The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.tcam.2019.100389 http://hdl.handle.net/11449/199872 |
Resumo: | Intermittent hemodialysis (IHD) is a type of kidney replacement therapy commonly prescribed in veterinary medicine for cases of drug removal, fluid, acid-base, and electrolyte disorders, acute kidney injury, and cases of chronic kidney disease (CKD) in uremic crisis. This study aimed to evaluate the effects of intermittent hemodialysis in dogs with IRIS stage 4 CKD in contrast to dogs treated only with standard medical management, without dialysis, to improve their quality of life. Twenty-five dogs previously diagnosed with IRIS stage 4 CKD were selected for the study according to the inclusion criteria. Dogs were randomized to 2 distinct groups: the control group (n = 11), which underwent a conventional clinical treatment for CKD; and the hemodialysis group (n = 14), which underwent intermittent hemodialysis in addition to the clinical treatment. Both groups had a period of 15 days of clinical and laboratory evaluation. Laboratory analysis consisted of chemistry and hematological evaluation before and after both treatments at a minimum interval of 48 hours. Clinical parameters and eventual complications were assessed every 30 minutes during the IHD. When compared with conventional treatment, IHD was highly efficient in removing urea, creatinine, and phosphorus, but presented a hematological risk to the patient, requiring constant monitoring of hematological and biochemical profiles in order to correct alterations. Therefore, IHD is a highly recommended treatment if adequately monitored by trained professionals. |
id |
UNSP_5ec12b74c3cc6cfd92bcb59e129a671e |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/199872 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney DiseasedialysisdiffusionDogskidney diseasesIntermittent hemodialysis (IHD) is a type of kidney replacement therapy commonly prescribed in veterinary medicine for cases of drug removal, fluid, acid-base, and electrolyte disorders, acute kidney injury, and cases of chronic kidney disease (CKD) in uremic crisis. This study aimed to evaluate the effects of intermittent hemodialysis in dogs with IRIS stage 4 CKD in contrast to dogs treated only with standard medical management, without dialysis, to improve their quality of life. Twenty-five dogs previously diagnosed with IRIS stage 4 CKD were selected for the study according to the inclusion criteria. Dogs were randomized to 2 distinct groups: the control group (n = 11), which underwent a conventional clinical treatment for CKD; and the hemodialysis group (n = 14), which underwent intermittent hemodialysis in addition to the clinical treatment. Both groups had a period of 15 days of clinical and laboratory evaluation. Laboratory analysis consisted of chemistry and hematological evaluation before and after both treatments at a minimum interval of 48 hours. Clinical parameters and eventual complications were assessed every 30 minutes during the IHD. When compared with conventional treatment, IHD was highly efficient in removing urea, creatinine, and phosphorus, but presented a hematological risk to the patient, requiring constant monitoring of hematological and biochemical profiles in order to correct alterations. Therefore, IHD is a highly recommended treatment if adequately monitored by trained professionals.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University - UNESPDepartment of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science São Paulo State University - UNESPDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University - UNESPDepartment of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science São Paulo State University - UNESPFAPESP: 2013-02932-8Universidade Estadual Paulista (Unesp)Geraldes, Silvano Salgueiro [UNESP]Le Sueur, André Nanny Vieira [UNESP]Sant'Ana, Paula Bilbau [UNESP]de Azevedo, Maria Gabriela Picelli [UNESP]Takahira, Regina Kiomi [UNESP]Melchert, Alessandra [UNESP]Lourenço, Maria Lucia G. [UNESP]Mamprim, Maria Jaqueline [UNESP]Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]2020-12-12T01:51:34Z2020-12-12T01:51:34Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.tcam.2019.100389Topics in Companion Animal Medicine, v. 38.1938-9736http://hdl.handle.net/11449/19987210.1016/j.tcam.2019.1003892-s2.0-85077121878Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTopics in Companion Animal Medicineinfo:eu-repo/semantics/openAccess2024-09-09T14:06:26Zoai:repositorio.unesp.br:11449/199872Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:06:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease |
title |
The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease |
spellingShingle |
The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease Geraldes, Silvano Salgueiro [UNESP] dialysis diffusion Dogs kidney diseases |
title_short |
The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease |
title_full |
The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease |
title_fullStr |
The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease |
title_full_unstemmed |
The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease |
title_sort |
The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease |
author |
Geraldes, Silvano Salgueiro [UNESP] |
author_facet |
Geraldes, Silvano Salgueiro [UNESP] Le Sueur, André Nanny Vieira [UNESP] Sant'Ana, Paula Bilbau [UNESP] de Azevedo, Maria Gabriela Picelli [UNESP] Takahira, Regina Kiomi [UNESP] Melchert, Alessandra [UNESP] Lourenço, Maria Lucia G. [UNESP] Mamprim, Maria Jaqueline [UNESP] Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP] |
author_role |
author |
author2 |
Le Sueur, André Nanny Vieira [UNESP] Sant'Ana, Paula Bilbau [UNESP] de Azevedo, Maria Gabriela Picelli [UNESP] Takahira, Regina Kiomi [UNESP] Melchert, Alessandra [UNESP] Lourenço, Maria Lucia G. [UNESP] Mamprim, Maria Jaqueline [UNESP] Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Geraldes, Silvano Salgueiro [UNESP] Le Sueur, André Nanny Vieira [UNESP] Sant'Ana, Paula Bilbau [UNESP] de Azevedo, Maria Gabriela Picelli [UNESP] Takahira, Regina Kiomi [UNESP] Melchert, Alessandra [UNESP] Lourenço, Maria Lucia G. [UNESP] Mamprim, Maria Jaqueline [UNESP] Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP] |
dc.subject.por.fl_str_mv |
dialysis diffusion Dogs kidney diseases |
topic |
dialysis diffusion Dogs kidney diseases |
description |
Intermittent hemodialysis (IHD) is a type of kidney replacement therapy commonly prescribed in veterinary medicine for cases of drug removal, fluid, acid-base, and electrolyte disorders, acute kidney injury, and cases of chronic kidney disease (CKD) in uremic crisis. This study aimed to evaluate the effects of intermittent hemodialysis in dogs with IRIS stage 4 CKD in contrast to dogs treated only with standard medical management, without dialysis, to improve their quality of life. Twenty-five dogs previously diagnosed with IRIS stage 4 CKD were selected for the study according to the inclusion criteria. Dogs were randomized to 2 distinct groups: the control group (n = 11), which underwent a conventional clinical treatment for CKD; and the hemodialysis group (n = 14), which underwent intermittent hemodialysis in addition to the clinical treatment. Both groups had a period of 15 days of clinical and laboratory evaluation. Laboratory analysis consisted of chemistry and hematological evaluation before and after both treatments at a minimum interval of 48 hours. Clinical parameters and eventual complications were assessed every 30 minutes during the IHD. When compared with conventional treatment, IHD was highly efficient in removing urea, creatinine, and phosphorus, but presented a hematological risk to the patient, requiring constant monitoring of hematological and biochemical profiles in order to correct alterations. Therefore, IHD is a highly recommended treatment if adequately monitored by trained professionals. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:51:34Z 2020-12-12T01:51:34Z 2020-03-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.tcam.2019.100389 Topics in Companion Animal Medicine, v. 38. 1938-9736 http://hdl.handle.net/11449/199872 10.1016/j.tcam.2019.100389 2-s2.0-85077121878 |
url |
http://dx.doi.org/10.1016/j.tcam.2019.100389 http://hdl.handle.net/11449/199872 |
identifier_str_mv |
Topics in Companion Animal Medicine, v. 38. 1938-9736 10.1016/j.tcam.2019.100389 2-s2.0-85077121878 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Topics in Companion Animal Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1813546620866789376 |