Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1097/GME.0000000000002084 http://hdl.handle.net/11449/248102 |
Resumo: | Objective: The aim of the study is to evaluate the effect of vitamin D supplementation alone on the adipokine profile of postmenopausal women. Methods: In this randomized clinical trial, 160 women were randomized to 2 groups: oral supplementation with 1,000 IU cholecalciferol/d (vitamin D, n = 80) or placebo (PL, n = 80). Women with amenorrhea 12 months or more and aged 50 to 65 years were included. Women with established cardiovascular disease, insulin-dependent diabetes, renal failure, liver diseases, and previous use of menopausal hormone therapy and vitamin D were excluded. The intervention lasted 9 months and serum adiponectin, resistin, and adipsin levels were determined at the start and end of treatment. Intention to treat was adopted as the statistical method using a repeated measures design, followed by Wald's multiple comparison test adjusted for group × time interaction. Results: After 9 months, 25-hydroxyvitamin D concentrations increased from 15.0 ± 7.5 to 27.5 ± 10.4 ng/mL (+45.4%) in the vitamin D group and decreased from 16.9 ± 6. to 13.8 ± 6.0 ng/mL (−18.5%) in the PL group (P < 0.001). In the vitamin D group, there was an increase in adiponectin (+18.6%) and a decrease in resistin (−32.4%, P < 0.05). At the end point, a difference was observed between the PL and vitamin D groups in mean adiponectin and resistin levels (11.5 ± 5.5 vs 18.5 ± 21.8 ng/mL, P = 0.047, and 16.5 ± 3.5 vs 11.7 ± 3.3 ng/mL, P = 0.027, respectively). There were no significant intervention effects on serum adipsin levels. Conclusions: Daily supplementation with 1,000 IU of vitamin D alone was associated with an increase in adiponectin and a decrease in resistin, suggesting a beneficial effect on the adipokine profile of postmenopausal women with vitamin D deficiency. |
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Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trialAdipokinesMenopauseRandomized Clinical TrialVitamin DObjective: The aim of the study is to evaluate the effect of vitamin D supplementation alone on the adipokine profile of postmenopausal women. Methods: In this randomized clinical trial, 160 women were randomized to 2 groups: oral supplementation with 1,000 IU cholecalciferol/d (vitamin D, n = 80) or placebo (PL, n = 80). Women with amenorrhea 12 months or more and aged 50 to 65 years were included. Women with established cardiovascular disease, insulin-dependent diabetes, renal failure, liver diseases, and previous use of menopausal hormone therapy and vitamin D were excluded. The intervention lasted 9 months and serum adiponectin, resistin, and adipsin levels were determined at the start and end of treatment. Intention to treat was adopted as the statistical method using a repeated measures design, followed by Wald's multiple comparison test adjusted for group × time interaction. Results: After 9 months, 25-hydroxyvitamin D concentrations increased from 15.0 ± 7.5 to 27.5 ± 10.4 ng/mL (+45.4%) in the vitamin D group and decreased from 16.9 ± 6. to 13.8 ± 6.0 ng/mL (−18.5%) in the PL group (P < 0.001). In the vitamin D group, there was an increase in adiponectin (+18.6%) and a decrease in resistin (−32.4%, P < 0.05). At the end point, a difference was observed between the PL and vitamin D groups in mean adiponectin and resistin levels (11.5 ± 5.5 vs 18.5 ± 21.8 ng/mL, P = 0.047, and 16.5 ± 3.5 vs 11.7 ± 3.3 ng/mL, P = 0.027, respectively). There were no significant intervention effects on serum adipsin levels. Conclusions: Daily supplementation with 1,000 IU of vitamin D alone was associated with an increase in adiponectin and a decrease in resistin, suggesting a beneficial effect on the adipokine profile of postmenopausal women with vitamin D deficiency.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)The Postgraduate Program in Tocogynecology Botucatu Medical School Sao Paulo State University-UNESP, São PauloDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University-UNESP, São PauloThe Postgraduate Program in Tocogynecology Botucatu Medical School Sao Paulo State University-UNESP, São PauloDepartment of Gynecology and Obstetrics Botucatu Medical School Sao Paulo State University-UNESP, São PauloFAPESP: 2014/19382-3Universidade Estadual Paulista (UNESP)Schmitt, Eneida B. [UNESP]Orsatti, Claudio L. [UNESP]Cangussu, Luciana [UNESP]Bueloni-Dias, Flavia N. [UNESP]Poloni, Priscila F. [UNESP]Spadoto-Dias, Daniel [UNESP]Nahas, Eliana A.P. [UNESP]2023-07-29T13:34:30Z2023-07-29T13:34:30Z2023-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article56-62http://dx.doi.org/10.1097/GME.0000000000002084Menopause, v. 30, n. 1, p. 56-62, 2023.1530-03741072-3714http://hdl.handle.net/11449/24810210.1097/GME.00000000000020842-s2.0-85145022737Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMenopauseinfo:eu-repo/semantics/openAccess2024-08-16T14:06:26Zoai:repositorio.unesp.br:11449/248102Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:06:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trial |
title |
Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trial |
spellingShingle |
Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trial Schmitt, Eneida B. [UNESP] Adipokines Menopause Randomized Clinical Trial Vitamin D |
title_short |
Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trial |
title_full |
Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trial |
title_fullStr |
Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trial |
title_full_unstemmed |
Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trial |
title_sort |
Isolated vitamin D supplementation improves the adipokine profile of postmenopausal women: a randomized clinical trial |
author |
Schmitt, Eneida B. [UNESP] |
author_facet |
Schmitt, Eneida B. [UNESP] Orsatti, Claudio L. [UNESP] Cangussu, Luciana [UNESP] Bueloni-Dias, Flavia N. [UNESP] Poloni, Priscila F. [UNESP] Spadoto-Dias, Daniel [UNESP] Nahas, Eliana A.P. [UNESP] |
author_role |
author |
author2 |
Orsatti, Claudio L. [UNESP] Cangussu, Luciana [UNESP] Bueloni-Dias, Flavia N. [UNESP] Poloni, Priscila F. [UNESP] Spadoto-Dias, Daniel [UNESP] Nahas, Eliana A.P. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Schmitt, Eneida B. [UNESP] Orsatti, Claudio L. [UNESP] Cangussu, Luciana [UNESP] Bueloni-Dias, Flavia N. [UNESP] Poloni, Priscila F. [UNESP] Spadoto-Dias, Daniel [UNESP] Nahas, Eliana A.P. [UNESP] |
dc.subject.por.fl_str_mv |
Adipokines Menopause Randomized Clinical Trial Vitamin D |
topic |
Adipokines Menopause Randomized Clinical Trial Vitamin D |
description |
Objective: The aim of the study is to evaluate the effect of vitamin D supplementation alone on the adipokine profile of postmenopausal women. Methods: In this randomized clinical trial, 160 women were randomized to 2 groups: oral supplementation with 1,000 IU cholecalciferol/d (vitamin D, n = 80) or placebo (PL, n = 80). Women with amenorrhea 12 months or more and aged 50 to 65 years were included. Women with established cardiovascular disease, insulin-dependent diabetes, renal failure, liver diseases, and previous use of menopausal hormone therapy and vitamin D were excluded. The intervention lasted 9 months and serum adiponectin, resistin, and adipsin levels were determined at the start and end of treatment. Intention to treat was adopted as the statistical method using a repeated measures design, followed by Wald's multiple comparison test adjusted for group × time interaction. Results: After 9 months, 25-hydroxyvitamin D concentrations increased from 15.0 ± 7.5 to 27.5 ± 10.4 ng/mL (+45.4%) in the vitamin D group and decreased from 16.9 ± 6. to 13.8 ± 6.0 ng/mL (−18.5%) in the PL group (P < 0.001). In the vitamin D group, there was an increase in adiponectin (+18.6%) and a decrease in resistin (−32.4%, P < 0.05). At the end point, a difference was observed between the PL and vitamin D groups in mean adiponectin and resistin levels (11.5 ± 5.5 vs 18.5 ± 21.8 ng/mL, P = 0.047, and 16.5 ± 3.5 vs 11.7 ± 3.3 ng/mL, P = 0.027, respectively). There were no significant intervention effects on serum adipsin levels. Conclusions: Daily supplementation with 1,000 IU of vitamin D alone was associated with an increase in adiponectin and a decrease in resistin, suggesting a beneficial effect on the adipokine profile of postmenopausal women with vitamin D deficiency. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:34:30Z 2023-07-29T13:34:30Z 2023-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1097/GME.0000000000002084 Menopause, v. 30, n. 1, p. 56-62, 2023. 1530-0374 1072-3714 http://hdl.handle.net/11449/248102 10.1097/GME.0000000000002084 2-s2.0-85145022737 |
url |
http://dx.doi.org/10.1097/GME.0000000000002084 http://hdl.handle.net/11449/248102 |
identifier_str_mv |
Menopause, v. 30, n. 1, p. 56-62, 2023. 1530-0374 1072-3714 10.1097/GME.0000000000002084 2-s2.0-85145022737 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Menopause |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
56-62 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128107393056768 |