Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates

Detalhes bibliográficos
Autor(a) principal: Santos, Juliana Alves dos
Data de Publicação: 2012
Outros Autores: Corrales, Roberta Cristina Novaes Reis, Pavan, Fernando Rogério [UNESP], Leite, Clarice Queico Fujimura [UNESP], Dias, Rafael Mafra de Paula, Silva, Adilson David da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.13171/mjc.1.6.2012.02.05.15
http://hdl.handle.net/11449/133718
Resumo: We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms.
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spelling Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydratesCarbohydrateGlycoconjugates1,2,3-triazoleAntitubercular activityWe reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms.Coordenação de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de Juiz de Fora, Departamento de Química, Instituto de Ciências ExatasUniversidade Estadual Paulista, Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas de AraraquaraFAPESP: 2008/10390-2FAPESP: 2009/06499-1Universidade Estadual Paulista (Unesp)Universidade Federal de Juiz de Fora (UFJF)Santos, Juliana Alves dosCorrales, Roberta Cristina Novaes ReisPavan, Fernando Rogério [UNESP]Leite, Clarice Queico Fujimura [UNESP]Dias, Rafael Mafra de PaulaSilva, Adilson David da2016-01-28T16:56:19Z2016-01-28T16:56:19Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article281-288application/pdfhttp://dx.doi.org/10.13171/mjc.1.6.2012.02.05.15Mediterranean Journal of Chemistry, v. 1, n. 6, p. 281-288, 2012.2028-3997http://hdl.handle.net/11449/13371810.13171/mjc.1.6.2012.02.05.15ISSN2028-3997-2012-01-06-281-288.pdf98185970769712272114570774349859Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMediterranean Journal of Chemistryinfo:eu-repo/semantics/openAccess2024-06-24T13:06:43Zoai:repositorio.unesp.br:11449/133718Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:39:40.652816Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
title Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
spellingShingle Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
Santos, Juliana Alves dos
Carbohydrate
Glycoconjugates
1,2,3-triazole
Antitubercular activity
title_short Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
title_full Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
title_fullStr Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
title_full_unstemmed Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
title_sort Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
author Santos, Juliana Alves dos
author_facet Santos, Juliana Alves dos
Corrales, Roberta Cristina Novaes Reis
Pavan, Fernando Rogério [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
Dias, Rafael Mafra de Paula
Silva, Adilson David da
author_role author
author2 Corrales, Roberta Cristina Novaes Reis
Pavan, Fernando Rogério [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
Dias, Rafael Mafra de Paula
Silva, Adilson David da
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de Juiz de Fora (UFJF)
dc.contributor.author.fl_str_mv Santos, Juliana Alves dos
Corrales, Roberta Cristina Novaes Reis
Pavan, Fernando Rogério [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
Dias, Rafael Mafra de Paula
Silva, Adilson David da
dc.subject.por.fl_str_mv Carbohydrate
Glycoconjugates
1,2,3-triazole
Antitubercular activity
topic Carbohydrate
Glycoconjugates
1,2,3-triazole
Antitubercular activity
description We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms.
publishDate 2012
dc.date.none.fl_str_mv 2012
2016-01-28T16:56:19Z
2016-01-28T16:56:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.13171/mjc.1.6.2012.02.05.15
Mediterranean Journal of Chemistry, v. 1, n. 6, p. 281-288, 2012.
2028-3997
http://hdl.handle.net/11449/133718
10.13171/mjc.1.6.2012.02.05.15
ISSN2028-3997-2012-01-06-281-288.pdf
9818597076971227
2114570774349859
url http://dx.doi.org/10.13171/mjc.1.6.2012.02.05.15
http://hdl.handle.net/11449/133718
identifier_str_mv Mediterranean Journal of Chemistry, v. 1, n. 6, p. 281-288, 2012.
2028-3997
10.13171/mjc.1.6.2012.02.05.15
ISSN2028-3997-2012-01-06-281-288.pdf
9818597076971227
2114570774349859
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mediterranean Journal of Chemistry
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 281-288
application/pdf
dc.source.none.fl_str_mv Currículo Lattes
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128259960864768