Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1097/MD.0000000000016376 http://hdl.handle.net/11449/190561 |
Resumo: | The HIV subtype B is the most frequent in Brazil. The HIV subtype B' codes the amino acids glicine-tryptophan-glicine (GWG) instead of glicine-proline-glicine on the tip of gp120 V3 loop. This variant was associated to a slower HIV progression in mono-infected patients; however, there is no information in coinfected patients. This study evaluated the infection progression of HIV variant B' on the hepatitis C virus presence. RNA isolated from plasma of the 601 infected patients were used to human immunodeficiency virus (HIV) subtyping and to classify the virus according their syncytium-inducing ability. The HIV infection progression was evaluated by clinical and laboratorial data. The results showed a significant association between HIV B' variant and CD4 count and time of AIDS in HIV mono-infected patients. Notwithstanding the fact that we did not find a direct association between GWG variant and AIDS and in HIV coinfected patients no mitigating effect due to GWG presence was found. We did observe that the association between GWG variant and CD4 counts is lost in coinfected patients. This is first work showing influence of the HIV GWG variant in coinfected patients. Nevertheless, the presence of the GWG variant can indicate a better prognostic in the mono-infected patients. |
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spelling |
Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patientsThe HIV subtype B is the most frequent in Brazil. The HIV subtype B' codes the amino acids glicine-tryptophan-glicine (GWG) instead of glicine-proline-glicine on the tip of gp120 V3 loop. This variant was associated to a slower HIV progression in mono-infected patients; however, there is no information in coinfected patients. This study evaluated the infection progression of HIV variant B' on the hepatitis C virus presence. RNA isolated from plasma of the 601 infected patients were used to human immunodeficiency virus (HIV) subtyping and to classify the virus according their syncytium-inducing ability. The HIV infection progression was evaluated by clinical and laboratorial data. The results showed a significant association between HIV B' variant and CD4 count and time of AIDS in HIV mono-infected patients. Notwithstanding the fact that we did not find a direct association between GWG variant and AIDS and in HIV coinfected patients no mitigating effect due to GWG presence was found. We did observe that the association between GWG variant and CD4 counts is lost in coinfected patients. This is first work showing influence of the HIV GWG variant in coinfected patients. Nevertheless, the presence of the GWG variant can indicate a better prognostic in the mono-infected patients.São Paulo State University (Unesp) Medical SchoolMolecular Biology Laboratory Blood Transfusion CenterSão Paulo State University (Unesp) School of AgricultureLaboratory of Molecular Evolution and Bioinformatics (LEMB) Biomedical Sciences Institute University of São Paulo (USP)São Paulo State University (Unesp) Medical SchoolSão Paulo State University (Unesp) School of AgricultureUniversidade Estadual Paulista (Unesp)Blood Transfusion CenterUniversidade de São Paulo (USP)Hebeler-Barbosa, Flavia [UNESP]Massolini, Viviam MilanezWatanabe, Thais [UNESP]Silva, Giovanni Faria [UNESP]Barbosa, Alexandre Naime [UNESP]Simões, Rafael Plana [UNESP]Ferrasi, Adriana Camargo [UNESP]de Andrade Zanotto, Paolo Marinhode Moura Campos Pardini, Maria Inês [UNESP]Grotto, Rejane Maria Tommasini [UNESP]2019-10-06T17:17:15Z2019-10-06T17:17:15Z2019-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlee16376http://dx.doi.org/10.1097/MD.0000000000016376Medicine, v. 98, n. 29, p. e16376-, 2019.1536-5964http://hdl.handle.net/11449/19056110.1097/MD.00000000000163762-s2.0-85070520523186281482759063277884485643265850000-0002-3433-85740000-0002-4035-9486Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedicineinfo:eu-repo/semantics/openAccess2021-10-23T09:20:09Zoai:repositorio.unesp.br:11449/190561Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T09:20:09Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients |
title |
Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients |
spellingShingle |
Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients Hebeler-Barbosa, Flavia [UNESP] |
title_short |
Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients |
title_full |
Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients |
title_fullStr |
Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients |
title_full_unstemmed |
Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients |
title_sort |
Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients |
author |
Hebeler-Barbosa, Flavia [UNESP] |
author_facet |
Hebeler-Barbosa, Flavia [UNESP] Massolini, Viviam Milanez Watanabe, Thais [UNESP] Silva, Giovanni Faria [UNESP] Barbosa, Alexandre Naime [UNESP] Simões, Rafael Plana [UNESP] Ferrasi, Adriana Camargo [UNESP] de Andrade Zanotto, Paolo Marinho de Moura Campos Pardini, Maria Inês [UNESP] Grotto, Rejane Maria Tommasini [UNESP] |
author_role |
author |
author2 |
Massolini, Viviam Milanez Watanabe, Thais [UNESP] Silva, Giovanni Faria [UNESP] Barbosa, Alexandre Naime [UNESP] Simões, Rafael Plana [UNESP] Ferrasi, Adriana Camargo [UNESP] de Andrade Zanotto, Paolo Marinho de Moura Campos Pardini, Maria Inês [UNESP] Grotto, Rejane Maria Tommasini [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Blood Transfusion Center Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Hebeler-Barbosa, Flavia [UNESP] Massolini, Viviam Milanez Watanabe, Thais [UNESP] Silva, Giovanni Faria [UNESP] Barbosa, Alexandre Naime [UNESP] Simões, Rafael Plana [UNESP] Ferrasi, Adriana Camargo [UNESP] de Andrade Zanotto, Paolo Marinho de Moura Campos Pardini, Maria Inês [UNESP] Grotto, Rejane Maria Tommasini [UNESP] |
description |
The HIV subtype B is the most frequent in Brazil. The HIV subtype B' codes the amino acids glicine-tryptophan-glicine (GWG) instead of glicine-proline-glicine on the tip of gp120 V3 loop. This variant was associated to a slower HIV progression in mono-infected patients; however, there is no information in coinfected patients. This study evaluated the infection progression of HIV variant B' on the hepatitis C virus presence. RNA isolated from plasma of the 601 infected patients were used to human immunodeficiency virus (HIV) subtyping and to classify the virus according their syncytium-inducing ability. The HIV infection progression was evaluated by clinical and laboratorial data. The results showed a significant association between HIV B' variant and CD4 count and time of AIDS in HIV mono-infected patients. Notwithstanding the fact that we did not find a direct association between GWG variant and AIDS and in HIV coinfected patients no mitigating effect due to GWG presence was found. We did observe that the association between GWG variant and CD4 counts is lost in coinfected patients. This is first work showing influence of the HIV GWG variant in coinfected patients. Nevertheless, the presence of the GWG variant can indicate a better prognostic in the mono-infected patients. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T17:17:15Z 2019-10-06T17:17:15Z 2019-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1097/MD.0000000000016376 Medicine, v. 98, n. 29, p. e16376-, 2019. 1536-5964 http://hdl.handle.net/11449/190561 10.1097/MD.0000000000016376 2-s2.0-85070520523 1862814827590632 7788448564326585 0000-0002-3433-8574 0000-0002-4035-9486 |
url |
http://dx.doi.org/10.1097/MD.0000000000016376 http://hdl.handle.net/11449/190561 |
identifier_str_mv |
Medicine, v. 98, n. 29, p. e16376-, 2019. 1536-5964 10.1097/MD.0000000000016376 2-s2.0-85070520523 1862814827590632 7788448564326585 0000-0002-3433-8574 0000-0002-4035-9486 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
e16376 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799964856846123008 |