The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease

Detalhes bibliográficos
Autor(a) principal: Geraldes, Silvano Salgueiro [UNESP]
Data de Publicação: 2020
Outros Autores: Le Sueur, André Nanny Vieira [UNESP], Sant'Ana, Paula Bilbau [UNESP], de Azevedo, Maria Gabriela Picelli [UNESP], Takahira, Regina Kiomi [UNESP], Melchert, Alessandra [UNESP], Lourenço, Maria Lucia G. [UNESP], Mamprim, Maria Jaqueline [UNESP], Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.tcam.2019.100389
http://hdl.handle.net/11449/199872
Resumo: Intermittent hemodialysis (IHD) is a type of kidney replacement therapy commonly prescribed in veterinary medicine for cases of drug removal, fluid, acid-base, and electrolyte disorders, acute kidney injury, and cases of chronic kidney disease (CKD) in uremic crisis. This study aimed to evaluate the effects of intermittent hemodialysis in dogs with IRIS stage 4 CKD in contrast to dogs treated only with standard medical management, without dialysis, to improve their quality of life. Twenty-five dogs previously diagnosed with IRIS stage 4 CKD were selected for the study according to the inclusion criteria. Dogs were randomized to 2 distinct groups: the control group (n = 11), which underwent a conventional clinical treatment for CKD; and the hemodialysis group (n = 14), which underwent intermittent hemodialysis in addition to the clinical treatment. Both groups had a period of 15 days of clinical and laboratory evaluation. Laboratory analysis consisted of chemistry and hematological evaluation before and after both treatments at a minimum interval of 48 hours. Clinical parameters and eventual complications were assessed every 30 minutes during the IHD. When compared with conventional treatment, IHD was highly efficient in removing urea, creatinine, and phosphorus, but presented a hematological risk to the patient, requiring constant monitoring of hematological and biochemical profiles in order to correct alterations. Therefore, IHD is a highly recommended treatment if adequately monitored by trained professionals.
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spelling The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney DiseasedialysisdiffusionDogskidney diseasesIntermittent hemodialysis (IHD) is a type of kidney replacement therapy commonly prescribed in veterinary medicine for cases of drug removal, fluid, acid-base, and electrolyte disorders, acute kidney injury, and cases of chronic kidney disease (CKD) in uremic crisis. This study aimed to evaluate the effects of intermittent hemodialysis in dogs with IRIS stage 4 CKD in contrast to dogs treated only with standard medical management, without dialysis, to improve their quality of life. Twenty-five dogs previously diagnosed with IRIS stage 4 CKD were selected for the study according to the inclusion criteria. Dogs were randomized to 2 distinct groups: the control group (n = 11), which underwent a conventional clinical treatment for CKD; and the hemodialysis group (n = 14), which underwent intermittent hemodialysis in addition to the clinical treatment. Both groups had a period of 15 days of clinical and laboratory evaluation. Laboratory analysis consisted of chemistry and hematological evaluation before and after both treatments at a minimum interval of 48 hours. Clinical parameters and eventual complications were assessed every 30 minutes during the IHD. When compared with conventional treatment, IHD was highly efficient in removing urea, creatinine, and phosphorus, but presented a hematological risk to the patient, requiring constant monitoring of hematological and biochemical profiles in order to correct alterations. Therefore, IHD is a highly recommended treatment if adequately monitored by trained professionals.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University - UNESPDepartment of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science São Paulo State University - UNESPDepartment of Veterinary Clinics School of Veterinary Medicine and Animal Science São Paulo State University - UNESPDepartment of Animal Reproduction and Veterinary Radiology School of Veterinary Medicine and Animal Science São Paulo State University - UNESPFAPESP: 2013-02932-8Universidade Estadual Paulista (Unesp)Geraldes, Silvano Salgueiro [UNESP]Le Sueur, André Nanny Vieira [UNESP]Sant'Ana, Paula Bilbau [UNESP]de Azevedo, Maria Gabriela Picelli [UNESP]Takahira, Regina Kiomi [UNESP]Melchert, Alessandra [UNESP]Lourenço, Maria Lucia G. [UNESP]Mamprim, Maria Jaqueline [UNESP]Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]2020-12-12T01:51:34Z2020-12-12T01:51:34Z2020-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.tcam.2019.100389Topics in Companion Animal Medicine, v. 38.1938-9736http://hdl.handle.net/11449/19987210.1016/j.tcam.2019.1003892-s2.0-85077121878Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTopics in Companion Animal Medicineinfo:eu-repo/semantics/openAccess2024-09-09T14:06:26Zoai:repositorio.unesp.br:11449/199872Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-09T14:06:26Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease
title The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease
spellingShingle The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease
Geraldes, Silvano Salgueiro [UNESP]
dialysis
diffusion
Dogs
kidney diseases
title_short The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease
title_full The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease
title_fullStr The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease
title_full_unstemmed The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease
title_sort The Effect of Intermittent Hemodialysis on the Hematological and Serum Biochemistry Profile in Dogs With Chronic Kidney Disease
author Geraldes, Silvano Salgueiro [UNESP]
author_facet Geraldes, Silvano Salgueiro [UNESP]
Le Sueur, André Nanny Vieira [UNESP]
Sant'Ana, Paula Bilbau [UNESP]
de Azevedo, Maria Gabriela Picelli [UNESP]
Takahira, Regina Kiomi [UNESP]
Melchert, Alessandra [UNESP]
Lourenço, Maria Lucia G. [UNESP]
Mamprim, Maria Jaqueline [UNESP]
Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]
author_role author
author2 Le Sueur, André Nanny Vieira [UNESP]
Sant'Ana, Paula Bilbau [UNESP]
de Azevedo, Maria Gabriela Picelli [UNESP]
Takahira, Regina Kiomi [UNESP]
Melchert, Alessandra [UNESP]
Lourenço, Maria Lucia G. [UNESP]
Mamprim, Maria Jaqueline [UNESP]
Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Geraldes, Silvano Salgueiro [UNESP]
Le Sueur, André Nanny Vieira [UNESP]
Sant'Ana, Paula Bilbau [UNESP]
de Azevedo, Maria Gabriela Picelli [UNESP]
Takahira, Regina Kiomi [UNESP]
Melchert, Alessandra [UNESP]
Lourenço, Maria Lucia G. [UNESP]
Mamprim, Maria Jaqueline [UNESP]
Guimarães-Okamoto, Priscylla Tatiana Chalfun [UNESP]
dc.subject.por.fl_str_mv dialysis
diffusion
Dogs
kidney diseases
topic dialysis
diffusion
Dogs
kidney diseases
description Intermittent hemodialysis (IHD) is a type of kidney replacement therapy commonly prescribed in veterinary medicine for cases of drug removal, fluid, acid-base, and electrolyte disorders, acute kidney injury, and cases of chronic kidney disease (CKD) in uremic crisis. This study aimed to evaluate the effects of intermittent hemodialysis in dogs with IRIS stage 4 CKD in contrast to dogs treated only with standard medical management, without dialysis, to improve their quality of life. Twenty-five dogs previously diagnosed with IRIS stage 4 CKD were selected for the study according to the inclusion criteria. Dogs were randomized to 2 distinct groups: the control group (n = 11), which underwent a conventional clinical treatment for CKD; and the hemodialysis group (n = 14), which underwent intermittent hemodialysis in addition to the clinical treatment. Both groups had a period of 15 days of clinical and laboratory evaluation. Laboratory analysis consisted of chemistry and hematological evaluation before and after both treatments at a minimum interval of 48 hours. Clinical parameters and eventual complications were assessed every 30 minutes during the IHD. When compared with conventional treatment, IHD was highly efficient in removing urea, creatinine, and phosphorus, but presented a hematological risk to the patient, requiring constant monitoring of hematological and biochemical profiles in order to correct alterations. Therefore, IHD is a highly recommended treatment if adequately monitored by trained professionals.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T01:51:34Z
2020-12-12T01:51:34Z
2020-03-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.tcam.2019.100389
Topics in Companion Animal Medicine, v. 38.
1938-9736
http://hdl.handle.net/11449/199872
10.1016/j.tcam.2019.100389
2-s2.0-85077121878
url http://dx.doi.org/10.1016/j.tcam.2019.100389
http://hdl.handle.net/11449/199872
identifier_str_mv Topics in Companion Animal Medicine, v. 38.
1938-9736
10.1016/j.tcam.2019.100389
2-s2.0-85077121878
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Topics in Companion Animal Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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