospital das Clínicas
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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