Impact of different exercise intensities on pregnant rats and on their offspring
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/0001-3765202020191572 http://hdl.handle.net/11449/207041 |
Resumo: | This study aimed at evaluating the levels of different maternal exercise intensities on maternal and fetal outcomes. Wistar rats were mated and the pregnant rats were distributed into four experimental groups (n = 13 animals/group): Control (Not exercise group-0% of the anaerobic threshold-AT), mild (20%), moderate (80%), and heavy-exercise intensity (140% of AT). These AT were matched to the load of 0, 1, 4 and 7% of the body weight of the animal related to swimming-induced physical intensity. In pregnancy, biomarkers related to maternal blood gases, oxidative stress, metabolism, and reproductive performance, and outcomes of their offspring were analyzed. The mild and moderate-swimming caused no change on implantation, live fetus numbers and oxidative stress status. However, the rats submitted to mild-exercise presented respiratory alkalosis and the heavy-exercise group showed respiratory acidosis. In addition, fetuses of the heavy-exercise dams were smaller for gestational age and lower serum adiponectin levels compared to those of other groups. In conclusion, the moderate-exercise intensity caused beneficial effects for maternal environment and the mild and moderate-exercise presented similar fetal repercussions. Nevertheless, the heavy-exercise intensity caused maternal metabolic alterations that damaged the fetal growth. Therefore, these findings confirm that physical intensity should be carefully conducted to avoid maternal complications and, consequently, compromised fetal repercussions. |
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Impact of different exercise intensities on pregnant rats and on their offspringExercise intensitiesFetusesPregnancySwimmingThis study aimed at evaluating the levels of different maternal exercise intensities on maternal and fetal outcomes. Wistar rats were mated and the pregnant rats were distributed into four experimental groups (n = 13 animals/group): Control (Not exercise group-0% of the anaerobic threshold-AT), mild (20%), moderate (80%), and heavy-exercise intensity (140% of AT). These AT were matched to the load of 0, 1, 4 and 7% of the body weight of the animal related to swimming-induced physical intensity. In pregnancy, biomarkers related to maternal blood gases, oxidative stress, metabolism, and reproductive performance, and outcomes of their offspring were analyzed. The mild and moderate-swimming caused no change on implantation, live fetus numbers and oxidative stress status. However, the rats submitted to mild-exercise presented respiratory alkalosis and the heavy-exercise group showed respiratory acidosis. In addition, fetuses of the heavy-exercise dams were smaller for gestational age and lower serum adiponectin levels compared to those of other groups. In conclusion, the moderate-exercise intensity caused beneficial effects for maternal environment and the mild and moderate-exercise presented similar fetal repercussions. Nevertheless, the heavy-exercise intensity caused maternal metabolic alterations that damaged the fetal growth. Therefore, these findings confirm that physical intensity should be carefully conducted to avoid maternal complications and, consequently, compromised fetal repercussions.Universidade Estadual PaulistaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual Paulista/ UNESP Laboratório de Pesquisa Experimental em Ginecologia e Obstetrícia, Distrito de Rubião Jr, s/nUniversidade Federal do Mato Grosso/UFMT Instituto de Ciências Biológicas e da Saúde Laboratório de Fisiologia dos Sistemas e Toxicologia Reprodutiva, Av. Valdon Varjão, 6390Instituto Nacional de Ciências Médicas e Nutrição Salvador Zubirán Departamento de Biologia Reprodutiva, Belisario Domínguez Secc, 16Universidade Estadual Paulista/ UNESP Laboratório de Pesquisa Experimental em Ginecologia e Obstetrícia, Distrito de Rubião Jr, s/nCAPES: 001FAPESP: 2012/25168-9CNPq: 475073/2013-4Universidade Estadual Paulista (Unesp)Laboratório de Fisiologia dos Sistemas e Toxicologia ReprodutivaInstituto Nacional de Ciências Médicas e Nutrição Salvador ZubiránNetto, Aline O. [UNESP]Dias Macedo, Nathália C. [UNESP]Gallego, Franciane Q. [UNESP]Sinzato, Yuri K. [UNESP]Volpato, Gustavo T.Zambrano, ElenaDamasceno, Débora Cristina [UNESP]2021-06-25T10:48:02Z2021-06-25T10:48:02Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-13application/pdfhttp://dx.doi.org/10.1590/0001-3765202020191572Anais da Academia Brasileira de Ciencias, v. 92, n. 4, p. 1-13, 2020.1678-26900001-3765http://hdl.handle.net/11449/20704110.1590/0001-3765202020191572S0001-376520200007009322-s2.0-85098492308S0001-37652020000700932.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnais da Academia Brasileira de Cienciasinfo:eu-repo/semantics/openAccess2024-08-16T14:07:07Zoai:repositorio.unesp.br:11449/207041Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:07:07Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Impact of different exercise intensities on pregnant rats and on their offspring |
title |
Impact of different exercise intensities on pregnant rats and on their offspring |
spellingShingle |
Impact of different exercise intensities on pregnant rats and on their offspring Netto, Aline O. [UNESP] Exercise intensities Fetuses Pregnancy Swimming |
title_short |
Impact of different exercise intensities on pregnant rats and on their offspring |
title_full |
Impact of different exercise intensities on pregnant rats and on their offspring |
title_fullStr |
Impact of different exercise intensities on pregnant rats and on their offspring |
title_full_unstemmed |
Impact of different exercise intensities on pregnant rats and on their offspring |
title_sort |
Impact of different exercise intensities on pregnant rats and on their offspring |
author |
Netto, Aline O. [UNESP] |
author_facet |
Netto, Aline O. [UNESP] Dias Macedo, Nathália C. [UNESP] Gallego, Franciane Q. [UNESP] Sinzato, Yuri K. [UNESP] Volpato, Gustavo T. Zambrano, Elena Damasceno, Débora Cristina [UNESP] |
author_role |
author |
author2 |
Dias Macedo, Nathália C. [UNESP] Gallego, Franciane Q. [UNESP] Sinzato, Yuri K. [UNESP] Volpato, Gustavo T. Zambrano, Elena Damasceno, Débora Cristina [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Laboratório de Fisiologia dos Sistemas e Toxicologia Reprodutiva Instituto Nacional de Ciências Médicas e Nutrição Salvador Zubirán |
dc.contributor.author.fl_str_mv |
Netto, Aline O. [UNESP] Dias Macedo, Nathália C. [UNESP] Gallego, Franciane Q. [UNESP] Sinzato, Yuri K. [UNESP] Volpato, Gustavo T. Zambrano, Elena Damasceno, Débora Cristina [UNESP] |
dc.subject.por.fl_str_mv |
Exercise intensities Fetuses Pregnancy Swimming |
topic |
Exercise intensities Fetuses Pregnancy Swimming |
description |
This study aimed at evaluating the levels of different maternal exercise intensities on maternal and fetal outcomes. Wistar rats were mated and the pregnant rats were distributed into four experimental groups (n = 13 animals/group): Control (Not exercise group-0% of the anaerobic threshold-AT), mild (20%), moderate (80%), and heavy-exercise intensity (140% of AT). These AT were matched to the load of 0, 1, 4 and 7% of the body weight of the animal related to swimming-induced physical intensity. In pregnancy, biomarkers related to maternal blood gases, oxidative stress, metabolism, and reproductive performance, and outcomes of their offspring were analyzed. The mild and moderate-swimming caused no change on implantation, live fetus numbers and oxidative stress status. However, the rats submitted to mild-exercise presented respiratory alkalosis and the heavy-exercise group showed respiratory acidosis. In addition, fetuses of the heavy-exercise dams were smaller for gestational age and lower serum adiponectin levels compared to those of other groups. In conclusion, the moderate-exercise intensity caused beneficial effects for maternal environment and the mild and moderate-exercise presented similar fetal repercussions. Nevertheless, the heavy-exercise intensity caused maternal metabolic alterations that damaged the fetal growth. Therefore, these findings confirm that physical intensity should be carefully conducted to avoid maternal complications and, consequently, compromised fetal repercussions. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 2021-06-25T10:48:02Z 2021-06-25T10:48:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0001-3765202020191572 Anais da Academia Brasileira de Ciencias, v. 92, n. 4, p. 1-13, 2020. 1678-2690 0001-3765 http://hdl.handle.net/11449/207041 10.1590/0001-3765202020191572 S0001-37652020000700932 2-s2.0-85098492308 S0001-37652020000700932.pdf |
url |
http://dx.doi.org/10.1590/0001-3765202020191572 http://hdl.handle.net/11449/207041 |
identifier_str_mv |
Anais da Academia Brasileira de Ciencias, v. 92, n. 4, p. 1-13, 2020. 1678-2690 0001-3765 10.1590/0001-3765202020191572 S0001-37652020000700932 2-s2.0-85098492308 S0001-37652020000700932.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anais da Academia Brasileira de Ciencias |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-13 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128143286861824 |