Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.lfs.2018.09.056 http://hdl.handle.net/11449/188206 |
Resumo: | Aim: This study aimed to investigate the effects of melatonin (ME) on insulin resistance (IR) and signaling (IS), proinflammatory cytokine levels, and lipid profiles in pinealectomyzed (PNX) rats with periodontal disease (PD). Main methods: One hundred and forty-four rats (age = 40 days) were distributed into 8 groups: 1) control (CN); 2) PD only; 3) PNX only; 4) PNX and PD (PNXPD); 5) CN treated with ME (CNM); 6) PD treated with ME (PDM); 7) PNX treated with ME(PNXM); 8) PNX and PD treated with ME(PNXPDM). The PNX groups were subjected to pinealectomy at 40 and at 60 days of age. The animals were then subjected to PD induction in the mandibular first molars. After PD induction, the ME replacement therapy (MERT-5 mg/kg body weight) was performed using water for 28 days. After this period, the plasma concentration of glucose, insulin, TNF, IL-6, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, and VLDL-cholesterol and the HOMA-IR index were determined. Akt serine phosphorylation status in the white adipose tissue, gastrocnemius muscle, and rat liver were also evaluated. Key findings: PD, PNX, and PNXPD groups showed an increase in IR with elevated plasma levels of insulin and TNF compared to CN group. PNX and PNXPD groups presented alteration in lipid profile compared to CN group. MERT improved all of the analyzed parameters. No difference was observed in the IS among different groups. Significance: The results suggest that MERT efficiently prevents IR, improves lipid profile, and increases plasma levels of insulin and TNF in PD and PNX rats. |
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Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal diseaseCholesterolInsulin resistanceMelatoninPeriodontal diseasesPineal glandAim: This study aimed to investigate the effects of melatonin (ME) on insulin resistance (IR) and signaling (IS), proinflammatory cytokine levels, and lipid profiles in pinealectomyzed (PNX) rats with periodontal disease (PD). Main methods: One hundred and forty-four rats (age = 40 days) were distributed into 8 groups: 1) control (CN); 2) PD only; 3) PNX only; 4) PNX and PD (PNXPD); 5) CN treated with ME (CNM); 6) PD treated with ME (PDM); 7) PNX treated with ME(PNXM); 8) PNX and PD treated with ME(PNXPDM). The PNX groups were subjected to pinealectomy at 40 and at 60 days of age. The animals were then subjected to PD induction in the mandibular first molars. After PD induction, the ME replacement therapy (MERT-5 mg/kg body weight) was performed using water for 28 days. After this period, the plasma concentration of glucose, insulin, TNF, IL-6, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, and VLDL-cholesterol and the HOMA-IR index were determined. Akt serine phosphorylation status in the white adipose tissue, gastrocnemius muscle, and rat liver were also evaluated. Key findings: PD, PNX, and PNXPD groups showed an increase in IR with elevated plasma levels of insulin and TNF compared to CN group. PNX and PNXPD groups presented alteration in lipid profile compared to CN group. MERT improved all of the analyzed parameters. No difference was observed in the IS among different groups. Significance: The results suggest that MERT efficiently prevents IR, improves lipid profile, and increases plasma levels of insulin and TNF in PD and PNX rats.Programa de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisPreventive and Social Dentistry Post-Graduation Program School of Dentistry of Araçatuba São Paulo State University (UNESP)Department of Basic Sciences School of Dentistry of Araçatuba São Paulo State University (UNESP)Institute of Biosciences of Botucatu São Paulo State UniversityPreventive and Social Dentistry Post-Graduation Program School of Dentistry of Araçatuba São Paulo State University (UNESP)Department of Basic Sciences School of Dentistry of Araçatuba São Paulo State University (UNESP)Institute of Biosciences of Botucatu São Paulo State UniversityPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisUniversidade Estadual Paulista (Unesp)Santos, Rodrigo Martins dos [UNESP]Marani, Fernando [UNESP]Chiba, Fernando Yamamoto [UNESP]Mattera, Maria Sara de Lima Coutinho [UNESP]Tsosura, Thais Verônica Saori [UNESP]Tessarin, Gestter Willian Lattari [UNESP]Pereira, Renato Felipe [UNESP]Belardi, Bianca Elvira [UNESP]Pinheiro, Beatriz Costa E Silva [UNESP]Sumida, Doris Hissako [UNESP]2019-10-06T16:00:43Z2019-10-06T16:00:43Z2018-11-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article32-39http://dx.doi.org/10.1016/j.lfs.2018.09.056Life Sciences, v. 213, p. 32-39.1879-06310024-3205http://hdl.handle.net/11449/18820610.1016/j.lfs.2018.09.0562-s2.0-85054849268Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengLife Sciencesinfo:eu-repo/semantics/openAccess2021-10-23T10:11:29Zoai:repositorio.unesp.br:11449/188206Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:50:47.302450Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease |
title |
Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease |
spellingShingle |
Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease Santos, Rodrigo Martins dos [UNESP] Cholesterol Insulin resistance Melatonin Periodontal diseases Pineal gland |
title_short |
Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease |
title_full |
Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease |
title_fullStr |
Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease |
title_full_unstemmed |
Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease |
title_sort |
Melatonin promotes reduction in TNF levels and improves the lipid profile and insulin sensitivity in pinealectomized rats with periodontal disease |
author |
Santos, Rodrigo Martins dos [UNESP] |
author_facet |
Santos, Rodrigo Martins dos [UNESP] Marani, Fernando [UNESP] Chiba, Fernando Yamamoto [UNESP] Mattera, Maria Sara de Lima Coutinho [UNESP] Tsosura, Thais Verônica Saori [UNESP] Tessarin, Gestter Willian Lattari [UNESP] Pereira, Renato Felipe [UNESP] Belardi, Bianca Elvira [UNESP] Pinheiro, Beatriz Costa E Silva [UNESP] Sumida, Doris Hissako [UNESP] |
author_role |
author |
author2 |
Marani, Fernando [UNESP] Chiba, Fernando Yamamoto [UNESP] Mattera, Maria Sara de Lima Coutinho [UNESP] Tsosura, Thais Verônica Saori [UNESP] Tessarin, Gestter Willian Lattari [UNESP] Pereira, Renato Felipe [UNESP] Belardi, Bianca Elvira [UNESP] Pinheiro, Beatriz Costa E Silva [UNESP] Sumida, Doris Hissako [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Programa de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFis Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Santos, Rodrigo Martins dos [UNESP] Marani, Fernando [UNESP] Chiba, Fernando Yamamoto [UNESP] Mattera, Maria Sara de Lima Coutinho [UNESP] Tsosura, Thais Verônica Saori [UNESP] Tessarin, Gestter Willian Lattari [UNESP] Pereira, Renato Felipe [UNESP] Belardi, Bianca Elvira [UNESP] Pinheiro, Beatriz Costa E Silva [UNESP] Sumida, Doris Hissako [UNESP] |
dc.subject.por.fl_str_mv |
Cholesterol Insulin resistance Melatonin Periodontal diseases Pineal gland |
topic |
Cholesterol Insulin resistance Melatonin Periodontal diseases Pineal gland |
description |
Aim: This study aimed to investigate the effects of melatonin (ME) on insulin resistance (IR) and signaling (IS), proinflammatory cytokine levels, and lipid profiles in pinealectomyzed (PNX) rats with periodontal disease (PD). Main methods: One hundred and forty-four rats (age = 40 days) were distributed into 8 groups: 1) control (CN); 2) PD only; 3) PNX only; 4) PNX and PD (PNXPD); 5) CN treated with ME (CNM); 6) PD treated with ME (PDM); 7) PNX treated with ME(PNXM); 8) PNX and PD treated with ME(PNXPDM). The PNX groups were subjected to pinealectomy at 40 and at 60 days of age. The animals were then subjected to PD induction in the mandibular first molars. After PD induction, the ME replacement therapy (MERT-5 mg/kg body weight) was performed using water for 28 days. After this period, the plasma concentration of glucose, insulin, TNF, IL-6, triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol, and VLDL-cholesterol and the HOMA-IR index were determined. Akt serine phosphorylation status in the white adipose tissue, gastrocnemius muscle, and rat liver were also evaluated. Key findings: PD, PNX, and PNXPD groups showed an increase in IR with elevated plasma levels of insulin and TNF compared to CN group. PNX and PNXPD groups presented alteration in lipid profile compared to CN group. MERT improved all of the analyzed parameters. No difference was observed in the IS among different groups. Significance: The results suggest that MERT efficiently prevents IR, improves lipid profile, and increases plasma levels of insulin and TNF in PD and PNX rats. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-11-15 2019-10-06T16:00:43Z 2019-10-06T16:00:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.lfs.2018.09.056 Life Sciences, v. 213, p. 32-39. 1879-0631 0024-3205 http://hdl.handle.net/11449/188206 10.1016/j.lfs.2018.09.056 2-s2.0-85054849268 |
url |
http://dx.doi.org/10.1016/j.lfs.2018.09.056 http://hdl.handle.net/11449/188206 |
identifier_str_mv |
Life Sciences, v. 213, p. 32-39. 1879-0631 0024-3205 10.1016/j.lfs.2018.09.056 2-s2.0-85054849268 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Life Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
32-39 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128989507616768 |